NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8+ T lymphocytes

The Journey from Discoveries in Fundamental Immunology to Cancer Immunotherapy

(2015) Jacques F.A.P. Miller et al.   CANCER CELL

NLRC5 Exclusively Transactivates MHC Class I and Related Genes through a Distinctive SXY Module

(2015) Kristina Ludigs et al.   PLoS Genetics

MHC Class I Antigen Processing and Presenting Machinery: Organization, Function, and Defects in Tumor Cells

(2013) P. Leone et al.   JNCI-Journal of the National Cancer Institute

Immunotherapy-induced CD8+ T Cells Instigate Immune Suppression in the Tumor

(2013) A J Robert McGray et al.   MOLECULAR THERAPY

Harnessing the Power of the Immune System to Target Cancer

(2012) Gregory Lizée et al.   Annual Review of Medicine

The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity

(2012) Torsten B. Meissner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens

(2012) Yikun Yao et al.   CELL RESEARCH

Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice

(2012) Yanzheng Tong et al.   CELL RESEARCH

Regulation of Class I Major Histocompatibility Complex (MHC) by Nucleotide-binding Domain, Leucine-rich Repeat-containing (NLR) Proteins

(2012) Gregory R. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRC5 Controls Basal MHC Class I Gene Expression in an MHC Enhanceosome-Dependent Manner

(2012) A. Neerincx et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells

(2012) F. Staehli et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5/Class I Transactivator

(2012) A. Biswas et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Cooperates with the RFX Transcription Factor Complex To Induce MHC Class I Gene Expression

(2012) T. B. Meissner et al.   JOURNAL OF IMMUNOLOGY

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

Expression of tumour-specific antigens underlies cancer immunoediting

(2012) Michel DuPage et al.   NATURE

The role of classical and non-classical HLA class I antigens in human tumors

(2012) Juergen Bukur et al.   SEMINARS IN CANCER BIOLOGY

Novel insights into the molecular mechanisms of HLA class I abnormalities

(2011) Barbara Seliger   CANCER IMMUNOLOGY IMMUNOTHERAPY

Association of IFN-  Signal Transduction Defects with Impaired HLA Class I Antigen Processing in Melanoma Cell Lines

(2011) A. Respa et al.   CLINICAL CANCER RESEARCH

Strategies to counteract MHC-I defects in tumors

(2011) Margit H Lampen et al.   CURRENT OPINION IN IMMUNOLOGY

Exposure to IL-15 and IL-21 Enables Autoreactive CD8 T Cells To Respond to Weak Antigens and Cause Disease in a Mouse Model of Autoimmune Diabetes

(2011) S. Ramanathan et al.   JOURNAL OF IMMUNOLOGY

Cross-dressers turn on T cells

(2011) Jonathan W. Yewdell et al.   NATURE

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

(2010) Jun Cui et al.   CELL

“Hard” and “soft” lesions underlying the HLA class I alterations in cancer cells: Implications for immunotherapy

(2010) Federico Garrido et al.   INTERNATIONAL JOURNAL OF CANCER

A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses

(2010) Andreas Neerincx et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRC5 Limits the Activation of Inflammatory Pathways

(2010) S. Benko et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NLRC5-Dependent Activation of the Inflammasome

(2010) B. K. Davis et al.   JOURNAL OF IMMUNOLOGY

The Nucleotide-Binding Oligomerization Domain-Like Receptor NLRC5 Is Involved in IFN-Dependent Antiviral Immune Responses

(2010) Sven Kuenzel et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections

(2010) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of MHC class I abnormalities and APM components in human tumors

(2008) Barbara Seliger   CANCER IMMUNOLOGY IMMUNOTHERAPY

Analysis of HLA class I expression in progressing and regressing metastatic melanoma lesions after immunotherapy

(2008) Rafael Carretero et al.   IMMUNOGENETICS

HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance

(2008) M Campoli et al.   ONCOGENE