NOD Signaling and Cell Death

Trace levels of peptidoglycan in serum underlie the NOD-dependent cytokine response to endoplasmic reticulum stress

(2019) Raphael Molinaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors

(2018) Chalada Suebsuwong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

(2018) Matous Hrdinka et al.   EMBO JOURNAL

Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling

(2018) Tatiana Goncharov et al.   MOLECULAR CELL

IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans

(2018) Che A. Stafford et al.   Cell Reports

Outer Membrane Vesicles From Probiotic and Commensal Escherichia coli Activate NOD1-Mediated Immune Responses in Intestinal Epithelial Cells

(2018) María-Alexandra Cañas et al.   Frontiers in Microbiology

Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation

(2018) Madelyn H. Miller et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development

(2018) Flávia V. Santa-Cecília et al.   PAIN

CARD domain of rat RIP2 kinase: Refolding, solution structure, pH-dependent behavior and protein-protein interactions

(2018) Sergey A. Goncharuk et al.   PLoS One

RIP2 filament formation is required for NOD2 dependent NF-κB signalling

(2018) Erika Pellegrini et al.   Nature Communications

NOD1 and NOD2 in inflammation, immunity and disease

(2018) Tapas Mukherjee et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex

(2018) Swarupa Panda et al.   Nature Communications

Structural basis of RIP2 activation and signaling

(2018) Qin Gong et al.   Nature Communications

Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens

(2018) Sylvain Normand et al.   Nature Communications

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation

(2017) Erika Pellegrini et al.   PLoS One

Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases

(2017) Xiaohui He et al.   ACS Medicinal Chemistry Letters

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP

(2017) Pradeep Bist et al.   Nature Communications

Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance

(2017) Kenny L. Chan et al.   Cell Reports

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

(2016) Pamela A. Haile et al.   JOURNAL OF MEDICINAL CHEMISTRY

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

Proteogenomics connects somatic mutations to signalling in breast cancer

(2016) Philipp Mertins et al.   NATURE

NOD-Like Receptors in Infection, Immunity, and Diseases

(2016) Young Keun Kim et al.   YONSEI MEDICAL JOURNAL

Crystal structure of NOD2 and its implications in human disease

(2016) Sakiko Maekawa et al.   Nature Communications

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

(2016) Matous Hrdinka et al.   Cell Reports

Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages

(2016) Anna Lena Jung et al.   PLoS Pathogens

Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity

(2015) Adam K. Charnley et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interferon gamma boosts the nucleotide oligomerization domain 2-mediated signaling pathway in human dendritic cells in an X-linked inhibitor of apoptosis protein and mammalian target of rapamycin-dependent manner

(2015) Tünde Fekete et al.   Cellular & Molecular Immunology

Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

(2015) Peter Canning et al.   CHEMISTRY & BIOLOGY

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance

(2015) E. Denou et al.   EMBO Molecular Medicine

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

(2015) Ueli Nachbur et al.   Nature Communications

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Structural basis of death domain signaling in the p75 neurotrophin receptor

(2015) Zhi Lin et al.   eLife

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling

(2014) Aaron T. Irving et al.   Cell Host & Microbe

Fusion ofLegionella pneumophilaouter membrane vesicles with eukaryotic membrane systems is a mechanism to deliver pathogen factors to host cell membranes

(2014) Jens Jäger et al.   CELLULAR MICROBIOLOGY

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

Engagement of Nucleotide-binding Oligomerization Domain-containing Protein 1 (NOD1) by Receptor-interacting Protein 2 (RIP2) Is Insufficient for Signal Transduction

(2014) Sophie Mayle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In VivoInhibition of RIPK2 Kinase Alleviates Inflammatory Disease

(2014) Justine T. Tigno-Aranjuez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Chaperone HSP70 Binds to and Stabilizes NOD2, an Important Protein Involved in Crohn Disease

(2014) Vishnu Mohanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Genome-wide Small Interfering RNA (siRNA) Screen Reveals Nuclear Factor-κB (NF-κB)-independent Regulators of NOD2-induced Interleukin-8 (IL-8) Secretion

(2014) Neil Warner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2

(2014) N. Marina-Garcia et al.   JOURNAL OF IMMUNOLOGY

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

(2014) Stephen M. Condon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural insights into the MDP binding and CARD-CARD interaction in zebrafish (Danio rerio) NOD2: a molecular dynamics approach

(2014) Jitendra Maharana et al.   JOURNAL OF MOLECULAR RECOGNITION

NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6

(2014) T Watanabe et al.   Mucosal Immunology

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

(2014) Norihiro Nakamura et al.   NATURE

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

Disease-causing mutations in the XIAPBIR2 domain impair NOD2-dependent immune signalling

(2013) Rune Busk Damgaard et al.   EMBO Molecular Medicine

Linear ubiquitination-mediated NF- B regulation and its related disorders

(2013) F. Tokunaga   JOURNAL OF BIOCHEMISTRY

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

(2013) Berthe Katrine Fiil et al.   MOLECULAR CELL

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

(2013) Shuo Yang et al.   NATURE IMMUNOLOGY

T Cell Intrinsic NOD2 Is Dispensable for CD8 T Cell Immunity

(2013) Gloria H. Y. Lin et al.   PLoS One

Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation

(2013) J. Silke et al.   Cold Spring Harbor Perspectives in Biology

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Proteasomal Degradation of Nod2 Protein Mediates Tolerance to Bacterial Cell Wall Components

(2012) Kyoung-Hee Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment

(2012) Catherine Leimkuhler Grimes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

(2012) Rune Busk Damgaard et al.   MOLECULAR CELL

Is BID required for NOD signalling?

(2012) Ueli Nachbur et al.   NATURE

The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

(2012) Monika Schneider et al.   NATURE IMMUNOLOGY

The Tandem CARDs of NOD2: Intramolecular Interactions and Recognition of RIP2

(2012) Veronica Fridh et al.   PLoS One

Outer Membrane Vesicles from Brucella abortus Promote Bacterial Internalization by Human Monocytes and Modulate Their Innate Immune Response

(2012) Cora N. Pollak et al.   PLoS One

NOD1 Activators Link Innate Immunity to Insulin Resistance

(2011) J. D. Schertzer et al.   DIABETES

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii

(2011) Braulia C. Caetano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands

(2011) Joao G. Magalhaes et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

Discovery of Salmonella Virulence Factors Translocated via Outer Membrane Vesicles to Murine Macrophages

(2011) Hyunjin Yoon et al.   INFECTION AND IMMUNITY

Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation

(2011) Birte Zurek et al.   Innate Immunity

l-Ala-γ-d-Glu-meso-diaminopimelic Acid (DAP) Interacts Directly with Leucine-rich Region Domain of Nucleotide-binding Oligomerization Domain 1, Increasing Phosphorylation Activity of Receptor-interacting Serine/Threonine-protein Kinase 2 and Its Interaction with Nucleotide-binding Oligomerization Domain 1

(2011) Hamed Laroui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Roles for Nod2 Protein and Autocrine Interleukin-1β in Muramyl Dipeptide-induced Mitogen-activated Protein Kinase Activation and Cytokine Secretion in Human Macrophages

(2011) Matija Hedl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muramyl Dipeptide Induces Th17 Polarization through Activation of Endothelial Cells

(2011) M. Manni et al.   JOURNAL OF IMMUNOLOGY

Non-apoptotic role of BID in inflammation and innate immunity

(2011) Garabet Yeretssian et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

Nucleotide-Binding Oligomerization Domain-2 Inhibits Toll-Like Receptor-4 Signaling in the Intestinal Epithelium

(2010) Ward M. Richardson et al.   GASTROENTEROLOGY

Secretory Mediators Regulate Nod2-Induced Tolerance in Human Macrophages

(2010) Matija Hedl et al.   GASTROENTEROLOGY

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses

(2010) J. T. Tigno-Aranjuez et al.   GENES & DEVELOPMENT

Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection

(2010) Christoph Alexander Kasper et al.   IMMUNITY

Muropeptides trigger distinct activation profiles in macrophages and dendritic cells

(2010) Mikhail V. Pashenkov et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors

(2010) Terese Petterson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells

(2010) Cristina Conforti-Andreoni et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Extracellular proteins secreted by probiotic bacteria as mediators of effects that promote mucosa-bacteria interactions

(2010) B. Sanchez et al.   MICROBIOLOGY-SGM

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Defining the conserved internal architecture of a protein kinase

(2009) Alexandr P. Kornev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The distinct response of γδ T cells to the Nod2 agonist muramyl dipeptide

(2009) Hannah M.M. Kerns et al.   CELLULAR IMMUNOLOGY

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

(2009) Maria Kaparakis et al.   CELLULAR MICROBIOLOGY

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

(2009) MingFang Tao et al.   CURRENT BIOLOGY

Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan

(2009) Chung-Hang Leung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

(2009) Mathieu J.M. Bertrand et al.   IMMUNITY

Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease

(2009) Tian-Tian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

pH-dependent Internalization of Muramyl Peptides from Early Endosomes Enables Nod1 and Nod2 Signaling

(2009) Jooeun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Kinase Activity of Rip2 Determines Its Stability and Consequently Nod1- and Nod2-mediated Immune Responses

(2009) Chiara Nembrini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clathrin- and Dynamin-Dependent Endocytic Pathway Regulates Muramyl Dipeptide Internalization and NOD2 Activation

(2009) N. Marina-Garcia et al.   JOURNAL OF IMMUNOLOGY

Large-scale Proteomics Analysis of the Human Kinome

(2009) Felix S. Oppermann et al.   MOLECULAR & CELLULAR PROTEOMICS

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

XIAP mediates NOD signaling via interaction with RIP2

(2009) A. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

(2008) Osamu Hitotsumatsu et al.   IMMUNITY

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis

(2008) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle

(2008) Henrik Daub et al.   MOLECULAR CELL

The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences

(2008) Martina Proell et al.   PLoS One

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival

(2008) Sheena M Cruickshank et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Engagement of NOD2 has a dual effect on proIL-1β mRNA transcription and secretion of bioactive IL-1β

(2007) Gerben Ferwerda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY