NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection

(2013) M. T. R. Gomes et al.   JOURNAL OF IMMUNOLOGY

Evaluation of pyroptosis in macrophages using cytosolic delivery of purified flagellin

(2013) Silvia L. Lage et al.   METHODS

Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania

(2013) Djalma S Lima-Junior et al.   NATURE MEDICINE

Role of Inflammasomes in Host Defense againstCitrobacter rodentiumInfection

(2012) Zhiping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target Genes

(2012) Süheda Erener et al.   MOLECULAR CELL

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Activation of an NLRP3 Inflammasome Restricts Mycobacterium kansasii Infection

(2012) Chang-Chieh Chen et al.   PLoS One

Inhibition of poly(ADP-ribose) Polymerase Interferes with Trypanosoma cruzi Infection and Proliferation of the Parasite

(2012) Salomé C. Vilchez Larrea et al.   PLoS One

Requirement of UNC93B1 Reveals a Critical Role for TLR7 in Host Resistance to Primary Infection with Trypanosoma cruzi

(2011) B. C. Caetano et al.   JOURNAL OF IMMUNOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Control of infection by pyroptosis and autophagy: role of TLR and NLR

(2010) Karina R. Bortoluci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants

(2010) Roberto Spreafico et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease

(2010) Caroline Junqueira et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular development

(2010) L.A.G. Albertti et al.   MICROBES AND INFECTION

Chagas disease: a new worldwide challenge

(2010) José Rodrigues Coura et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chagas disease in Spain, the United States and other non-endemic countries

(2009) Joaquim Gascon et al.   ACTA TROPICA

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Listeria monocytogenes-Infected Human Peripheral Blood Mononuclear Cells Produce IL-1 , Depending on Listeriolysin O and NLRP3

(2009) K. Meixenberger et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance against Trypanosoma cruzi Infection

(2009) G. K. Silva et al.   JOURNAL OF IMMUNOLOGY

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

The effects of nitric oxide on the immune system during Trypanosoma cruzi infection

(2009) Fredy RS Gutierrez et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY