Tumor microenvironment and cellular senescence: Understanding therapeutic resistance and harnessing strategies

Doxorubicin‐induced senescence promotes stemness and tumorigenicity in EpCAM−/CD133− nonstem cell population in hepatocellular carcinoma cell line, HuH‐7

(2021) Mustafa Karabicici et al.   Molecular Oncology

Lymphatic Endothelial Cell Activation and Dendritic Cell Transmigration Is Modified by Genetic Deletion of Clever-1

(2021) Sina Tadayon et al.   Frontiers in Immunology

Biology and Clinical Applicability of Plasma Thymus and Activation-Regulated Chemokine (TARC) in Classical Hodgkin Lymphoma

(2021) Eline A. M. Zijtregtop et al.   Cancers

Cancer Response to Therapy-Induced Senescence: A Matter of Dose and Timing

(2021) Maria Patrizia Mongiardi et al.   Cancers

Hypoxia-Induced Reactivity of Tumor-Associated Astrocytes Affects Glioma Cell Properties

(2021) Vasiliki Pantazopoulou et al.   Cells

Association between obesity and neurocognitive function in survivors of childhood acute lymphoblastic leukemia treated only with chemotherapy

(2021) Mayuko Iijima et al.   CANCER

Normoxic induction of HIF‐1α by adenosine‐A 2B R signaling in epicardial stromal cells formed after myocardial infarction

(2021) Julia Hesse et al.   FASEB JOURNAL

The inflammatory speech of fibroblasts

(2021) Ronen Schuster et al.   IMMUNOLOGICAL REVIEWS

Algorithmic assessment of cellular senescence in experimental and clinical specimens

(2021) J. Kohli et al.   Nature Protocols

Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma

(2021) Naofumi Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological functions of therapy-induced senescence in cancer

(2021) Eleni Fitsiou et al.   SEMINARS IN CANCER BIOLOGY

Immunomodulation of T Helper Cells by Tumor Microenvironment in Oral Cancer Is Associated With CCR8 Expression and Rapid Membrane Vitamin D Signaling Pathway

(2021) Marco Fraga et al.   Frontiers in Immunology

Nutritional Status at Diagnosis, During, and After Treatment in Adolescents and Young Adults with Cancer

(2021) Natalie van der Haak et al.   Journal of Adolescent and Young Adult Oncology

Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells

(2021) Jonathan Tucci et al.   Frontiers in Oncology

Overexpression of TGF-β1 and SDF-1 in cervical cancer-associated fibroblasts promotes cell growth, invasion and migration

(2021) Ling Xiao et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

(2021) Marcus Ruscetti et al.   CELL

Novel nanomedicines to overcome cancer multidrug resistance

(2021) Zhenwei Su et al.   DRUG RESISTANCE UPDATES

VEGF Regulation of Angiogenic Factors via Inflammatory Signaling in Myeloproliferative Neoplasms

(2021) Tijana Subotički et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

(2021) Alba Nicolas-Boluda et al.   eLife

Natural Killer Cell Dysfunction in Obese Patients with Breast Cancer: A Review of a Triad and Its Implications

(2021) Esraa Elaraby et al.   Journal of Immunology Research

Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance

(2021) Khalil Khalaf et al.   Frontiers in Immunology

Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway

(2021) Chengjun Hu et al.   Redox Biology

Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses

(2021) Amit Jairaman et al.   Science Advances

IL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC)

(2021) Russell K Pachynski et al.   Journal for ImmunoTherapy of Cancer

Recent Advances in Experimental Dendritic Cell Vaccines for Cancer

(2021) Ivan Y. Filin et al.   Frontiers in Oncology

Canine Transforming Growth Factor-β Receptor 2-Ig: A Potential Candidate Biologic for Melanoma Treatment That Reverses Transforming Growth Factor-β1 Immunosuppression

(2021) Hiroto Takeuchi et al.   Frontiers in Veterinary Science

NLRP3-activated bone marrow dendritic cells play antileukemic roles via IL-1β/Th1/IFN-γ in acute myeloid leukemia

(2021) Qinqin Liu et al.   CANCER LETTERS

Senescent cells in cancer therapy: why and how to remove them

(2021) Jian-Wei Zhang et al.   CANCER LETTERS

Apatinib inhibits the growth of small cell lung cancer via a mechanism mediated by VEGF, PI3K/Akt and Ki‐67/CD31

(2021) Ning Zhong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice

(2020) Chi Zhang et al.   Aging-US

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

(2020) Jermaine Goveia et al.   CANCER CELL

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles

(2020) Liu Han et al.   CANCER RESEARCH

BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer

(2020) Ashkan Shahbandi et al.   CELL DEATH AND DIFFERENTIATION

JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells

(2020) Wenjing Wu et al.   JOURNAL OF ENDOCRINOLOGY

The role of cellular senescence in ageing and endocrine disease

(2020) Sundeep Khosla et al.   Nature Reviews Endocrinology

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

(2020) Shuling Song et al.   TRENDS IN BIOCHEMICAL SCIENCES

The role of tumor-stroma interactions on desmoplasia and tumorigenicity within a microengineered 3D platform

(2020) Harpinder Saini et al.   BIOMATERIALS

New tools to prevent cancer growth and spread: a ‘Clever’ approach

(2020) Maija Hollmén et al.   BRITISH JOURNAL OF CANCER

Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor–A Literature Review

(2020) Jan Korbecki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Fibroblast growth factor‐2, derived from cancer‐associated fibroblasts, stimulates growth and progression of human breast cancer cells via FGFR1 signaling

(2020) Jinyoung Suh et al.   MOLECULAR CARCINOGENESIS

Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐X L –BAX interaction

(2020) Tareq Saleh et al.   Molecular Oncology

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following L-Asparaginase Chemotherapy

(2020) Colin R. Young et al.   CLINICAL NUCLEAR MEDICINE

Gemcitabine potentiates anti-tumor effect of resveratrol on pancreatic cancer via down-regulation of VEGF-B

(2020) Yinan Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

IL‐8/CXCR2 mediates tropism of human bone marrow‐derived mesenchymal stem cells toward CD133 + /CD44 + Colon cancer stem cells

(2020) Xiaoying Ma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives

(2020) Laurenz Nagl et al.   Frontiers in Cell and Developmental Biology

Senescence: A program in the road to cell elimination and cancer

(2020) Olga Moiseeva et al.   SEMINARS IN CANCER BIOLOGY

Partial acquisition of stemness properties in tumorspheres obtained from interleukin-8-treated MCF-7 cells

(2020) Natalia Ospina-Muñoz et al.   TUMOR BIOLOGY

Tumor-Associated Macrophages in Tumor Immunity

(2020) Yueyun Pan et al.   Frontiers in Immunology

The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence

(2020) Chenxi Liao et al.   Cancer Management and Research

Carcinoma-Associated Fibroblasts Promote Growth of Sox2-Expressing Breast Cancer Cells

(2020) Angela Dittmer et al.   Cancers

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

(2020) Muyue Yang et al.   Bioactive Materials

Using the drug-protein interactome to identify anti-ageing compounds for humans

(2019) Matías Fuentealba et al.   PLoS Computational Biology

Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade

(2019) Christopher D. Cluxton et al.   PLoS One

Targeting Tumor Microenvironment for Cancer Therapy

(2019) Catarina Roma-Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

(2019) Tareq Saleh et al.   CANCER RESEARCH

Neutrophil plasticity in the tumor microenvironment

(2019) Morgan Giese et al.   BLOOD

The curcumin analog EF24 is a novel senolytic agent

(2019) Wen Li et al.   Aging-US

Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression

(2019) Xiaojie Bian et al.   Molecular Cancer

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

(2019) Georges E. Janssens et al.   Cell Reports

Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

(2019) Hosni Cherif et al.   Journal of Clinical Medicine

In chronic hypoxia, glucose availability and hypoxic severity dictate the balance between HIF-1 and HIF-2 in astrocytes

(2019) Min Guo et al.   FASEB JOURNAL

Adipocyte and lipid metabolism in cancer drug resistance

(2019) Yihai Cao   JOURNAL OF CLINICAL INVESTIGATION

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance

(2019) Maria Laura De Angelis et al.   Frontiers in Oncology

Obesity and Breast Cancer: Role of Leptin

(2019) Flora Sánchez-Jiménez et al.   Frontiers in Oncology

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression

(2019) Qixia Xu et al.   AGING CELL

Connecting cancer relapse with senescence

(2019) Olivier Pluquet et al.   CANCER LETTERS

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Inducing and exploiting vulnerabilities for the treatment of liver cancer

(2019) Cun Wang et al.   NATURE

A centralized communication network: Recent insights into the role of the cancer associated fibroblast in the development of drug resistance in tumors

(2019) Andrew Leask   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

NK Cell Metabolism and TGFβ – Implications for Immunotherapy

(2019) Karen Slattery et al.   Frontiers in Immunology

Oxidation resistance 1 is a novel senolytic target

(2018) Xin Zhang et al.   AGING CELL

Oxidative modifications of extracellular matrix promote the second wave of inflammation via β2integrins

(2018) Valentin P. Yakubenko et al.   BLOOD

Targeting the microenvironment in solid tumors

(2018) Carmen Belli et al.   CANCER TREATMENT REVIEWS

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri

(2018) Shan Liu et al.   FISH & SHELLFISH IMMUNOLOGY

The senescent bystander effect is caused by ROS-activated NF-κB signalling

(2018) Glyn Nelson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy

(2018) Marco Malavolta et al.   MEDIATORS OF INFLAMMATION

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

(2018) Kevin C. Barry et al.   NATURE MEDICINE

The dark side of tumor-associated endothelial cells

(2018) Francesco De Sanctis et al.   SEMINARS IN IMMUNOLOGY

Two-Step Senescence-Focused Cancer Therapies

(2018) Cynthia J. Sieben et al.   TRENDS IN CELL BIOLOGY

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

(2018) Boyi Zhang et al.   Nature Communications

Leptin-Notch axis impairs 5-fluorouracil effects on pancreatic cancer

(2018) Adriana Harbuzariu et al.   Oncotarget

The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle

(2018) Maja Milanovic et al.   TRENDS IN CELL BIOLOGY

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma

(2018) Livingstone Fultang et al.   CANCER RESEARCH

State-of-the-art strategies for targeting the DNA damage response in cancer

(2018) Patrick G. Pilié et al.   Nature Reviews Clinical Oncology

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Metastatic growth instructed by neutrophil-derived transferrin

(2018) Wei Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance

(2018) Fei Chen et al.   Nature Communications

Resistin induces multidrug resistance in myeloma by inhibiting cell death and upregulating ABC transporter expression

(2017) Jianan Pang et al.   HAEMATOLOGICA

Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j

(2017) Sol Y. Nuñez et al.   JOURNAL OF IMMUNOLOGY

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours

(2017) Hyungseok Seo et al.   Nature Communications

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

(2017) Liqin Wang et al.   Cell Reports

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

(2017) Paul J Brighton et al.   eLife

Resistin induces multidrug resistance in myeloma by inhibiting cell death and upregulating ABC transporter expression

(2017) Jianan Pang et al.   HAEMATOLOGICA

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC

(2017) Leleesha Samaraweera et al.   Scientific Reports

Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence

(2016) Nicole Noren Hooten et al.   AGING CELL

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

(2016) Yingying Wang et al.   Aging-US

Obesity, Inflammation, and Cancer

(2016) Tuo Deng et al.   Annual Review of Pathology-Mechanisms of Disease

Tumor microenvironment and cancer therapy resistance

(2016) Yu Sun   CANCER LETTERS

Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype

(2016) Nicolas Malaquin et al.   EXPERIMENTAL GERONTOLOGY

SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment

(2016) Y Sun et al.   ONCOGENE

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

(2016) Damya Laoui et al.   Nature Communications

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response

(2016) Xia Sheng et al.   Oncotarget

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages

(2016) Hideyuki Takahashi et al.   Oncotarget

Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling

(2016) Eunice Yuen Ting Lau et al.   Cell Reports

The Essential Role of Type I Interferons in Differentiation and Activation of Tumor-Associated Neutrophils

(2016) Ekaterina Pylaeva et al.   Frontiers in Immunology

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

(2016) Sona Hubackova et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts

(2015) Hyun Lim et al.   BIOCHEMICAL PHARMACOLOGY

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1

(2015) Barbara Jonchère et al.   Oncotarget

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Ovarian Cancer Biology and Immunotherapy

(2014) T. Sree Latha et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Cytotoxic T Lymphocytes Block Tumor Growth Both by Lytic Activity and IFN -Dependent Cell-Cycle Arrest

(2014) H. Matsushita et al.   Cancer Immunology Research

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells

(2013) Seog-Young Kim et al.   CELLULAR SIGNALLING

Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1

(2013) Justyna Mikuła-Pietrasik et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression

(2013) G Comito et al.   ONCOGENE

Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation

(2013) Mirjam Stahl et al.   PLoS One

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF and Notch in Tip and Stalk Cell Selection

(2013) R. Blanco et al.   Cold Spring Harbor Perspectives in Medicine

Glucocorticoids suppress selected components of the senescence-associated secretory phenotype

(2012) Remi-Martin Laberge et al.   AGING CELL

CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells

(2012) A. Tsuyada et al.   CANCER RESEARCH

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

(2012) Swarnali Acharyya et al.   CELL

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Chronic Resveratrol Treatment Ameliorates Cell Adhesion and Mitigates the Inflammatory Phenotype in Senescent Human Fibroblasts

(2012) V. Pitozzi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma

(2012) Nadia Lago Costa et al.   ORAL ONCOLOGY

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth

(2012) Taku Fujimura et al.   OncoImmunology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors

(2011) Francesco Dituri et al.   Clinical & Developmental Immunology

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

VEGF directly suppresses activation of T cells from ovarian cancer patients and healthy individuals via VEGF receptor Type 2

(2011) Apostolos C. Ziogas et al.   INTERNATIONAL JOURNAL OF CANCER

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Antiangiogenic therapy: impact on invasion, disease progression and metastasis

(2011) John M. L. Ebos et al.   Nature Reviews Clinical Oncology

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Induction of senescence markers after neo-adjuvant chemotherapy of malignant pleural mesothelioma and association with clinical outcome: An exploratory analysis

(2010) Roy Sidi et al.   EUROPEAN JOURNAL OF CANCER

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

(2010) Andrea Alimonti et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways

(2010) X Rao et al.   ONCOGENE

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Transcriptional Switch of Dormant Tumors to Fast-Growing Angiogenic Phenotype

(2009) N. Almog et al.   CANCER RESEARCH

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

(2007) Ronald J Buckanovich et al.   NATURE MEDICINE