Nod-like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections

Type I interferon signaling and macrophages: a double-edged sword?

(2021) Barbara Adler et al.   Cellular & Molecular Immunology

Advances in Understanding Activation and Function of the NLRC4 Inflammasome

(2021) Balamurugan Sundaram et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Detection of Bacterial Membrane Vesicles by NOD-Like Receptors

(2021) Ella L. Johnston et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mediators of Metabolism: An Unconventional Role for NOD1 and NOD2

(2021) Megan T. Zangara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins

(2021) Jorge Alfonso León Machado et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NOD-like receptors in autoimmune diseases

(2021) Li Chen et al.   ACTA PHARMACOLOGICA SINICA

Focusing on the Cell Type Specific Regulatory Actions of NLRX1

(2021) Tünde Fekete et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of Type I Interferons on Susceptibility to Bacterial Pathogens

(2021) Adeline Peignier et al.   TRENDS IN MICROBIOLOGY

Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease

(2021) Julie E. Horowitz et al.   Scientific Reports

Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

(2021) Kshiti Phulphagar et al.   Cell Reports

The Trinity of cGAS, TLR9, and ALRs Guardians of the Cellular Galaxy Against Host-Derived Self-DNA

(2021) Vijay Kumar   Frontiers in Immunology

Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm

(2021) Jinghe Zhang et al.   Cellular & Molecular Immunology

An update on the regulatory mechanisms of NLRP3 inflammasome activation

(2021) Seungwha Paik et al.   Cellular & Molecular Immunology

The Critical Role of NLRP6 Inflammasome in Streptococcus pneumoniae Infection In Vitro and In Vivo

(2021) Dongyi Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pyroptosis: a new paradigm of cell death for fighting against cancer

(2021) Yixin Tan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells

(2021) Lama Tarayrah-Ibraheim et al.   Nature Communications

NLRP6 in host defense and intestinal inflammation

(2021) K. Venuprasad et al.   Cell Reports

Role of inflammasomes/pyroptosis and PANoptosis during fungal infection

(2021) Benoit Briard et al.   PLoS Pathogens

NLRC4 inhibits NLRP3 inflammasome and abrogates effective antifungal CD8+ T cell responses

(2021) Camila O.S. Souza et al.   iScience

The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia

(2021) Zengzhang Zheng et al.   SCIENCE

Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection

(2020) Michael Riedelberger et al.   Cell Host & Microbe

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

(2020) Ming He et al.   Cell Metabolism

Pyroptosis: The missing puzzle among innate and adaptive immunity crosstalk

(2020) Mahmood Y. Hachim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

(2020) Kohsuke Tsuchiya   MICROBIOLOGY AND IMMUNOLOGY

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

(2020) Annika Hausmann et al.   Mucosal Immunology

Mechanism and regulation of pyroptosis-mediated in cancer cell death

(2020) Jianwei Ruan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

NOD1 and NOD2 activation by diverse stimuli: a possible role for sensing pathogen-induced ER stress

(2020) Sharon K. Kuss-Duerkop et al.   INFECTION AND IMMUNITY

NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS

(2020) Xiao Man Wu et al.   JOURNAL OF IMMUNOLOGY

NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma

(2020) Hui Chen et al.   Molecular Neurodegeneration

Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation

(2020) Sandip Mukherjee et al.   NATURE IMMUNOLOGY

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Shelbi Christgen et al.   Frontiers in Cellular and Infection Microbiology

NLRP6 Plays an Important Role in Early Hepatic Immunopathology Caused by Schistosoma mansoni Infection

(2020) Rodrigo C. O. Sanches et al.   Frontiers in Immunology

Inflammasomes in Common Immune-Related Skin Diseases

(2020) Lili Tang et al.   Frontiers in Immunology

NLRP12 controls arthritis severity by acting as a checkpoint inhibitor of Th17 cell differentiation

(2020) Douglas Silva Prado et al.   FASEB JOURNAL

The microbiome and cytosolic innate immune receptors

(2020) Timur Liwinski et al.   IMMUNOLOGICAL REVIEWS

The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

(2020) Min Zheng et al.   IMMUNOLOGICAL REVIEWS

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

(2020) Min Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19

(2020) Jeremy K. Y. Yap et al.   JOURNAL OF IMMUNOLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium

(2020) Stephen B. Kovacs et al.   Cell Reports

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

(2020) Danping Zheng et al.   Cell Discovery

Interconnections among major forms of regulated cell death

(2020) Chaoyi Wu et al.   APOPTOSIS

HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection

(2020) Yu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP12 in innate immunity and inflammation

(2020) Shraddha Tuladhar et al.   MOLECULAR ASPECTS OF MEDICINE

ROS-mediated NLRP3 inflammasome activation participates in the response against Neospora caninum infection

(2020) Lu Li et al.   Parasites & Vectors

Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

(2020) SangJoon Lee et al.   TRENDS IN IMMUNOLOGY

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro

(2020) Anna Gritsenko et al.   Frontiers in Immunology

Inflammasomes and Childhood Autoimmune Diseases: A Review of Current Knowledge

(2020) Chin-An Yang et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

NLR in eXile: Emerging roles of NLRX1 in immunity and human disease

(2020) Robert J. Pickering et al.   IMMUNOLOGY

NLRP6 modulates neutrophil homeostasis in bacterial pneumonia-derived sepsis

(2020) Shanshan Cai et al.   Mucosal Immunology

The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6

(2020) Adam Sateriale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome

(2019) Renan V.H. de Carvalho et al.   Cell Reports

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

NLRP6 suppresses the inflammatory response of human periodontal ligament cells by inhibiting NF-κB and ERK signal pathways

(2019) W. L. Lu et al.   INTERNATIONAL ENDODONTIC JOURNAL

Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon

(2019) Xin Li et al.   IMMUNITY

NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25

(2019) Szu-Ting Chen et al.   Cell Host & Microbe

The Coming Decade of Cell Death Research: Five Riddles

(2019) Douglas R. Green   CELL

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

NLRP12 negatively modulates inducible nitric oxide synthase (iNOS) expression and tumor necrosis factor-α production in Porphyromonas gingivalis LPS-treated mouse macrophage cell line (RAW264.7)

(2019) Matsayapan Pudla et al.   INFLAMMATION RESEARCH

Type I interferon induced by TLR2-TLR4-MyD88-TRIF-IRF3 controls Mycobacterium abscessus subsp. abscessus persistence in murine macrophages via nitric oxide

(2019) Nanthapon Ruangkiattikul et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

(2019) Rudragouda Channappanavar et al.   JOURNAL OF CLINICAL INVESTIGATION

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

(2019) Sabrina Sofia Burgener et al.   Cell Reports

NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease

(2019) Pierre-Gregoire Coulon et al.   Frontiers in Immunology

Hyperactivation of the NLRP3 inflammasome protects mice against influenza A virus infection via IL-1β mediated neutrophil recruitment

(2019) Junling Niu et al.   CYTOKINE

Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis

(2019) Yanan An et al.   FASEB JOURNAL

ROS accumulation and associated cell death mediates susceptibility to Alternaria brassicae in Arabidopsis accessions

(2019) Sayanti Mandal et al.   PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY

Detrimental Effect of Type I IFNs During Acute Lung Infection With Pseudomonas aeruginosa Is Mediated Through the Stimulation of Neutrophil NETosis

(2019) Ekaterina Pylaeva et al.   Frontiers in Immunology

Activated NLR family pyrin domain containing 3 (NLRP3) inflammasome in keratinocytes promotes cutaneous T-cell response in patients with vitiligo

(2019) Shuli Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

(2019) Yan Lu et al.   SCIENCE

The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon

(2019) Renate Frantz et al.   mBio

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

(2019) Renan V. H. de Carvalho et al.   Nature Communications

NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function

(2019) Margaret A. Nagai-Singer et al.   Frontiers in Immunology

The Ubiquitin Code of NODs Signaling Pathways in Health and Disease

(2019) Rubén Julio Martínez-Torres et al.   Frontiers in Immunology

NOD Signaling and Cell Death

(2019) Valentin J. Heim et al.   Frontiers in Cell and Developmental Biology

Inhibition of type I interferon signaling abrogates early Mycobacterium bovis infection

(2019) Jie Wang et al.   BMC INFECTIOUS DISEASES

An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling

(2019) Alessandro Pagliuso et al.   Cell Host & Microbe

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

(2019) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-β Improves Sepsis-related Alveolar Macrophage Dysfunction and Postseptic Acute Respiratory Distress Syndrome–related Mortality

(2018) Takahiro Hiruma et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nontypeable Haemophilus influenzae DNA stimulates type I interferon expression via STING signaling pathway

(2018) Chang Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation

(2018) Kritarth Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection

(2018) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

(2018) Gabriel Sollberger et al.   DEVELOPMENTAL CELL

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effects of type I interferons in malaria

(2018) Ismail Sebina et al.   IMMUNOLOGY

Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction

(2018) Tengchuan Jin et al.   PLoS One

Exogenous Stimulation of Type I Interferon Protects Mice with Chronic Granulomatous Disease from Aspergillosis through Early Recruitment of Host-Protective Neutrophils into the Lung

(2018) Seyedmojtaba Seyedmousavi et al.   mBio

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

(2018) Lan H. Chu et al.   Nature Communications

The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection

(2018) Rafid Alhallaf et al.   Cell Reports

Association of NLRP1 and NLRP3 Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population

(2018) Pei Yu et al.   Biomed Research International

NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis

(2018) Jingyun Luan et al.   Frontiers in Immunology

NLRP3 Inflammasome and Caspase-1/11 Pathway Orchestrate Different Outcomes in the Host Protection Against Trypanosoma cruzi Acute Infection

(2018) Augusto F. Paroli et al.   Frontiers in Immunology

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis

(2018) Qingling Guo et al.   Frontiers in Immunology

NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis

(2018) C Guo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

RIP2 filament formation is required for NOD2 dependent NF-κB signalling

(2018) Erika Pellegrini et al.   Nature Communications

NLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function

(2018) Laxman Ghimire et al.   PLoS Pathogens

Type I interferons differentially modulate maternal host immunity to infection by Listeria monocytogenes and Salmonella enterica serovar Typhimurium during pregnancy

(2018) Gerard Agbayani et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection

(2018) Hideki Hara et al.   CELL

Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages

(2018) Angelica Montenegro Riestra et al.   Journal of Innate Immunity

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens

(2018) Sylvain Normand et al.   Nature Communications

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

(2018) Lydia Kasper et al.   Nature Communications

NLRX1 Facilitates Histoplasma capsulatum-Induced LC3-Associated Phagocytosis for Cytokine Production in Macrophages

(2018) Juin-Hua Huang et al.   Frontiers in Immunology

Parasite Recognition and Signaling Mechanisms in Innate Immune Responses to Malaria

(2018) D. Channe Gowda et al.   Frontiers in Immunology

The NLRC4 Inflammasome

(2017) Joseph A. Duncan et al.   IMMUNOLOGICAL REVIEWS

A noncanonical function of cGAMP in inflammasome priming and activation

(2017) Karen V. Swanson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LRRK2 promotes the activation of NLRC4 inflammasome duringSalmonellaTyphimurium infection

(2017) Weiwei Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis

(2017) Gwendolyn M. Clay et al.   JOURNAL OF IMMUNOLOGY

SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants

(2017) Meleri Jones et al.   JOURNAL OF MEDICAL VIROLOGY

NLRP6: A Multifaceted Innate Immune Sensor

(2017) Maayan Levy et al.   TRENDS IN IMMUNOLOGY

NOD1 and NOD2: Beyond Peptidoglycan Sensing

(2017) A. Marijke Keestra-Gounder et al.   TRENDS IN IMMUNOLOGY

CLEC5A is a critical receptor in innate immunity against Listeria infection

(2017) Szu-Ting Chen et al.   Nature Communications

NLRP3 inflammasome is a key player in human vulvovaginal disease caused by Candida albicans

(2017) Elena Roselletti et al.   Scientific Reports

Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome

(2017) Danielle P. A. Mascarenhas et al.   PLoS Pathogens

Canonical Stimulation of the NLRP3 Inflammasome by Fungal Antigens Links Innate and Adaptive B-Lymphocyte Responses by Modulating IL-1β and IgM Production

(2017) Mohamed F. Ali et al.   Frontiers in Immunology

Identification of rare genetic variation of NLRP1 gene in familial multiple sclerosis

(2017) Ales Maver et al.   Scientific Reports

The H7N9 influenza A virus infection results in lethal inflammation in the mammalian host via the NLRP3-caspase-1 inflammasome

(2017) Rongrong Ren et al.   Scientific Reports

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

(2016) Franklin L. Zhong et al.   CELL

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses

(2016) Haitao Guo et al.   Cell Host & Microbe

NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus

(2016) Tatiana N. Silveira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling

(2016) Alina Zamoshnikova et al.   IMMUNOBIOLOGY

Type I IFN Does Not Promote Susceptibility to FoodborneListeria monocytogenes

(2016) Michelle G. Pitts et al.   JOURNAL OF IMMUNOLOGY

Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

(2016) Elisa Deriu et al.   PLoS Pathogens

NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8+ T lymphocytes

(2016) Galaxia M. Rodriguez et al.   OncoImmunology

NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis

(2016) Mari H. Tervaniemi et al.   Scientific Reports

Nucleotide-binding oligomerization domain-containing protein 2 prompts potent inflammatory stimuli during Neospora caninum infection

(2016) Marcela Davoli-Ferreira et al.   Scientific Reports

Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation

(2015) Prajwal Gurung et al.   AMERICAN JOURNAL OF PATHOLOGY

Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice

(2015) Benjamin Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis

(2015) Sunny Malhotra et al.   BRAIN

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

(2015) Christina Antonopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin

(2015) Jens Kortmann et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NOD-Like Receptors: Versatile Cytosolic Sentinels

(2015) Vinicius Motta et al.   PHYSIOLOGICAL REVIEWS

NLRP12 provides a critical checkpoint for osteoclast differentiation

(2015) Jennifer L. Krauss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nlrp6 regulates intestinal antiviral innate immunity

(2015) Penghua Wang et al.   SCIENCE

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

(2015) Seokwon Kang et al.   Nature Communications

PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection

(2015) Marina Tiemi Shio et al.   PLoS Neglected Tropical Diseases

The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction

(2015) Leanne Mortimer et al.   PLoS Pathogens

Mitochondrial DNA in the regulation of innate immune responses

(2015) Chunju Fang et al.   Protein & Cell

Editorial: NLR-Protein Functions in Immunity

(2015) Jörg H. Fritz et al.   Frontiers in Immunology

Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2

(2014) Yun-Gi Kim et al.   Cell Host & Microbe

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

(2014) R. Allam et al.   EMBO REPORTS

NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING

(2014) Lu Zhang et al.   IMMUNITY

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

Emerging Significance of NLRs in Inflammatory Bowel Disease

(2014) Beckley K. Davis et al.   INFLAMMATORY BOWEL DISEASES

Blau Syndrome–AssociatedNod2Mutation Alters Expression of Full-Length NOD2 and Limits Responses to Muramyl Dipeptide in Knock-in Mice

(2014) Jae Dugan et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen,Candida albicans

(2014) Sandhya Ganesan et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

The multifaceted nature of NLRP12

(2014) Sinem Tuncer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nod-Like Receptor X-1 Is Required for Rhinovirus-Induced Barrier Dysfunction in Airway Epithelial Cells

(2014) B. L. Unger et al.   JOURNAL OF VIROLOGY

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

NLRP12- associated autoinflammatory disorder: case report

(2014) Giuseppina Volpe et al.   Pediatric Rheumatology

NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein

(2014) J. Jaworska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential roles of nucleotide-binding oligomerization domain 2 in the pathogenesis of systemic lupus erythematosus

(2014) Jing Li et al.   RHEUMATOLOGY INTERNATIONAL

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

Insights into the molecular basis of the NOD2 signalling pathway

(2014) J. P. Boyle et al.   Open Biology

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

(2014) Marco A. Ataide et al.   PLoS Pathogens

The role of the inflammatory microenvironment in thyroid carcinogenesis

(2013) Lucas Leite Cunha et al.   ENDOCRINE-RELATED CANCER

Nucleotide-Binding Oligomerization Domain 2 Signaling Promotes Hyperresponsive Macrophages and Colitis in IL-10-Deficient Mice

(2013) J. Jamontt et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein

(2013) M. Rayamajhi et al.   JOURNAL OF IMMUNOLOGY

Roles of NLRP10 in innate and adaptive immunity

(2013) Anna Damm et al.   MICROBES AND INFECTION

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

(2013) Anna Sokolovska et al.   NATURE IMMUNOLOGY

Correction: Characterization of NLRP12 during the In Vivo Host Immune Response to Klebsiella pneumoniae and Mycobacterium tuberculosis

(2013) Irving C. Allen et al.   PLoS One

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

(2013) M. H. Zaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production

(2013) Virginia M. Gonçalves et al.   PLoS Neglected Tropical Diseases

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection

(2013) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

The Interplay between NLRs and Autophagy in Immunity and Inflammation

(2013) Leticia A. M. Carneiro et al.   Frontiers in Immunology

Beneficial and Detrimental Roles of NLRs in Carcinogenesis

(2013) Ann M. Janowski et al.   Frontiers in Immunology

Unsolved Mysteries in NLR Biology

(2013) Christopher Lupfer et al.   Frontiers in Immunology

Polimorphisms in Inflammasome Genes Are Involved in the Predisposition to Systemic Lupus Erythematosus

(2012) Alessandra Pontillo et al.   AUTOIMMUNITY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

CIITA gene variants are associated with rheumatoid arthritis in Scandinavian populations

(2012) M C Eike et al.   GENES AND IMMUNITY

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

(2012) Yu Lei et al.   IMMUNITY

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Regulation of Class I Major Histocompatibility Complex (MHC) by Nucleotide-binding Domain, Leucine-rich Repeat-containing (NLR) Proteins

(2012) Gregory R. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Nlrp10 Is Essential for Protective Antifungal Adaptive Immunity against Candida albicans

(2012) S. Joly et al.   JOURNAL OF IMMUNOLOGY

Integrative inflammasome activity in the regulation of intestinal mucosal immune responses

(2012) E Elinav et al.   Mucosal Immunology

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells

(2012) Stephanie C. Eisenbarth et al.   NATURE

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

(2012) Nirmal Robinson et al.   NATURE IMMUNOLOGY

Opposing Roles for Interferon Regulatory Factor-3 (IRF-3) and Type I Interferon Signaling during Plague

(2012) Ami A. Patel et al.   PLoS Pathogens

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

NLRX1/NOD5 deficiency does not affect MAVS signalling

(2011) M Rebsamen et al.   CELL DEATH AND DIFFERENTIATION

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

(2011) Juliane Lippmann et al.   CELLULAR MICROBIOLOGY

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Type I Interferons Increase Host Susceptibility to Trypanosoma cruzi Infection

(2011) Anne-Danielle C. Chessler et al.   INFECTION AND IMMUNITY

Distinct Roles for Nod2 Protein and Autocrine Interleukin-1β in Muramyl Dipeptide-induced Mitogen-activated Protein Kinase Activation and Cytokine Secretion in Human Macrophages

(2011) Matija Hedl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell death and infection: A double-edged sword for host and pathogen survival

(2011) Hiroshi Ashida et al.   JOURNAL OF CELL BIOLOGY

De novo 19q13.42 duplications involving NLRP gene cluster in a patient with systemic-onset juvenile idiopathic arthritis

(2011) Hiromi Tadaki et al.   JOURNAL OF HUMAN GENETICS

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Two SNPs inNLRP3gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil

(2010) A. Pontillo et al.   AUTOIMMUNITY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

(2010) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice

(2010) R. Imamura et al.   JOURNAL OF IMMUNOLOGY

Type I IFN Signaling Constrains IL-17A/F Secretion by    T Cells during Bacterial Infections

(2010) T. Henry et al.   JOURNAL OF IMMUNOLOGY

The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila

(2010) Mariana S. Frutuoso et al.   MICROBES AND INFECTION

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

(2009) Maria Kaparakis et al.   CELLULAR MICROBIOLOGY

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

(2009) D. Arnoult et al.   JOURNAL OF CELL SCIENCE

Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance against Trypanosoma cruzi Infection

(2009) G. K. Silva et al.   JOURNAL OF IMMUNOLOGY

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Uncovering the evolutionary history of innate immunity: The simple metazoan Hydra uses epithelial cells for host defence

(2008) Thomas C.G. Bosch et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes

(2008) N F Magitta et al.   GENES AND IMMUNITY

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

Type I Interferon Signaling Exacerbates Chlamydia muridarum Genital Infection in a Murine Model

(2008) U. M. Nagarajan et al.   INFECTION AND IMMUNITY

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA