Article
Biochemistry & Molecular Biology
Charbel A. Basset, Francesca Rappa, Rosario Barone, Ada Maria Florena, Rossana Porcasi, Everly Conway de Macario, Alberto J. L. Macario, Angelo Leone
Summary: Salivary gland tumors are a significant medical issue and new methods for diagnosis and treatment are needed. Molecular chaperones, particularly Hsp10 and Hsp90, show potential as biomarkers and targets for therapy. Recent research suggests that the quantity and localization patterns of Hsp90 in tissue can differentiate between benign and malignant tumors. The Hsp90 inhibitor Ganetespib exhibits cytotoxic effects on salivary gland tumors and may be a promising candidate for future treatment experimentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Jiangfeng Wu, Zhijuan Zhou, Xiaoyun Wang, Yun Jin, Zhengping Wang, Guilong Jin
Summary: This meta-analysis aimed to evaluate the effect of elastosonography for the diagnosis of salivary gland tumors and to compare it with conventional ultrasound. The results showed that elastosonography had limited value in diagnosing malignant salivary gland tumors, with a sensitivity of 0.73 and specificity of 0.64. Conventional ultrasound had a higher specificity of 0.93. Elastosonography could be considered as a supplementary diagnostic technology to conventional ultrasound, and quantitative or semiquantitative elastosonography was superior to qualitative elastosonography.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Hanno M. Witte, Niklas Gebauer, Konrad Steinestel
Summary: Salivary gland carcinomas are rare and difficult to treat. New therapeutic approaches, such as molecularly targeted therapy and immune checkpoint inhibition, are needed. Comprehensive analysis of the genomic landscape and tumor microenvironment is crucial for optimizing and personalizing treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Medicine, General & Internal
Fonthip Laohavisudhi, Titikorn Chunchai, Natnicha Ketchaikosol, Wacharaporn Thosaporn, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This study found that CD44s, CD44v6, CXCR2, and IL-113 were expressed at higher levels in salivary gland tumors, with IL-113 potentially playing a crucial role in the aggressiveness of these tumors.
Editorial Material
Oncology
Valentina Terenzi, Salvatore Martellucci, Fiorenza Dal Cortivo, Andrea Stolfa, Francesco Fiorentino, Veronica Clemenzi, Andrea Gallo, Valentino Valentini, Giulio Pagliuca
Summary: Malignant proliferating trichilemmal tumor (MPTT) is a rare tumor that occurs mainly in sun-exposed areas such as the face, scalp, neck, and dorsal part of the hand. Differential diagnosis from other skin cancers, such as squamous cell carcinoma, basal-cell carcinoma, keratoacanthoma, and malignant nodular melanoma, can only be made through incisional biopsy. We report a case of MPTT misdiagnosed as a malignant tumor of the parotid gland, which was treated with radical surgical excision and adjuvant radiotherapy.
Article
Pharmacology & Pharmacy
Lygia Sega Nogueira, Carolina P. Vasconcelos, Jessica Rodrigues Placa, Geovanni Pereira Mitre, Leonardo Oliveira Bittencourt, Maria Sueli da Silva Kataoka, Edivaldo H. C. de Oliveira, Rafael Rodrigues Lima
Summary: The study aims to investigate the gene expression changes in human salivary gland cells after exposure to MeHg through transcriptome analysis. The results showed that MeHg altered the expression of 155 genes, with upregulated genes mainly related to cell-cycle progression, DNA repair, and GSH basal metabolism, while downregulated genes were associated with impaired cell metabolism.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Haoran Zhao, Weijie Zhang, Xiaowei Tang, Edgar A. Galan, Yinheng Zhu, Gan Sang, Davit Khutsishvili, Honghui Zheng, Shaohua Ma
Summary: Tumor spread is a leading cause of cancer-related deaths, and improving the accuracy of cancer prognosis is crucial for reducing mortality rates. A study found that the electrostatic potential difference between tumors and adjacent tissues can serve as a prognostic marker for tumor spread. The enrichment of cancer stem cells in tissues with lower electrostatic potentials suggests that galvanotaxis of cancer stem cells towards lower potentials contributes to tumor spread. These findings were validated in breast and lung spheroid models. This research may inspire the development of diagnostic and prognostic strategies targeting tissue EPDs and cancer stem cells for tumor therapy.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Elisabeth Zechendorf, Katharina Schroeder, Lara Stiehler, Nadine Frank, Christian Beckers, Sandra Kraemer, Michael Dreher, Alexander Kersten, Christoph Thiemermann, Gernot Marx, Tim-Philipp Simon, Lukas Martin
Summary: Heparanase activity and heparan sulfate levels correlate with the severity and outcomes of COVID-19, and may be helpful in predicting clinical progression and outcomes in patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Koji Takumi, Hiroaki Nagano, Hidehiko Kikuno, Yuichi Kumagae, Yoshihiko Fukukura, Takashi Yoshiura
Summary: The study investigated the use of multiparametric non-contrast MR imaging to differentiate malignant from benign salivary gland lesions, finding that combining ADC, TBF, and APTSI can significantly improve diagnostic accuracy for malignant lesions compared to individual parameters.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Angang Ding, Huan Lv, Jinye Cao, Xin Wang, Ping Xiong
Summary: This study aimed to characterize the ultrasound features of cystic components in salivary gland tumors (SGTs) and found significant differences in ultrasound performance between benign SGTs (B-SGTs) and malignant SGTs (M-SGTs) with cystic components. Cystic components are of interest in the differential diagnosis of B-SGT and M-SGT using ultrasound.
Review
Pathology
Ahmed I. Abulsoud, Shereen Saeid Elshaer, Ahmed A. El-Husseiny, Doaa Fathi, Nourhan M. Abdelmaksoud, Sherif S. Abdel Mageed, Aya Salman, Mohamed Bakr Zaki, Hesham A. El-Mahdy, Ahmed Ismail, Elsayed G. E. Elsakka, Mai A. Abd-Elmawla, Hussein M. El-Husseiny, Wael S. Ibrahim, Ahmed S. Doghish
Summary: This article discusses the heterogeneity and aggressiveness of salivary gland cancer (SGC) and introduces the potential of a diagnostic and prognostic detection method based on miRs. As prognostic biomarkers and therapeutic targets, miRs can regulate the expression of genes involved in SGC. Many miRs may play a role in the development of SGC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Joseph Lopez, Yu Han Chen, Alana Eagan, Conall Fitzgerald, Robbie Woods, Richard Wong, Jatin Shah, Ian Ganly
Summary: This study aimed to investigate the occurrence, clinicopathologic behavior, management, and outcome of pediatric patients with salivary gland malignancies. The findings showed that pediatric SG malignancies are rare and have a favorable outcome at 5 years.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Immunology
Geoffrey Urbanski, Floris Chabrun, Estelle Delattre, Carole Lacout, Brittany Davidson, Odile Blanchet, Juan Manuel Chao de la Barca, Gilles Simard, Christian Lavigne, Pascal Reynier
Summary: This study aimed to find early biomarkers of primary Sjogren's syndrome in labial salivary gland using metabolomics and machine-learning approaches. A discriminant signature composed of six metabolites, including the immune-metabolite kynurenine and five phospholipids, accurately predicted primary Sjogren's syndrome status. These findings demonstrate the potential of an immuno-lipidomic signature in labial salivary gland as an accurate diagnostic tool for early primary Sjogren's syndrome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Nora Katabi, Purvil Sukhadia, Sara E. Dinapoli, Ilan Weinreb, Elan Hahn, Ronald Ghossein, Bin Xu
Summary: Salivary gland neoplasms with HMGA2::WIF1 fusion exhibit histological and immunohistochemical features similar to CAA, and these tumors are not always benign, with approximately 20% showing malignancy.
Article
Medicine, Research & Experimental
Shuting Cao, Yu-Wen Hung, Yi-Chang Wang, Yiyin Chung, Yue Qi, Ching Ouyang, Xiancai Zhong, Weidong Hu, Alaysia Coblentz, Ellie Maghami, Zuoming Sun, H. Helen Lin, David K. Ann
Summary: Attenuated host autophagy plays a role in inducing tumor rejection through reinforced adaptive immunity, while dietary glutamine supplementation promotes antitumor immunity by exposing differences in plasticity between cancer cells, CD8(+) T cells, and Tregs.
