Using the drug-protein interactome to identify anti-ageing compounds for humans

Gene Expression-Based Drug Repurposing to Target Ageing

(2018) Handan Melike Dönertaş et al.   AGING CELL

Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers

(2018) Terry W. Snell et al.   BIOGERONTOLOGY

Beneficial and paradoxical roles of selenium at nutritional levels of intake in healthspan and longevity

(2018) Li Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

DAF-21/Hsp90 is required for C. elegans longevity by ensuring DAF-16/FOXO isoform A function

(2018) Milán Somogyvári et al.   Scientific Reports

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state

(2016) Alexander Aliper et al.   Aging-US

DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing

(2016) Naiem T. Issa et al.   BMC BIOINFORMATICS

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

After surviving cancer, what about late life effects of the cure?

(2016) Julie Nonnekens et al.   EMBO Molecular Medicine

Association between longevity and element levels in food and drinking water of typical Chinese longevity area

(2016) Z. Hao et al.   Journal of Nutrition Health & Aging

Strategies and Challenges in Clinical Trials Targeting Human Aging

(2016) John C. Newman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization

(2016) Guangchuang Yu et al.   Molecular BioSystems

Gerontology: Extending the healthspan

(2016) Linda Partridge   NATURE

CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases

(2016) M Zhao et al.   Cell Death & Disease

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

A network pharmacology approach reveals new candidate caloric restriction mimetics inC. elegans

(2015) Shaun Calvert et al.   AGING CELL

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

(2015) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Single Cell Quantification of Reporter Gene Expression in Live Adult Caenorhabditis elegans Reveals Reproducible Cell-Specific Expression Patterns and Underlying Biological Variation

(2015) Alexander R. Mendenhall et al.   PLoS One

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs

(2014) Alex Zhavoronkov et al.   Frontiers in Genetics

The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine

(2013) Peter D. Stenson et al.   HUMAN GENETICS

DGIdb: mining the druggable genome

(2013) Malachi Griffith et al.   NATURE METHODS

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data

(2013) Sebastian Köhler et al.   NUCLEIC ACIDS RESEARCH

LongevityMap: a database of human genetic variants associated with longevity

(2013) Arie Budovsky et al.   TRENDS IN GENETICS

UniChem: a unified chemical structure cross-referencing and identifier tracking system

(2013) Jon Chambers et al.   Journal of Cheminformatics

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span

(2012) S. L. Andersen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing

(2012) Robi Tacutu et al.   NUCLEIC ACIDS RESEARCH

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity

(2011) Tsui-Ting Ching et al.   AGING CELL

The aging effect of chemotherapy on cultured human mesenchymal stem cells

(2011) Stefano Buttiglieri et al.   EXPERIMENTAL HEMATOLOGY

bioDBnet: the biological database network

(2009) Uma Mudunuri et al.   BIOINFORMATICS

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

Heat Shock Transcription Factor 1-activating Compounds Suppress Polyglutamine-induced Neurodegeneration through Induction of Multiple Molecular Chaperones

(2008) Nobuhiro Fujikake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY