Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

(2018) Maria Mantzorou et al.   PHYTOTHERAPY RESEARCH

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Cellular senescence in osteoarthritis and anti-aging strategies

(2018) Angyang Hou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cellular Senescence: The Sought or the Unwanted?

(2018) Yu Sun et al.   TRENDS IN MOLECULAR MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

The Fountain of Youth by Targeting Senescent Cells?

(2017) Peter L.J. de Keizer   TRENDS IN MOLECULAR MEDICINE

The PI3K/Akt pathway: a critical player in intervertebral disc degeneration

(2017) Zhi-Hua Ouyang et al.   Oncotarget

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

(2016) Chencheng Feng et al.   CELL CYCLE

A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1

(2016) Kumar K.J. Senthil et al.   Oncotarget

Curcumin: A Natural Lead for Potential New Drug Candidates

(2015) Ana Oliveira et al.   CURRENT MEDICINAL CHEMISTRY

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

(2014) Y Shi et al.   CELL DEATH AND DIFFERENTIATION

Painful, degenerating intervertebral discs up-regulate neurite sprouting and CGRP through nociceptive factors

(2014) Emerson Krock et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative

(2014) Claudio Oliveira et al.   MOLECULES

High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain

(2014) Rahul Gawri et al.   ARTHRITIS RESEARCH & THERAPY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

MiR-27a Regulates Apoptosis in Nucleus Pulposus Cells by Targeting PI3K

(2013) Gang Liu et al.   PLoS One

The Targets of Curcumin

(2012) Hongyu Zhou et al.   CURRENT DRUG TARGETS

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity

(2012) Marina Klawitter et al.   Journal of Inflammation-London

Low stability remedies the low bioavailability of curcumin

(2012) Liang Shen et al.   TRENDS IN MOLECULAR MEDICINE

Curcumin Modulates Nuclear Factor κB (NF-κB)-mediated Inflammation in Human Tenocytesin Vitro

(2011) Constanze Buhrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of antioxidant activity of vanillin by using multiple antioxidant assays

(2010) Akihiro Tai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

(2009) Jayaraj Ravindran et al.   AAPS Journal

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE