Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Pericytes and vessel maturation during tumor angiogenesis and metastasis

(2010) Ahmad Raza et al.   AMERICAN JOURNAL OF HEMATOLOGY

Contrast enhanced MRI and intravital fluorescence microscopy indicate improved tumor microcirculation in highly vascularized melanomas upon short-term anti-VEGFR treatment

(2010) M.E. Eichhorn et al.   CANCER BIOLOGY & THERAPY

Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

(2010) Young Jun Koh et al.   CANCER CELL

Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer

(2010) R. K. Shrimali et al.   CANCER RESEARCH

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

(2010) S. Rey et al.   CARDIOVASCULAR RESEARCH

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth

(2010) Carlos Bais et al.   CELL

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

(2010) Sara Van de Veire et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Angiopoietin-2 Interferes with Anti-VEGFR2-Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas

(2010) S.-S. Chae et al.   CLINICAL CANCER RESEARCH

Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse

(2010) Feng-Ju Huang et al.   DEVELOPMENTAL BIOLOGY

Improved Intratumoral Oxygenation Through Vascular Normalization Increases Glioma Sensitivity to Ionizing Radiation

(2010) Mackenzie C. McGee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma

(2010) Tracy T. Batchelor et al.   JOURNAL OF CLINICAL ONCOLOGY

Disease Course Patterns After Discontinuation of Bevacizumab: Pooled Analysis of Randomized Phase III Trials

(2010) David Miles et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor vessel biology in pediatric intracranial ependymoma

(2010) Michiel Wagemakers et al.   Journal of Neurosurgery-Pediatrics

Bevacizumab-induced tumor vessel remodeling in rhabdomyosarcoma xenografts increases the effectiveness of adjuvant ionizing radiation

(2010) Adrianne L. Myers et al.   JOURNAL OF PEDIATRIC SURGERY

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

Effect of Pazopanib on Tumor Microenvironment and Liposome Delivery

(2010) T. D. Tailor et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks

(2010) Walid S Kamoun et al.   NATURE METHODS

In vivo wide-area cellular imaging by side-view endomicroscopy

(2010) Pilhan Kim et al.   NATURE METHODS

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Plasma Soluble VEGFR-1 Is a Potential Dual Biomarker of Response and Toxicity for Bevacizumab with Chemoradiation in Locally Advanced Rectal Cancer

(2010) D. G. Duda et al.   ONCOLOGIST

Heterogeneity of the Tumor Vasculature

(2010) Janice Nagy et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

(2009) Beverly L. Falcón et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular differentiation and specialization of vascular beds

(2009) Susana F. Rocha et al.   ANGIOGENESIS

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth

(2009) Patrick Nasarre et al.   CANCER RESEARCH

A “Vascular Normalization Index” as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients

(2009) A. Gregory Sorensen et al.   CANCER RESEARCH

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism

Human Studies of Angiogenic Gene Therapy

(2009) Rajesh Gupta et al.   CIRCULATION RESEARCH

Quantifying Antivascular Effects of Monoclonal Antibodies to Vascular Endothelial Growth Factor: Insights from Imaging

(2009) J. P.B. O'Connor et al.   CLINICAL CANCER RESEARCH

The Extracellular Matrix of Blood Vessels

(2009) Johannes Eble et al.   CURRENT PHARMACEUTICAL DESIGN

Pathways mediating VEGF-independent tumor angiogenesis

(2009) Napoleone Ferrara   CYTOKINE & GROWTH FACTOR REVIEWS

Role of Placental Growth Factor in Mesenteric Neoangiogenesis in a Mouse Model of Portal Hypertension

(2009) Christophe Van Steenkiste et al.   GASTROENTEROLOGY

Efficacy, Safety, and Potential Biomarkers of Sunitinib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study

(2009) Andrew X. Zhu et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study

(2009) Christopher G. Willett et al.   JOURNAL OF CLINICAL ONCOLOGY

Edema Control by Cediranib, a Vascular Endothelial Growth Factor Receptor–Targeted Kinase Inhibitor, Prolongs Survival Despite Persistent Brain Tumor Growth in Mice

(2009) Walid S. Kamoun et al.   JOURNAL OF CLINICAL ONCOLOGY

Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells

(2009) Katrien De Bock et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hearing Improvement after Bevacizumab in Patients with Neurofibromatosis Type 2

(2009) Scott R. Plotkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature

(2009) E.-M. Hedlund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress

(2009) Mark W. Dewhirst   RADIATION RESEARCH

Vascular Changes in Hepatocellular Carcinoma

(2008) Zhen Fan Yang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

The role of endothelial-to-mesenchymal transition in cancer progression

(2008) S Potenta et al.   BRITISH JOURNAL OF CANCER

VEGF inhibition: insights from preclinical and clinical studies

(2008) Yongping Crawford et al.   CELL AND TISSUE RESEARCH

Microvascular endothelial cell heterogeneity: general concepts and pharmacological consequences for anti-angiogenic therapy of cancer

(2008) Elise Langenkamp et al.   CELL AND TISSUE RESEARCH

The tumor microenvironment and metastatic disease

(2008) Sarah Jane Lunt et al.   CLINICAL & EXPERIMENTAL METASTASIS

Impact of Angiogenesis Inhibition by Sunitinib on Tumor Distribution of Temozolomide

(2008) Q. Zhou et al.   CLINICAL CANCER RESEARCH

Generation and Characterization of rgs5 Mutant Mice

(2008) M. H. Nisancioglu et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib

(2008) T. P. Padera et al.   MOLECULAR CANCER THERAPEUTICS

Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization

(2008) A. Claes et al.   MOLECULAR CANCER THERAPEUTICS

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

(2008) Juliana Hamzah et al.   NATURE

A role for VEGF as a negative regulator of pericyte function and vessel maturation

(2008) Joshua I. Greenberg et al.   NATURE

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

(2008) Christian Stockmann et al.   NATURE

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY

Perivascular nitric oxide gradients normalize tumor vasculature

(2008) Satoshi Kashiwagi et al.   NATURE MEDICINE

Response criteria for glioma

(2008) A Gregory Sorensen et al.   Nature clinical practice. Oncology