Pyroptosis: a new paradigm of cell death for fighting against cancer
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Title
Pyroptosis: a new paradigm of cell death for fighting against cancer
Authors
Keywords
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Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 40, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-05-03
DOI
10.1186/s13046-021-01959-x
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Note: Only part of the references are listed.- NINJ1 mediates plasma membrane rupture during lytic cell death
- (2021) Nobuhiko Kayagaki et al. NATURE
- Release mechanisms of major DAMPs
- (2021) Atsushi Murao et al. APOPTOSIS
- Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes
- (2021) Kohsuke Tsuchiya et al. Cell Reports
- Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis
- (2020) Kun Wang et al. CELL
- The role of Caspase-1/GSDMD-mediated pyroptosis in Taxol-induced cell death and a Taxol-resistant phenotype in nasopharyngeal carcinoma regulated by autophagy
- (2020) Xianyao Wang et al. CELL BIOLOGY AND TOXICOLOGY
- Combining microenvironment normalization strategies to improve cancer immunotherapy
- (2020) Fotios Mpekris et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers
- (2020) Nina Kozlova et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome
- (2020) Yuying Liu et al. Science Immunology
- Acquired Resistance to Immune Checkpoint Inhibitors
- (2020) Adam J. Schoenfeld et al. CANCER CELL
- Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis
- (2020) Zhaodi Zheng et al. CELL CYCLE
- The Promise of Combining Radiation Therapy With Immunotherapy
- (2020) Justin C. Jagodinsky et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Gasdermin E suppresses tumour growth by activating anti-tumour immunity
- (2020) Zhibin Zhang et al. NATURE
- A bioorthogonal system reveals antitumour immune function of pyroptosis
- (2020) Qinyang Wang et al. NATURE
- FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
- (2020) Jun Jacob Hu et al. NATURE IMMUNOLOGY
- Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
- (2020) Zhiwei Zhou et al. SCIENCE
- Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate
- (2020) Lei Hu et al. Cell Death & Disease
- Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells
- (2020) Xiaorui Yang et al. Cell Death & Disease
- N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
- (2020) Mausita Karmakar et al. Nature Communications
- Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming
- (2020) Margaret M. McDaniel et al. Cell Reports
- NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy
- (2020) Cheng Zeng et al. Redox Biology
- Lobaplatin induces pyroptosis through regulating cIAP1/2, Ripoptosome and ROS in nasopharyngeal carcinoma
- (2020) Zide Chen et al. BIOCHEMICAL PHARMACOLOGY
- Priming the tumor immune microenvironment with chemo(radio)therapy: A systematic review across tumor types
- (2020) Tom van den Ende et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor’s arsenal
- (2020) Clara S. Mundry et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial
- (2020) Shuhong Wang et al. CLINICAL CANCER RESEARCH
- Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
- (2020) Rong Tang et al. Journal of Hematology & Oncology
- A novel chimeric PD1-NKG2D-41BB receptor enhances antitumor activity of NK92 cells against human lung cancer H1299 cells by triggering pyroptosis
- (2020) Chengui Lu et al. MOLECULAR IMMUNOLOGY
- Radiation causes tissue damage by dysregulating inflammasome–gasdermin D signaling in both host and transplanted cells
- (2020) Jianqiu Xiao et al. PLOS BIOLOGY
- Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity
- (2020) Wanjun Ma et al. Frontiers in Cell and Developmental Biology
- Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy
- (2020) Pengfei Zhao et al. BIOMATERIALS
- PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
- (2020) Junwei Hou et al. NATURE CELL BIOLOGY
- Indirect regulation of HMGB1 release by gasdermin D
- (2020) Allen Volchuk et al. Nature Communications
- Radiotherapy-Mediated Immunomodulation and Anti-Tumor Abscopal Effect Combining Immune Checkpoint Blockade
- (2020) Xinrui Zhao et al. Cancers
- A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma
- (2019) Mengjiao Wu et al. EBioMedicine
- Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells
- (2019) Junhui Yu et al. Cell Death & Disease
- MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis
- (2019) Jiujie Cui et al. MOLECULAR CANCER RESEARCH
- A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization
- (2019) Miguel F. Sanmamed et al. CELL
- Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation
- (2019) Cheng-cheng Zhang et al. APOPTOSIS
- Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis
- (2019) Lu Wang et al. CANCER LETTERS
- Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
- (2019) Xingzhe Ma et al. Cell Metabolism
- The emerging roles of inflammasome‐dependent cytokines in cancer development
- (2019) Hanne Van Gorp et al. EMBO REPORTS
- Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
- (2019) Corey Rogers et al. Nature Communications
- High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity
- (2019) Veronica M. Ringel-Scaia et al. EBioMedicine
- The Tumor Microenvironment Innately Modulates Cancer Progression
- (2019) Dominique C. Hinshaw et al. CANCER RESEARCH
- Caspase-1 initiates apoptosis in the absence of gasdermin D
- (2019) Kohsuke Tsuchiya et al. Nature Communications
- The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection
- (2019) Cheng-Bei Zhou et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Treg-mediated acquired resistance to immune checkpoint inhibitors
- (2019) Reem Saleh et al. CANCER LETTERS
- Mucosal Biomarker of Innate Immune Activation Predicts Response to Vedolizumab in Crohn’s Disease
- (2019) Mark T Osterman et al. INFLAMMATORY BOWEL DISEASES
- Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations
- (2019) Anqi Lin et al. Molecular Cancer
- The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer
- (2019) Man Wang et al. Cancers
- Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial
- (2019) J M Weiss et al. ANNALS OF ONCOLOGY
- The Diversification of Cell Death and Immunity: Memento Mori
- (2019) Arnaud J. Legrand et al. MOLECULAR CELL
- Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers
- (2019) Jin-Xuan Fan et al. NANO LETTERS
- Neutrophil Extracellular Traps in Host Defense
- (2019) Sabrina Sofia Burgener et al. Cold Spring Harbor Perspectives in Biology
- 5-Androstenediol prevents radiation injury in mice by promoting NF-κB signaling and inhibiting AIM2 inflammasome activation
- (2019) Tiancong Wu et al. BIOMEDICINE & PHARMACOTHERAPY
- Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy
- (2019) Xu Lei et al. CANCER LETTERS
- Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME
- (2019) Xinbin Zheng et al. LIFE SCIENCES
- Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis
- (2019) Jian Gao et al. Cell Death & Disease
- Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis
- (2019) Dan A. Erkes et al. Cancer Discovery
- Mechanisms of resistance to immune checkpoint inhibitors
- (2018) Russell W Jenkins et al. BRITISH JOURNAL OF CANCER
- T Cell Dysfunction in Cancer
- (2018) Daniela S. Thommen et al. CANCER CELL
- Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance
- (2018) Paula Jaime-Sánchez et al. CELL DEATH AND DIFFERENTIATION
- Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape
- (2018) Max D. Wellenstein et al. IMMUNITY
- The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
- (2018) Charles L. Evavold et al. IMMUNITY
- Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice
- (2018) Bing Xu et al. JOURNAL OF HEPATOLOGY
- NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass
- (2018) Lei Hou et al. LABORATORY INVESTIGATION
- DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia
- (2018) Darren C. Johnson et al. NATURE MEDICINE
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
- (2018) Jie Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity
- (2018) Marka R. Crittenden et al. Scientific Reports
- Efficacy of metformin in combination with immune checkpoint inhibitors (anti-PD-1/anti-CTLA-4) in metastatic malignant melanoma
- (2018) Muhammad Zubair Afzal et al. Journal for ImmunoTherapy of Cancer
- Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model
- (2018) Yuri Kosinsky et al. Journal for ImmunoTherapy of Cancer
- Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation
- (2018) Bettina L. Lee et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1
- (2018) Jong-Ho Cha et al. MOLECULAR CELL
- Cryo-EM structure of the gasdermin A3 membrane pore
- (2018) Jianbin Ruan et al. NATURE
- Efferocytosis in the tumor microenvironment
- (2018) Thomas A. Werfel et al. Seminars in Immunopathology
- Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
- (2018) Pontus Orning et al. SCIENCE
- The renaissance of anti-neoplastic immunity from tumor cell demise
- (2017) Yuting Ma et al. IMMUNOLOGICAL REVIEWS
- Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment
- (2017) Sushil Kumar et al. IMMUNOLOGICAL REVIEWS
- The future of immune checkpoint cancer therapy after PD-1 and CTLA-4
- (2017) Andrew W Hahn et al. Immunotherapy
- In Retrospect: The inflammasome turns 15
- (2017) Mohamed Lamkanfi et al. NATURE
- Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
- (2017) Yupeng Wang et al. NATURE
- Gasdermins: Effectors of Pyroptosis
- (2017) Stephen B. Kovacs et al. TRENDS IN CELL BIOLOGY
- Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
- (2017) Corey Rogers et al. Nature Communications
- An essential role for functional lysosomes in ferroptosis of cancer cells
- (2016) S. Torii et al. BIOCHEMICAL JOURNAL
- Immune suppressive mechanisms in the tumor microenvironment
- (2016) David H Munn et al. CURRENT OPINION IN IMMUNOLOGY
- GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
- (2016) Lorenzo Sborgi et al. EMBO JOURNAL
- The Promise of the Abscopal Effect and the Future of Trials Combining Immunotherapy and Radiation Therapy
- (2016) C. Bryce Johnson et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression
- (2016) Lena Seifert et al. NATURE
- Pore-forming activity and structural autoinhibition of the gasdermin family
- (2016) Jingjin Ding et al. NATURE
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- Ionic immune suppression within the tumour microenvironment limits T cell effector function
- (2016) Robert Eil et al. NATURE
- Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis
- (2016) Boris Strilic et al. NATURE
- DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis
- (2016) Marian C Okondo et al. Nature Chemical Biology
- Damage-associated molecular patterns in cancer: a double-edged sword
- (2016) C Hernandez et al. ONCOGENE
- An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
- (2016) Ivan Zanoni et al. SCIENCE
- Mechanism and Regulation of NLRP3 Inflammasome Activation
- (2016) Yuan He et al. TRENDS IN BIOCHEMICAL SCIENCES
- Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia
- (2016) Nicole E. Scharping et al. Cancer Immunology Research
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- Effects of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes
- (2015) Yohko Nakagawa et al. IMMUNOLOGY LETTERS
- An immunological view of chemotherapy
- (2015) Kangla Tsung et al. Immunotherapy
- Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial
- (2015) Encouse B Golden et al. LANCET ONCOLOGY
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- The diverse role of RIP kinases in necroptosis and inflammation
- (2015) John Silke et al. NATURE IMMUNOLOGY
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells
- (2015) N. Yatim et al. SCIENCE
- The future of immune checkpoint therapy
- (2015) P. Sharma et al. SCIENCE
- Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
- (2015) Elena Viganò et al. Nature Communications
- Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens
- (2014) Leigh A. Knodler et al. Cell Host & Microbe
- Radiation Exposure Induces Inflammasome Pathway Activation in Immune Cells
- (2014) Veit M. Stoecklein et al. JOURNAL OF IMMUNOLOGY
- Inflammatory caspases are innate immune receptors for intracellular LPS
- (2014) Jianjin Shi et al. NATURE
- Regulated necrosis: the expanding network of non-apoptotic cell death pathways
- (2014) Tom Vanden Berghe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Necroptotic signaling in adaptive and innate immunity
- (2014) Jennifer V. Lu et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Consensus guidelines for the detection of immunogenic cell death
- (2014) Oliver Kepp et al. OncoImmunology
- Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation
- (2013) Maria Pierdomenico et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Metabolic Regulation of T Lymphocytes
- (2013) Nancie J. MacIver et al. Annual Review of Immunology
- Preexisting antitumor immunity augments the antitumor effects of chemotherapy
- (2013) Lingbing Zhang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy
- (2013) Y. Huang et al. CANCER RESEARCH
- Targeting immunosuppression for cancer therapy
- (2013) Cristina Ghirelli et al. JOURNAL OF CLINICAL INVESTIGATION
- Immunogenic Cell Death in Cancer Therapy
- (2012) Guido Kroemer et al. Annual Review of Immunology
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Non-canonical inflammasome activation targets caspase-11
- (2011) Nobuhiko Kayagaki et al. NATURE
- T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia
- (2011) M. Kalos et al. Science Translational Medicine
- Radiofrequency Thermal Ablation for Hepatocellular Carcinoma Stimulates Autologous NK-Cell Response
- (2010) Alessandro Zerbini et al. GASTROENTEROLOGY
- The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
- (2010) Mustafa S. Ascha et al. HEPATOLOGY
- The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
- (2010) Irving C. Allen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
- (2010) M. Lamkanfi et al. JOURNAL OF IMMUNOLOGY
- Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
- (2010) B. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
- (2009) Sudan He et al. CELL
- RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
- (2009) D.-W. Zhang et al. SCIENCE
- Identification of RIP1 kinase as a specific cellular target of necrostatins
- (2008) Alexei Degterev et al. Nature Chemical Biology
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