NLR in eXile: Emerging roles of NLRX1 in immunity and human disease
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
NLR in eXile: Emerging roles of NLRX1 in immunity and human disease
Authors
Keywords
-
Journal
IMMUNOLOGY
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-12-14
DOI
10.1111/imm.13291
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Listeria monocytogenes Exploits Mitochondrial Contact Site and Cristae Organizing System Complex Subunit Mic10 To Promote Mitochondrial Fragmentation and Cellular Infection
- (2020) Filipe Carvalho et al. mBio
- The Roles of the NLRP3 Inflammasome in Neurodegenerative and Metabolic Diseases and in Relevant Advanced Therapeutic Interventions
- (2020) Rameez Hassan Pirzada et al. Genes
- DJ-1 exerts anti-inflammatory effects and regulates NLRX1-TRAF6 via SHP-1 in stroke
- (2020) Li Peng et al. Journal of Neuroinflammation
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
- (2020) David E. Gordon et al. NATURE
- Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response
- (2020) Zhihua Ren et al. Frontiers in Immunology
- Focus on the Role of NLRP3 Inflammasome in Diseases
- (2020) Roberta Fusco et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis
- (2020) Bridget Kastelberg et al. PLoS Pathogens
- Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury
- (2020) Timothy E. Beach et al. Redox Biology
- NLRX1 does not play a role in diabetes nor the development of diabetic nephropathy induced by multiple low doses of streptozotocin
- (2019) Angelique M. L. Scantlebery et al. PLoS One
- Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing
- (2019) Yifan Zhang et al. NATURE IMMUNOLOGY
- Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon
- (2019) Xin Li et al. IMMUNITY
- NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer
- (2019) Fernando J Velloso et al. BIOSCIENCE REPORTS
- NLRX1 regulates TNF-α-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells
- (2019) Kritarth Singh et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury
- (2019) Ram Kuwar et al. Journal of Neuroinflammation
- NLRP3 inhibitors stoke anti-inflammatory ambitions
- (2019) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- LC3-associated phagocytosis - The highway to hell for phagocytosed microbes
- (2019) Marc Herb et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes
- (2019) Shaimaa Mahmoud et al. Cells
- NLRX1 alleviates lipopolysaccharide-induced apoptosis and inflammation in chondrocytes by suppressing the activation of NF-κB signaling
- (2019) Ding Ma et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Neuroinflammation: friend and foe for ischemic stroke
- (2019) Richard L. Jayaraj et al. Journal of Neuroinflammation
- Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
- (2019) Morgan Brisse et al. Frontiers in Immunology
- NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity
- (2019) Marjan Gharagozloo et al. PLOS BIOLOGY
- Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1
- (2019) Andrew Leber et al. DRUG AND CHEMICAL TOXICOLOGY
- Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells
- (2019) Andrew Leber et al. JOURNAL OF IMMUNOLOGY
- NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function
- (2019) Margaret A. Nagai-Singer et al. Frontiers in Immunology
- HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING
- (2019) Xiaobo Luo et al. JOURNAL OF CLINICAL INVESTIGATION
- Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome
- (2018) Lotte Kors et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation
- (2018) Kritarth Singh et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
- (2018) Sarah Pickles et al. CURRENT BIOLOGY
- NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells
- (2018) Bo Hu et al. Journal of Hematology & Oncology
- The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1
- (2018) Samuel A. Killackey et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Innate immunity as a target for acute cardioprotection
- (2018) Coert J Zuurbier et al. CARDIOVASCULAR RESEARCH
- Genome-wide CRISPR-Cas9 viability screen reveals genes involved in TNF-α-induced apoptosis of human umbilical vein endothelial cells
- (2018) Meng Cai et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
- (2018) Richard Gordon et al. Science Translational Medicine
- NLRX1 Facilitates Histoplasma capsulatum-Induced LC3-Associated Phagocytosis for Cytokine Production in Macrophages
- (2018) Juin-Hua Huang et al. Frontiers in Immunology
- Interactions of TRAF6 and NLRX1 gene polymorphisms with environmental factors on the susceptibility of type 2 diabetes mellitus vascular complications in a southern Han Chinese population
- (2017) Chengli Zeng et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity
- (2017) Geurt Stokman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- NLRX1 Regulates Effector and Metabolic Functions of CD4+T Cells
- (2017) Andrew Leber et al. JOURNAL OF IMMUNOLOGY
- Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling following Brain Injury
- (2017) Michelle H. Theus et al. JOURNAL OF IMMUNOLOGY
- LC3-Associated Phagocytosis and Inflammation
- (2017) Bradlee L. Heckmann et al. JOURNAL OF MOLECULAR BIOLOGY
- NLRX1 Mediates MAVS Degradation To Attenuate the Hepatitis C Virus-Induced Innate Immune Response through PCBP2
- (2017) Yuwen Qin et al. JOURNAL OF VIROLOGY
- The NLRP3 inflammasome in acute myocardial infarction
- (2017) Stefano Toldo et al. Nature Reviews Cardiology
- Listeria monocytogenes: towards a complete picture of its physiology and pathogenesis
- (2017) Lilliana Radoshevich et al. NATURE REVIEWS MICROBIOLOGY
- Listeriolysin O: from bazooka to Swiss army knife
- (2017) Suzanne E. Osborne et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation
- (2017) Hyuk Soon Kim et al. Nature Communications
- NLRC and NLRX gene family mRNA expression and prognostic value in hepatocellular carcinoma
- (2017) Xiangkun Wang et al. Cancer Medicine
- Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain
- (2017) Nemat Khan et al. INFLAMMOPHARMACOLOGY
- Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys
- (2016) Dan H. Barouch et al. CELL
- NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses
- (2016) Haitao Guo et al. Cell Host & Microbe
- Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure
- (2016) Sheryl Coutermarsh-Ott et al. JOURNAL OF GENERAL VIROLOGY
- NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation
- (2016) Hongyan Li et al. MOLECULAR IMMUNOLOGY
- NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-κB signaling
- (2016) Sheryl Coutermarsh-Ott et al. Oncotarget
- NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation
- (2016) Ivan Tattoli et al. Cell Reports
- The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals
- (2016) A. Alicia Koblansky et al. Cell Reports
- Prion-like Aggregation of Mitochondrial Antiviral Signaling Protein in Lupus Patients Is Associated With Increased Levels of Type I Interferon
- (2016) Wen-Hai Shao et al. Arthritis & Rheumatology
- Histoplasma capsulatum, lung infection and immunity
- (2015) Michael C Horwath et al. Future Microbiology
- Suppression of NLRX1 in chronic obstructive pulmonary disease
- (2015) Min-Jong Kang et al. JOURNAL OF CLINICAL INVESTIGATION
- NLRP3 inflammasome and its inhibitors: a review
- (2015) Bo-Zong Shao et al. Frontiers in Pharmacology
- Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection
- (2015) Casandra W. Philipson et al. PLoS One
- Modeling-Enabled Characterization of Novel NLRX1 Ligands
- (2015) Pinyi Lu et al. PLoS One
- Interferon-Stimulated Genes: A Complex Web of Host Defenses
- (2014) William M. Schneider et al. Annual Review of Immunology
- Mechanisms and Functions of Inflammasomes
- (2014) Mohamed Lamkanfi et al. CELL
- TLR ligands upregulate RIG-I expression in human plasmacytoid dendritic cells in a type I IFN-independent manner
- (2014) Attila Szabo et al. IMMUNOLOGY AND CELL BIOLOGY
- The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis
- (2014) Fraser Soares et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
- (2014) Edward T. Chouchani et al. NATURE
- The NOD-Like Receptor Signalling Pathway in Helicobacter pylori Infection and Related Gastric Cancer: A Case-Control Study and Gene Expression Analyses
- (2014) Natalia Castaño-Rodríguez et al. PLoS One
- NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein
- (2014) J. Jaworska et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity
- (2014) Takuma Yoshizumi et al. Nature Communications
- Determinants of virulence of influenza A virus
- (2013) E. J. A. Schrauwen et al. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
- The Nucleotide-binding Leucine-rich Repeat (NLR) Family Member NLRX1 Mediates Protection against Experimental Autoimmune Encephalomyelitis and Represses Macrophage/Microglia-induced Inflammation
- (2013) Timothy K. Eitas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deficiency in Hematopoietic Phosphatase Ptpn6/Shp1 Hyperactivates the Innate Immune System and Impairs Control of Bacterial Infections in Zebrafish Embryos
- (2013) Z. Kanwal et al. JOURNAL OF IMMUNOLOGY
- The involvement of NLRX1 and NLRP3 in the development of nonalcoholic steatohepatitis in mice
- (2013) Yu-Gang Wang et al. Journal of the Chinese Medical Association
- DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1
- (2013) Jong-hyeon Kim et al. NEUROBIOLOGY OF DISEASE
- Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism
- (2013) Z. Hu et al. SCIENCE
- Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
- (2013) D. Gao et al. SCIENCE
- IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
- (2013) Helen M. Lazear et al. PLoS Pathogens
- Functions of NOD-Like Receptors in Human Diseases
- (2013) Yifei Zhong et al. Frontiers in Immunology
- Rare inborn errors associated with chronic hepatitis B virus infection*
- (2012) Qiang Zhao et al. HEPATOLOGY
- Structure and Functional Characterization of the RNA-Binding Element of the NLRX1 Innate Immune Modulator
- (2012) Minsun Hong et al. IMMUNITY
- The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy
- (2012) Yu Lei et al. IMMUNITY
- NLRX1 does not inhibit MAVS-dependent antiviral signalling
- (2012) Fraser Soares et al. Innate Immunity
- MyD88 Drives the IFN- Response to Lactobacillus acidophilus in Dendritic Cells through a Mechanism Involving IRF1, IRF3, and IRF7
- (2012) G. Weiss et al. JOURNAL OF IMMUNOLOGY
- Hidden Killers: Human Fungal Infections
- (2012) G. D. Brown et al. Science Translational Medicine
- IRF8 and IRF3 cooperatively regulate rapid interferon- induction in human blood monocytes
- (2011) P. Li et al. BLOOD
- NLRX1/NOD5 deficiency does not affect MAVS signalling
- (2011) M Rebsamen et al. CELL DEATH AND DIFFERENTIATION
- NOD So Fast: NLRX1 Puts the Brake on Inflammation
- (2011) Kislay Parvatiyar et al. IMMUNITY
- NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK
- (2011) Xiaojun Xia et al. IMMUNITY
- NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways
- (2011) Irving C. Allen et al. IMMUNITY
- Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication
- (2011) Chiara Orlandi et al. Journal of Translational Medicine
- Innate immune signaling in cardiac ischemia
- (2011) Fatih Arslan et al. Nature Reviews Cardiology
- Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus
- (2011) S. M. Horner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Listeria monocytogenestransiently alters mitochondrial dynamics during infection
- (2011) Fabrizia Stavru et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
- (2010) L. E. Wroblewski et al. CLINICAL MICROBIOLOGY REVIEWS
- Enhancement of Reactive Oxygen Species Production and Chlamydial Infection by the Mitochondrial Nod-like Family Member NLRX1
- (2010) Ali A. Abdul-Sater et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Influenza A Virus Protein PB1-F2 Exacerbates IFN- Expression of Human Respiratory Epithelial Cells
- (2010) R. Le Goffic et al. JOURNAL OF IMMUNOLOGY
- NLRC5 Limits the Activation of Inflammatory Pathways
- (2010) S. Benko et al. JOURNAL OF IMMUNOLOGY
- An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix
- (2009) D. Arnoult et al. JOURNAL OF CELL SCIENCE
- Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication
- (2008) Renate König et al. CELL
- NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production
- (2008) Ivan Tattoli et al. EMBO REPORTS
- NLRX1 is a regulator of mitochondrial antiviral immunity
- (2008) Chris B. Moore et al. NATURE
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started