Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis

(2016) Marjolein Garsen et al.   AMERICAN JOURNAL OF PATHOLOGY

Vascular Growth Factors and Glomerular Disease

(2016) Christina S. Bartlett et al.   Annual Review of Physiology

Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy

(2016) Margien G.S. Boels et al.   DIABETES

Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx

(2016) M. Garsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cathepsin L is crucial for the development of early experimental diabetic nephropathy

(2016) Marjolein Garsen et al.   KIDNEY INTERNATIONAL

Autophagy in kidney disease and aging: lessons from rodent models

(2016) Olivia Lenoir et al.   KIDNEY INTERNATIONAL

Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria

(2016) Marjolein Garsen et al.   PLoS One

Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis

(2016) Marina Weissmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury

(2016) Valentina Masola et al.   PLoS One

Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy

(2015) Anna Shteingauz et al.   CANCER RESEARCH

Modulation of the binding of basic fibroblast growth factor and heparanase activity by purified λ-carrageenan oligosaccharides

(2015) Ting-Ting Niu et al.   CARBOHYDRATE POLYMERS

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

(2015) Bart Roucourt et al.   CELL RESEARCH

The cell biology of renal filtration

(2015) Rizaldy P. Scott et al.   JOURNAL OF CELL BIOLOGY

Vitamin D attenuates proteinuria by inhibition of heparanase expression in the podocyte

(2015) Marjolein Garsen et al.   JOURNAL OF PATHOLOGY

Perlecan inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle

(2015) Liang Ning et al.   MATRIX BIOLOGY

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

The glycocalyx—linking albuminuria with renal and cardiovascular disease

(2015) Ton J. Rabelink et al.   Nature Reviews Nephrology

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial

(2015) Dick de Zeeuw et al.   Lancet Diabetes & Endocrinology

Pharmacological Inhibition of DNA Methylation Induces Proinvasive and Prometastatic Genes In Vitro and In Vivo

(2015) Bushra Ateeq et al.   NEOPLASIA

Induction of Heparanase-1 Expression by Mutant B-Raf Kinase: Role of GA Binding Protein in Heparanase-1 Promoter Activation

(2015) Geetha Rao et al.   NEOPLASIA

Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium

(2014) Rebecca Lever et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin

(2014) Anna Shteingauz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of Heparanase-Driven Inflammatory Cascade in Pathogenesis of Diabetic Nephropathy

(2014) R. Goldberg et al.   DIABETES

Shed Syndecan-1 Translocates to the Nucleus of Cells Delivering Growth Factors and Inhibiting Histone Acetylation

(2014) Mark D. Stewart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Containing Unsubstituted Glucosamine Residues

(2014) Satomi Nadanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis

(2014) Angelique LWMM Rops et al.   KIDNEY INTERNATIONAL

The Protective Role of Fucosylated Chondroitin Sulfate, a Distinct Glycosaminoglycan, in a Murine Model of Streptozotocin-Induced Diabetic Nephropathy

(2014) Conrado L. R. Gomes et al.   PLoS One

Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4

(2014) Katharine J. Goodall et al.   PLoS One

1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase

(2013) Jennifer C. Wilson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heparanase in inflammation and inflammation-associated cancer

(2013) Amichay Meirovitz et al.   FEBS Journal

 -Arrestin-1 Drives Endothelin-1-Mediated Podocyte Activation and Sustains Renal Injury

(2013) S. Buelli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Multi-faceted substrate specificity of heparanase

(2013) Sherket B. Peterson et al.   MATRIX BIOLOGY

Heparan sulfate in the nucleus and its control of cellular functions

(2013) Mark D. Stewart et al.   MATRIX BIOLOGY

Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues

(2013) Edward Hammond et al.   FEBS Open Bio

Heparanase and Autoimmune Diabetes

(2013) Charmaine J. Simeonovic et al.   Frontiers in Immunology

Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression

(2012) Miry Blich et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation

(2012) T. V. Brennan et al.   BLOOD

Endothelial Heparan Sulfate 6-O-Sulfation Levels Regulate Angiogenic Responses of Endothelial Cells to Fibroblast Growth Factor 2 and Vascular Endothelial Growth Factor

(2012) Cristina Ferreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Urine Heparanase Levels Are Associated with Proteinuria and Decreased Renal Allograft Function

(2012) Itay Shafat et al.   PLoS One

Sulodexide for Kidney Protection in Type 2 Diabetes Patients With Microalbuminuria: A Randomized Controlled Trial

(2011) Edmund J. Lewis et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Fatty Acid-Induced Nuclear Translocation of Heparanase Uncouples Glucose Metabolism in Endothelial Cells

(2011) Fang Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

(2011) N. Gil et al.   DIABETES

Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis

(2011) G. Rao et al.   DIABETOLOGIA

Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-d-glucuronidase (heparanase)

(2011) Neha S Gandhi et al.   GLYCOBIOLOGY

Heparanase and Syndecan-1 Interplay Orchestrates Fibroblast Growth Factor-2-induced Epithelial-Mesenchymal Transition in Renal Tubular Cells

(2011) Valentina Masola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype

(2011) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival

(2011) Suma Yaddanapudi et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

(2011) Immanuel Lerner et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes

(2011) Andrew F. Ziolkowski et al.   JOURNAL OF CLINICAL INVESTIGATION

Sulodexide Fails to Demonstrate Renoprotection in Overt Type 2 Diabetic Nephropathy

(2011) D. K. Packham et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Urinary heparanase activity in patients with Type 1 and Type 2 diabetes

(2011) Angelique L.W.M.M. Rops et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and combined therapy in patients with micro- and macroalbuminuria and other cardiovascular risk factors: a systematic review of randomized controlled trials

(2011) A. Maione et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Heparanase Levels Are Elevated in the Urine and Plasma of Type 2 Diabetes Patients and Associate with Blood Glucose Levels

(2011) Itay Shafat et al.   PLoS One

Anti-Proteinuric Effect of Sulodexide in Immunoglobulin A Nephropathy

(2011) Kitae Bang et al.   YONSEI MEDICAL JOURNAL

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus

(2010) L. N. Broekhuizen et al.   DIABETOLOGIA

Heparanase 2 Interacts with Heparan Sulfate with High Affinity and Inhibits Heparanase Activity

(2010) Flonia Levy-Adam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase in primary human osteoblasts

(2010) Paul N. Smith et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial

(2010) Dick de Zeeuw et al.   LANCET

Vitamin D, Proteinuria, Diabetic Nephropathy, and Progression of CKD

(2009) R. Agarwal   Clinical Journal of the American Society of Nephrology

Abnormal Angiogenesis in Diabetic Nephropathy

(2009) T. Nakagawa et al.   DIABETES

Proteinuria: an enzymatic disease of the podocyte?

(2009) Peter Mundel et al.   KIDNEY INTERNATIONAL

Regulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species

(2009) M. J. van den Hoven et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Heparanase prevents the development of type 1 diabetes in non‐obese diabetic mice by regulating T‐cell activation and cytokines production

(2008) Menachem Bitan et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Inhibition of histone acetyltransferase by glycosaminoglycans

(2008) Jo Ann Buczek-Thomas et al.   JOURNAL OF CELLULAR BIOCHEMISTRY