Journal
TRENDS IN MICROBIOLOGY
Volume 29, Issue 9, Pages 823-835Publisher
CELL PRESS
DOI: 10.1016/j.tim.2021.01.007
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Funding
- National Institutes of Health (NIH) [R01HL134870]
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This review discusses recent literature that provides new insights into the mechanisms of how type I IFN signaling exerts its effects on the outcome of infection from the host's point of view. The identified mechanisms have been wide and varied between pathogens.
Interferons (IFNs) are a broad class of cytokines that have multifaceted roles. Type I IFNs have variable effects when it comes to host susceptibility to bacterial infections, that is, the resulting outcomes can be either protective or deleterious. The mechanisms identified to date have been wide and varied between pathogens. In this review, we discuss recent literature that provides new insights into the mechanisms of how type I IFN signaling exerts its effects on the outcome of infection from the host's point of view.
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