Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19

Dehydrocostus lactone inhibits NLRP3 inflammasome activation by blocking ASC oligomerization and prevents LPS-mediated inflammation in vivo

(2020) Yuanyuan Chen et al.   CELLULAR IMMUNOLOGY

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

(2020) Jasper Fuk-Woo Chan et al.   Emerging Microbes & Infections

NLRP3 Inflammasome—A Key Player in Antiviral Responses

(2020) Chunyuan Zhao et al.   Frontiers in Immunology

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(2020) Furong Qi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Weak Induction of Interferon Expression by SARS-CoV-2 Supports Clinical Trials of Interferon Lambda to Treat Early COVID-19

(2020) Thomas R O’Brien et al.   CLINICAL INFECTIOUS DISEASES

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

COVID-19 and emerging viral infections: The case for interferon lambda

(2020) Ludmila Prokunina-Olsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Type 1 interferons as a potential treatment against COVID-19

(2020) Erwan Sallard et al.   ANTIVIRAL RESEARCH

Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV

(2019) Yuting Jiang et al.   Viruses-Basel

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host

(2019) Matae Ahn et al.   Nature Microbiology

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

(2019) I-Yin Chen et al.   Frontiers in Microbiology

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

(2019) Congqing Wu et al.   IMMUNITY

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases

(2019) Na An et al.   Frontiers in Immunology

Gasdermin D activity in inflammation and host defense

(2019) Judy Lieberman et al.   Science Immunology

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

A Pilot Study of Tranilast for Cardiomyopathy of Muscular Dystrophy

(2018) Tsuyoshi Matsumura et al.   INTERNAL MEDICINE

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner

(2018) SangJoon Lee et al.   JOURNAL OF VIROLOGY

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

(2018) Jinyong Wang et al.   PLoS Pathogens

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

(2018) Shalini M Krishnan et al.   CARDIOVASCULAR RESEARCH

Kawasaki disease: epidemiology and the lessons from it

(2017) Yosikazu Nakamura   International Journal of Rheumatic Diseases

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes

(2017) Ryan D. Molony et al.   Science Signaling

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Role of the inflammasome in chronic obstructive pulmonary disease (COPD)

(2017) Chiara Colarusso et al.   Oncotarget

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes

(2017) Ryan D. Molony et al.   Science Signaling

Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis

(2017) Talita P. Domiciano et al.   Scientific Reports

Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure

(2016) Sheryl Coutermarsh-Ott et al.   JOURNAL OF GENERAL VIROLOGY

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

(2016) P. S. Pillai et al.   SCIENCE

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism

(2016) Xingying He et al.   Scientific Reports

RNase L Activates the NLRP3 Inflammasome during Viral Infections

(2015) Arindam Chakrabarti et al.   Cell Host & Microbe

Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-κB Pathway

(2015) Eun Jeong Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Kawasaki disease: insights into pathogenesis and approaches to treatment

(2015) Stanford T. Shulman et al.   Nature Reviews Rheumatology

Tranilast: A review of its therapeutic applications

(2015) Sara Darakhshan et al.   PHARMACOLOGICAL RESEARCH

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

(2014) Xiaqiong Wang et al.   NATURE IMMUNOLOGY

High dose anakinra for treatment of severe neonatal Kawasaki disease: a case report

(2014) Ashley Shafferman et al.   Pediatric Rheumatology

Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease

(2014) Long Truong Hoang et al.   Genome Medicine

Activation of NLRP3 Inflammasome in Alveolar Macrophages Contributes to Mechanical Stretch-Induced Lung Inflammation and Injury

(2013) J. Wu et al.   JOURNAL OF IMMUNOLOGY

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

A Virological View of Innate Immune Recognition

(2012) Akiko Iwasaki   Annual Review of Microbiology

Interleukin-1β Is Crucial for the Induction of Coronary Artery Inflammation in a Mouse Model of Kawasaki Disease

(2012) Youngho Lee et al.   CIRCULATION

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Influenza enhances caspase-1 in bronchial epithelial cells from asthmatic volunteers and is associated with pathogenesis

(2012) Rebecca N. Bauer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

(2012) Jakob von Moltke et al.   NATURE

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Mitogen-Activated Protein Kinase Kinase 6 Mediates Mechanical Stretch-Induced High-Mobility Group Box 1 Protein Expression in Pulmonary Alveolar Epithelial Cells

(2011) Ning Ding et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY