Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence

Circulatory miR-34a as an RNA-based, noninvasive biomarker for brain aging

(2016) Xiaoli Li et al.   Aging-US

Age-associated miRNA Alterations in Skeletal Muscle from Rhesus Monkeys reversed by caloric restriction

(2016) Evi M. Mercken et al.   Aging-US

Age-related changes in microRNA levels in serum

(2016) Nicole Noren Hooten et al.   Aging-US

Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction

(2015) Bethany E. Schaffer et al.   Cell Metabolism

Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats

(2015) Frank A Duca et al.   NATURE MEDICINE

Swiss army knives: non-canonical functions of nuclear Drosha and Dicer

(2015) Kaspar Burger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Noncoding RNA control of cellular senescence

(2015) Kotb Abdelmohsen et al.   Wiley Interdisciplinary Reviews-RNA

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

(2014) C. A. Bannister et al.   DIABETES OBESITY & METABOLISM

Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents

(2014) Minh Truong Do et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

(2014) Jing Y. Krzeszinski et al.   NATURE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Reduction of AUF1-mediated follistatin mRNA decay during glucose starvation protects cells from apoptosis

(2014) Xiangwei Gao et al.   NUCLEIC ACIDS RESEARCH

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity

(2014) Je-Hyun Yoon et al.   Nature Communications

Hsp27 and F-Box Protein  -TrCP Promote Degradation of mRNA Decay Factor AUF1

(2013) M.-L. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Post-transcriptional control of gene expression by AUF1: Mechanisms, physiological targets, and regulation

(2012) Elizabeth J.F. White et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Metformin lowers the threshold for stress-induced senescence: A role for the microRNA-200 family and miR-205

(2012) Sílvia Cufí et al.   CELL CYCLE

Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity

(2012) Marcelo A. Mori et al.   Cell Metabolism

MicroRNAs and their roles in aging

(2012) T. Smith-Vikos et al.   JOURNAL OF CELL SCIENCE

Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells

(2012) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription

(2012) Adam R. Pont et al.   MOLECULAR CELL

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

(2012) Nan Liu et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA-binding protein AUF1 represses Dicer expression

(2012) Kotb Abdelmohsen et al.   NUCLEIC ACIDS RESEARCH

Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC

(2012) Giovanni Blandino et al.   Nature Communications

Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

(2012) Michael N. Pollak   Cancer Discovery

miRNA Processing and Human Cancer: DICER1 Cuts the Mustard

(2011) A. Bahubeshi et al.   Science Translational Medicine

microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age

(2010) Nicole Noren Hooten et al.   PLoS One

The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells

(2009) M Kato et al.   ONCOGENE

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells

(2008) Rajini Mudhasani et al.   JOURNAL OF CELL BIOLOGY

Sequence Relationships among C. elegans, D. melanogaster and Human microRNAs Highlight the Extensive Conservation of microRNAs in Biology

(2008) Carolina Ibáñez-Ventoso et al.   PLoS One

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY