Role of inflammasomes/pyroptosis and PANoptosis during fungal infection

β-Glucan–induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies

(2020) Giorgio Camilli et al.   JOURNAL OF CLINICAL INVESTIGATION

Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae

(2019) Ona Rogiers et al.   mBio

CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

(2019) Rebecca A. Drummond et al.   NATURE IMMUNOLOGY

Candidalysin: discovery and function in Candida albicans infections

(2019) Julian R Naglik et al.   CURRENT OPINION IN MICROBIOLOGY

Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection

(2018) Timothy M. Tucey et al.   Cell Metabolism

IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection

(2018) Teneema Kuriakose et al.   JOURNAL OF IMMUNOLOGY

Penetration of the Human Pulmonary Epithelium by Aspergillus fumigatus Hyphae

(2018) Julien Fernandes et al.   JOURNAL OF INFECTIOUS DISEASES

Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1β in Aspergillus fumigatus Infection

(2018) Yan Sun et al.   JOURNAL OF IMMUNOLOGY

A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

(2018) Kristy Koselny et al.   mBio

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

(2018) Lydia Kasper et al.   Nature Communications

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection

(2018) Benoit Briard et al.   Nature Microbiology

Differential roles of caspase-1 and caspase-11 in infection and inflammation

(2017) Si Ming Man et al.   Scientific Reports

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

Galactosaminogalactan of Aspergillus fumigatus, a bioactive fungal polymer

(2016) Benoit Briard et al.   MYCOLOGIA

Candidalysin is a fungal peptide toxin critical for mucosal infection

(2016) David L. Moyes et al.   NATURE

Inflammasome-Independent Regulation of IL-1-Family Cytokines

(2015) Mihai G. Netea et al.   Annual Review of Immunology

Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra

(2015) Monica Borghi et al.   Cell Host & Microbe

Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

(2015) Rajendra Karki et al.   Cell Host & Microbe

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

The interplay between inflammasome activation and antifungal host defense

(2015) Frank L. van de Veerdonk et al.   IMMUNOLOGICAL REVIEWS

Induction of Caspase-11 by Aspartyl Proteinases of Candida albicans and Implication in Promoting Inflammatory Response

(2015) Elena Gabrielli et al.   INFECTION AND IMMUNITY

InternalizedCryptococcus neoformansActivates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes

(2015) Mingkuan Chen et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System

(2015) Rebecca A. Drummond et al.   PLoS Pathogens

Malasseziayeasts activate the NLRP3 inflammasome in antigen-presenting cells via Syk-kinase signalling

(2014) Magdalena Kistowska et al.   EXPERIMENTAL DERMATOLOGY

The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency

(2014) Stuart E. Turvey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen,Candida albicans

(2014) Sandhya Ganesan et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome

(2014) Caiqin Guo et al.   MICROBES AND INFECTION

IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis

(2014) Silvia Moretti et al.   PLoS Pathogens

A Polysaccharide Virulence Factor from Aspergillus fumigatus Elicits Anti-inflammatory Effects through Induction of Interleukin-1 Receptor Antagonist

(2014) Mark S. Gresnigt et al.   PLoS Pathogens

Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages

(2013) Melanie Wellington et al.   EUKARYOTIC CELL

Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome

(2013) Liming Mao et al.   INFECTION AND IMMUNITY

NLRP3 Inflammasome Activation by Paracoccidioides brasiliensis

(2013) Aldo Henrique Tavares et al.   PLoS Neglected Tropical Diseases

Secreted aspartic proteases ofCandida albicansactivate the NLRP3 inflammasome

(2012) Donatella Pietrella et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis

(2011) Frank L. van de Veerdonk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

(2011) Shih-Chin Cheng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Novel Role for the NLRC4 Inflammasome in Mucosal Defenses against the Fungal Pathogen Candida albicans

(2011) Jeffrey Tomalka et al.   PLoS Pathogens

The Inflammatory Response Induced by Aspartic Proteases of Candida albicans Is Independent of Proteolytic Activity

(2010) D. Pietrella et al.   INFECTION AND IMMUNITY

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal  -Glucan

(2009) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

(2009) S. Joly et al.   JOURNAL OF IMMUNOLOGY

Bypassing Pathogen‐Induced Inflammasome Activation for the Regulation of Interleukin‐1β Production by the Fungal PathogenCandida albicans

(2009) Frank L. van de Veerdonk et al.   JOURNAL OF INFECTIOUS DISEASES

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE