Article
Medicine, Research & Experimental
Chi Zhang, Junsheng Wang, Xiaohui Xie, Dong Sun
Summary: This study found that PD patients have lower 25(OH)D concentrations, which are correlated with anemia, oxidative stress, and microinflammation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Urology & Nephrology
Bruno Legendre, Thierry Lobbedez, Cecile Couchoud, Mathilde Lassalle, Isabelle Kazes, Antoine Lanot, Annabel Boyer, Clemence Bechade
Summary: The duration of hemodialysis before transfer to peritoneal dialysis affects the outcomes and survival of patients on peritoneal dialysis.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Jennifer M. Kaplan, Jingbo Niu, Vivian Ho, Wolfgang C. Winkelmayer, Kevin F. Erickson
Summary: The study shows that for patients over 67 years old, peritoneal dialysis (PD) has a significant advantage over in-center hemodialysis in terms of Medicare expenditures, although there is no significant difference in the dialysis modality. Over time, the gap in dialysis expenditures gradually narrowed, while the gap in nondialysis expenditures widened.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Joaquim Barreto, Cynthia Borges, Tais Betoni Rodrigues, Daniel C. Jesus, Alessandra M. Campos-Staffico, Wilson Nadruz, Jose Luiz da Costa, Rodrigo Bueno de Oliveira, Andrei C. Sposito
Summary: The study aimed to evaluate the effects of SGLT2 inhibitors on cardiovascular outcomes in patients with conservatively managed CKD. It was found that dapagliflozin was well tolerated and had nonaccumulating pharmacokinetic properties in patients with kidney failure on dialysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Annie-Claire Nadeau-Fredette, Nidhi Sukul, Mark Lambie, Jeffrey Perl, Simon Davies, David W. Johnson, Bruce Robinson, Wim Van Biesen, Anneke Kramer, Kitty J. Jager, Rajiv Saran, Ronald Pisoni, Christopher T. Chan
Summary: This multinational study found that mortality rates were highest in the first month after transitioning from peritoneal dialysis to hemodialysis, and gradually declined afterwards. Older age, earlier initiation of peritoneal dialysis, and longer peritoneal dialysis duration were associated with increased risk of death.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Qianying Zhang, Pei Wu, Jingyuan Xie, Xiao Li, Tian Xu, Xiaomin Huang, Chunyan Zhang, Nan Chen, Hong Ren
Summary: The use of automated peritoneal dialysis (APD) may be more favorable than hemodialysis (HD) for protecting residual renal function when initiating peritoneal dialysis. Both methods have similar rates of mechanical and infectious complications.
Article
Economics
Eugene Lin, Khristina Lung, Glenn M. Chertow, Jay Bhattacharya, Darius Lakdawalla
Summary: In a study comparing PD and HD among uninsured patients, starting PD later in the month was associated with increased PD uptake. However, no significant differences were observed in mortality, hospitalization rates, or Medicare spending between PD and HD within the first 12 months of treatment.
Article
Medicine, General & Internal
Ming-Hsien Tsai, Yun-Yi Chen, Tsrang-Neng Jang, Jing-Tong Wang, Yu-Wei Fang
Summary: This study evaluated the clinical outcomes of patients transitioning from peritoneal dialysis (PD) to hemodialysis (HD) compared to HD-only patients. The findings showed that patients transitioning from PD had a higher risk of all-cause death, especially in the first 5 months after transition.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Emily Blaine, Robin Tumlinson, Marion Colvin, Tyler Haynes, Heather P. Whitley
Summary: Chronically uncontrolled hyperglycemia is a common factor in end stage kidney disease (ESKD) that requires dialysis. However, there is a lack of clear clinical recommendations for adjusting insulin dosing during the transition to hemodialysis (HD) or peritoneal dialysis (PD).
Article
Transplantation
Melis Sahinoz, Supisara Tintara, Serpil Muge Deger, Aseel Alsouqi, Rachelle L. Crescenzi, Cindy Mambungu, Andrew Vincz, Olivia Mason, Heather L. Prigmore, Andrew Guide, Thomas G. Stewart, David Harrison, Friedrich C. Luft, Jens Titze, T. Alp Ikizler
Summary: The study revealed that dialysis patients have higher muscle and skin Na+ accumulation compared to controls. Different ethnicities among dialysis patients may have varying levels of muscle and skin Na+. Systemic inflammation is correlated with increased muscle and skin Na+ content in dialysis patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Miho Murashima, Takayuki Hamano, Masanori Abe, Ikuto Masakane
Summary: This study found that the combination therapy of PD and once-weekly hemodialysis is associated with lower infection-related mortality but not with a lower incidence of EPS in the short term. Patients on combination therapy had a decreasing D/P Cr ratio over time, while those on PD alone had an increasing ratio.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Yi-Chun Wang, Shu-Hui Juan, Ching-Hao Li, Chu-Lin Chou, Li-Ying Chen, Li-Nien Chien, Te-Chao Fang
Summary: This population-based study examines the risk of valacyclovir-associated neurotoxicity (VAN) in patients with end-stage renal disease (ESRD) on dialysis. The study finds that valacyclovir users in the ESRD cohort have a higher risk of altered mental status compared to non-users, especially in patients on hemodialysis (HD) or peritoneal dialysis (PD). Adjusting the valacyclovir dosage and monitoring VAN is crucial in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wiktoria Grycuk, Zuzanna Jakubowska, Jolanta Malyszko
Summary: Recent study discovered that proenkephalin A (PENK A) does not reflect renal function and cardiac status in patients with end-stage kidney disease (ESKD). Further research is required to establish the clinical utility of this new biomarker in patients with impaired kidney function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Cheng Han Ng, Zhi Hao Ong, Hersharan Kaur Sran, Teo Boon Wee
Summary: A meta-analysis was conducted to summarize the prevalence of cardiovascular disease events in dialysis patients, revealing that atrial fibrillation, congestive heart failure, and peripheral arterial disease were more common in hemodialysis patients, while cardiovascular mortality was lower. Further research is needed to establish causality between dialysis modality and cardiovascular outcomes.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Valentina Masola, Mario Bonomini, Silvio Borrelli, Lorenzo Di Liberato, Luigi Vecchi, Maurizio Onisto, Giovanni Gambaro, Roberto Palumbo, Arduino Arduini
Summary: Peritoneal dialysis is an efficient renal replacement therapy, but long-term use can lead to peritoneal fibrosis. The development of fibrosis is mainly due to the bio-incompatibility of PD solution, so it is necessary to develop more biocompatible PD solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Transplantation
Giovanni Gambaro, Lazaros Tzelves, Andreas Skolarikos, Mehmet Kanbay, Alberto Ortiz, Mario Cozzolino
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Food Science & Technology
Gianvito Caggiano, Alessandra Stasi, Rossana Franzin, Marco Fiorentino, Maria Teresa Cimmarusti, Annamaria Deleonardis, Rita Palieri, Paola Pontrelli, Loreto Gesualdo
Summary: The gut microbiome plays a crucial role in kidney disease, with dysbiosis-related uremic toxins and pro-inflammatory mediators contributing to kidney function deterioration. The toxicity of uremic compounds has been well-documented in various pathophysiological mechanisms, such as cardiovascular injury, metabolic dysfunction, and inflammation. Accumulating evidence supports the use of fecal microbiota transplantation (FMT) as a promising treatment to reduce uremic toxin accumulation. This review presents the current state of FMT application in kidney disease to restore a healthy microbiome and reverse uremic toxin retention.
Article
Biochemistry & Molecular Biology
Gianvito Caggiano, Loredana Amodio, Alessandra Stasi, Nicola Antonio Colabufo, Santina Colangiulo, Francesco Pesce, Loreto Gesualdo
Summary: In recent years, indoxyl sulfate has been found to play a significant role in the progression of kidney disease and the development of cardiovascular problems. However, current methods for measuring indoxyl sulfate levels, such as LC-MS/MS, are time-consuming and require specialized equipment. In this pilot study, we developed a fast and simple alternative method using colorimetric assay to accurately measure indoxyl sulfate levels in serum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Fabio Sallustio, Angela Picerno, Francesca Montenegro, Maria Teresa Cimmarusti, Vincenzo Di Leo, Loreto Gesualdo
Summary: The human virome, consisting of prokaryotes, viruses, fungi, and parasites, is intricately connected with the human host. Different viral community states have been identified as indicators of health or undesirable outcomes for the host. The virome can collaborate with the human host in maintaining mutualistic functions and preserving human health. This Review explores the role of viruses in health and disease, the relationship between the virobiota and immune system control, and the potential molecular mechanisms linking viruses to glomerulonephritis and IgA nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Davide Fiore Bavaro, Lucia Diella, Alessandra Belati, Giuliana Metrangolo, Laura De Santis, Vito Spada, Michele Camporeale, Angelo Dargenio, Gaetano Brindicci, Flavia Balena, Deborah Fiordelisi, Fabio Signorile, Giacomo Loseto, Crescenza Pasciolla, Carla Minoia, Immacolata Attolico, Tommasina Perrone, Simona Simone, Maria Rendina, Nicoletta Giovine, Francesco Di Gennaro, Pellegrino Musto, Attilio Guarini, Alfredo Di Leo, Loreto Gesualdo, Maria Dell'Aera, Annalisa Saracino
Summary: Remdesivir (REM) and monoclonal antibodies (mAbs) may alleviate severe COVID-19 in at-risk hospitalized patients, particularly in elderly or immunocompromised hosts. The use of REM and mAbs was associated with a reduced risk of severe COVID-19, and the combination therapy was particularly beneficial for immunocompromised patients.
Review
Cell Biology
Francesca Giannuzzi, Silvia Maiullari, Loreto Gesualdo, Fabio Sallustio
Summary: Long non-coding RNAs (lncRNAs) are a diverse group of transcripts that regulate gene expression at different levels in various cellular contexts and biological processes. Understanding their mechanisms of action and their involvement in disease can lead to potential therapeutic approaches. In the context of renal pathogenesis, the role of lncRNAs is still not well understood, particularly in healthy kidneys and adult renal stem/progenitor cells (ARPC). This review provides an overview of lncRNA biogenesis, degradation, and functions, focusing on their functional roles in kidney diseases and their regulation of stem cell biology, with a specific emphasis on the lncRNA HOTAIR's ability to prevent senescence in ARPC.
Article
Cell Biology
Rossana Franzin, Alessandra Stasi, Giuseppe De Palma, Angela Picerno, Claudia Curci, Serena Sebastiano, Monica Campioni, Antonella Cicirelli, Alessandro Rizzo, Vito Francesco Di Lorenzo, Paola Pontrelli, Giovanni Battista Pertosa, Giuseppe Castellano, Loreto Gesualdo, Fabio Sallustio
Summary: In this study, it was found that tubular adult renal progenitor cells (tARPC) can influence the gene expression of renal proximal tubular cell (RPTEC) during cisplatin-induced nephrotoxicity via the release of extracellular vesicles (EV) enriched with CYP1B1 and miR-27b-3p. CYP1B1 expression was correlated with renal function.
Review
Biochemistry & Molecular Biology
Marco Fiorentino, Francesca Bagagli, Annamaria Deleonardis, Alessandra Stasi, Rossana Franzin, Francesca Conserva, Barbara Infante, Giovanni Stallone, Paola Pontrelli, Loreto Gesualdo
Summary: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD). Kidney transplant recipients (KTRs) are at a higher risk of ICU admission, mainly in the late post-transplant period. Urosepsis and bloodstream infections are the main reasons for ICU admissions, and side effects of immunosuppressive treatment should also be accounted for. AKI incidence is common in KTRs during ICU stay, and in-hospital mortality can be high. The present review aims to explore the impact of AKI on outcomes in KTRs and provide insights into its diagnosis, management, and immunosuppression modulation.
Article
Urology & Nephrology
Simona Simone, Francesco Pesce, Giulia Fonto, Virginia Pronzo, Paola Pontrelli, Francesca Conserva, Annalisa Schirinzi, Annalisa Casanova, Pasquale Gallo, Michele Rossini, Giuseppe Lucarelli, Marco Spilotros, Maria Rendina, Giovanni Stallone, Francesca Di Serio, Alfredo Di Leo, Silvio Tafuri, Pasquale Ditonno, Loreto Gesualdo
Summary: This study aimed to evaluate the seroconversion rate after BNT162b2 vaccine in kidney transplant recipients, factors associated with humoral response, and clinical outcome of COVID-19 in these patients. The results showed that after three doses of the vaccine, kidney transplant patients exhibited a late but effective immune response against SARS-CoV-2, reducing morbidity and mortality.
JOURNAL OF NEPHROLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Nicola Altini, Michele Rossini, Sandor Turkevi-Nagy, Francesco Pesce, Paola Pontrelli, Berardino Prencipe, Francesco Berloco, Surya Seshan, Jean-Baptiste Gibier, Anibal Pedraza Dorado, Gloria Bueno, Licia Peruzzi, Mattia Rossi, Albino Eccher, Feifei Li, Adamantios Koumpis, Oya Beyan, Jonathan Barratt, Huy Quoc Vo, Chandra Mohan, Hien Van Nguyen, Pietro Antonio Cicalese, Angela Ernst, Loreto Gesualdo, Vitoantonio Bevilacqua, Jan Ulrich Becker
Summary: The study aimed to replicate the glomerular components of the Oxford Classification for IgA nephropathy using a deep learning pipeline. The results showed excellent performance in automatic glomerular segmentation and classification, with high correlation to expert labels, meeting the requirements of the Oxford Classification.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
