PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors

Selective Regulation of CD8 Effector T Cell Migration by the p110  Isoform of Phosphatidylinositol 3-Kinase

(2014) A. L. Martin et al.   JOURNAL OF IMMUNOLOGY

The role of phosphatidylinositol 3-kinase-  in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia

(2011) S. E. M. Herman et al.   BLOOD

A class IA PI3K controls inflammatory cytokine production in human neutrophils

(2011) Carl F. Fortin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab

(2011) Dirk Nagorsen et al.   EXPERIMENTAL CELL RESEARCH

PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma

(2011) Francesco Dituri et al.   INTERNATIONAL JOURNAL OF CANCER

MHC Class II Engagement by Its Ligand LAG-3 (CD223) Contributes to Melanoma Resistance to Apoptosis

(2011) P. Hemon et al.   JOURNAL OF IMMUNOLOGY

Inositol Phospholipid Signaling and the Biology of Natural Killer Cells

(2011) William G. Kerr et al.   Journal of Innate Immunity

A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110  Isoform in Medulloblastoma Cell Proliferation and Chemoresistance

(2011) A. S. Guerreiro et al.   MOLECULAR CANCER RESEARCH

E7080 Suppresses Hematogenous Multiple Organ Metastases of Lung Cancer Cells with Nonmutated Epidermal Growth Factor Receptor

(2011) H. Ogino et al.   MOLECULAR CANCER THERAPEUTICS

Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

(2011) A. C. Benitez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A preferential p110α/γ PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-κB-dependent manner

(2010) Nilesh M. Dagia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Recent advances on the immunomodulatory effects of IFN-α: Implications for cancer immunotherapy and autoimmunity

(2010) Paola Rizza et al.   AUTOIMMUNITY

CAL-101, a p110  selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

(2010) B. J. Lannutti et al.   BLOOD

Phosphatidylinositol 3-kinase-  inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

(2010) S. E. M. Herman et al.   BLOOD

Induction of Monocyte Chemoattractant Protein-1 and Interleukin-10 by TGF 1 in Melanoma Enhances Tumor Infiltration and Immunosuppression

(2010) N. Diaz-Valdes et al.   CANCER RESEARCH

PI3K signalling in lymphocyte migration

(2010) Aurore Saudemont et al.   CELL CYCLE

Key Role of Phosphoinositide 3-Kinase Class IB in Pancreatic Cancer

(2010) C. E. Edling et al.   CLINICAL CANCER RESEARCH

Interleukin 10 decreases MICA expression on melanoma cell surface

(2010) Antonio E Serrano et al.   IMMUNOLOGY AND CELL BIOLOGY

The BCR/ABL-inhibitors imatinib, nilotinib and dasatinib differentially affect NK cell reactivity

(2010) Julia Salih et al.   INTERNATIONAL JOURNAL OF CANCER

IFN-  Inhibits IL-4-Induced Type 2 Cytokine Expression by CD8 T Cells In Vivo and Modulates the Anti-Tumor Response

(2010) S. H. Apte et al.   JOURNAL OF IMMUNOLOGY

Slit2 Regulates Attractive Eosinophil and Repulsive Neutrophil Chemotaxis through Differential srGAP1 Expression during Lung Inflammation

(2010) B.-Q. Ye et al.   JOURNAL OF IMMUNOLOGY

A Versatile Role of Mammalian Target of Rapamycin in Human Dendritic Cell Function and Differentiation

(2010) M. Haidinger et al.   JOURNAL OF IMMUNOLOGY

Absence of PI3Kγ leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis

(2010) David Henrique Rodrigues et al.   JOURNAL OF NEUROIMMUNOLOGY

Thalidomide in lung cancer therapy—what have we learned?

(2010) Martin Reck et al.   Nature Reviews Clinical Oncology

Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)

(2010) Marta Szajnik et al.   PLoS One

A biochemical mechanism for the oncogenic potential of the p110  catalytic subunit of phosphoinositide 3-kinase

(2010) H. A. Dbouk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-derived mutations in the regulatory subunit p85  of phosphoinositide 3-kinase function through the catalytic subunit p110 

(2010) M. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A constitutively activated form of the p110  isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice

(2010) S. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SA-4-1BBL as the immunomodulatory component of a HPV-16 E7 protein based vaccine shows robust therapeutic efficacy in a mouse cervical cancer model

(2010) Rajesh K. Sharma et al.   VACCINE

Immunomodulatory Agents with Antivascular Activity in the Treatment of Non-Small Cell Lung Cancer: Focus on TLR9 Agonists, IMiDs and NGR-TNF

(2010) Angelo Corti et al.   Journal of Oncology

Involvement of matrix metalloproteinase-3 in CCL5/CCR5 pathway of chondrosarcomas metastasis

(2009) Chih-Hsin Tang et al.   BIOCHEMICAL PHARMACOLOGY

Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway

(2009) Olga V Efimova et al.   BMC IMMUNOLOGY

IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death

(2009) M Czystowska et al.   CELL DEATH AND DIFFERENTIATION

Phosphatidylinositol 3-Kinase γ Inhibition Ameliorates Inflammation and Tumor Growth in a Model of Colitis-Associated Cancer

(2009) Ana González–García et al.   GASTROENTEROLOGY

Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9

(2009) Keisuke Kohga et al.   HEPATOLOGY

PI3K Links NKG2D Signaling to a CrkL Pathway Involved in Natural Killer Cell Adhesion, Polarity, and Granule Secretion

(2009) C. M. Segovis et al.   JOURNAL OF IMMUNOLOGY

The Kinase Inhibitors Sunitinib and Sorafenib Differentially Affect NK Cell Antitumor Reactivity In Vitro

(2009) M. Krusch et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Vascular Endothelial Growth Factor-Mediated Signaling in Human CD45RO+ CD4+ T Cells Promotes Akt and ERK Activation and Costimulates IFN-  Production

(2009) A. Basu et al.   JOURNAL OF IMMUNOLOGY

PI3K p110  Positively Regulates Lipopolysaccharide-Induced IL-12 Production in Human Macrophages and Dendritic Cells and JNK1 Plays a Novel Role

(2009) M. Utsugi et al.   JOURNAL OF IMMUNOLOGY

Honokiol-mediated Inhibition of PI3K/mTOR Pathway

(2009) Courtney Crane et al.   JOURNAL OF IMMUNOTHERAPY

p110  and p110  isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease

(2009) A. Saudemont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemic challenge unmasks a requirement for PI3K  in NK cell-mediated tumor surveillance

(2008) E. Zebedin et al.   BLOOD

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

(2008) M. Ohtani et al.   BLOOD

TSU68 Prevents Liver Metastasis of Colon Cancer Xenografts by Modulating the Premetastatic Niche

(2008) M. Yamamoto et al.   CANCER RESEARCH

Natural Killer Cell Accumulation in Tumors Is Dependent on IFN-  and CXCR3 Ligands

(2008) M. Wendel et al.   CANCER RESEARCH

Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-γ Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes

(2008) Anne Fougerat et al.   CIRCULATION

Targeting the Phosphoinositide 3-Kinase Isoform p110  Impairs Growth and Survival in Neuroblastoma Cells

(2008) D. Boller et al.   CLINICAL CANCER RESEARCH

Deletion of PI3K-p85α gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells

(2008) A Awasthi et al.   GENES AND IMMUNITY

Anti–Cytotoxic T-Lymphocyte Antigen-4 Antibody: The First in an Emerging Class of Immunomodulatory Antibodies for Cancer Treatment

(2008) Lawrence Fong et al.   JOURNAL OF CLINICAL ONCOLOGY

The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation

(2008) Hailong Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The p110γ isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites

(2008) Molly S. Thomas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immune manipulation of advanced breast cancer: An interpretative model of the relationship between immune system and tumor cell biology

(2008) Andrea Nicolini et al.   MEDICINAL RESEARCH REVIEWS

Activation of Akt as a Mechanism for Tumor Immune Evasion

(2008) Kyung Hee Noh et al.   MOLECULAR THERAPY

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

(2008) Shidong Jia et al.   NATURE

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

Cancer Immunology

(2008) Olivera J. Finn   NEW ENGLAND JOURNAL OF MEDICINE

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA