Review
Dermatology
Monique Aumailley
Summary: The basement membrane at the dermal-epidermal junction is composed of four categories of extracellular matrix proteins, which are precisely arranged through specific interactions. Some proteins are provided by both fibroblasts and keratinocytes, while others are exclusively synthesized by one of the cell types. Further research is needed to determine how the components from fibroblasts are targeted to the junction and integrated with keratinocytes' proteins to form the basement membrane.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zuopeng Wu, Rebecca A. Sweet, Gerard F. Hoyne, Charmaine J. Simeonovic, Christopher R. Parish
Summary: It has been accepted for decades that T lymphocytes and metastasising tumour cells traverse basement membranes (BM) by deploying a battery of degradative enzymes, particularly proteases. However, recent studies suggest that there are other mechanisms that allow cell migration through basement membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuji Kanazawa, Yuri Ikeda-Matsuo, Hiaki Sato, Mamoru Nagano, Satoshi Koinuma, Tatsuo Takahashi, Hirokazu Suzuki, Ryo Miyachi, Yasufumi Shigeyoshi
Summary: Obesity and aging have negative effects on skeletal muscles, especially in terms of basement membrane (BM) construction. This study investigated the impact of a high-fat diet on muscle function and BM formation in young and old mice. The results showed that obesity at a young age promotes BM formation, while this response is less prominent in old age, indicating increased muscle fragility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
J. Sage, J. Renault, R. Domain, K. K. Bojarski, T. Chazeirat, A. Saidi, E. Leblanc, C. Nizard, S. A. Samsonov, R. Kurfurst, G. Lalmanach, F. Lecaille
Summary: This study identified neohesperidin dihydrochalcone (NHDC) as a potent inhibitor of cathepsin S (Cat S), which plays a role in the degradation of extracellular-matrix and basement membrane. NHDC inhibited the hydrolysis of key proteins in the basement membrane and reduced the expression and activity of Cat S in human keratinocytes. Furthermore, NHDC increased the expression of the anti-inflammatory cytokine IL-10 and mediated the STAT3 signaling pathway, leading to the suppression of Cat S expression.
Article
Nutrition & Dietetics
Kyohei Furukawa, Masaya Kono, Tetsuro Kataoka, Yukio Hasebe, Huijuan Jia, Hisanori Kato
Summary: The study found that nutritional supplementation of eggshell membrane (ESM) can have a beneficial effect on maintaining skin health and improving the skin aging process, possibly through upregulating calcium signaling.
Review
Biochemistry & Molecular Biology
Nargess Khalilgharibi, Yanlan Mao
Summary: The basement membrane plays a crucial role in tissue development and diseases, with its complex mechanical properties changing through different molecular mechanisms, thereby affecting tissue form and function. Investigating the mechanical properties of the basement membrane is important for disease diagnosis and treatment, as well as the development of better in silico and in vitro models, which can also reduce the use of animals in research.
Article
Anatomy & Morphology
Heng Chen, Lin Li, Sangang He, Guoliang Sa
Summary: The study showed that during murine oral mucosal rete peg formation, podosomes form at the front of the emerging rete peg and may play a pivotal role in basement membrane remodeling.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Article
Biotechnology & Applied Microbiology
Shaomin Zhi, Jun Li, Xiao Kong, Xuemei Xie, Qiangli Zhang, Guoxiang Fang
Summary: IGF2BP2 plays a crucial role in wound healing by regulating proliferation, migration, and angiogenesis of keratinocytes. Knockdown of IGF2BP2 inhibits these processes in keratinocytes by decreasing the stability of HPSE.
Article
Engineering, Biomedical
Elrade Rofaani, Yong He, Juan Peng, Yong Chen
Summary: This study developed a method to overcome the lack of in vivo-like basement membrane (BM) for in vitro modeling by culturing primordial lung progenitors (PLPs) on an artificial basement membrane (ABM) composed of collagen IV and laminin. The forces generated by the growing epithelial monolayer on the ABM led to geometry-dependent folding and enhanced expression of surfactant protein C and aquaporin 5 compared with a nanofiber-covered substrate. This work emphasizes the importance of recapitulating natural BM for advanced epithelial modeling.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Conor J. Sugden, Valentina Iorio, Lee D. Troughton, Ke Liu, Mychel R. P. T. Morais, Rachel Lennon, George Bou-Gharios, Kevin J. Hamill
Summary: Transgenic expression of LaNt alpha 31 in mice resulted in defects in tissue morphogenesis, including extravascular bleeding, kidney epithelial detachment, tubular dilation, disruption of the epidermal basal cell layer and hair follicle outer root sheath, as well as reduced cell numbers in the liver.
Article
Medicine, Research & Experimental
Xuanli Tang, Feng Wan, Qin Zhu, Tian Ye, Xue Jiang, Haichun Yang
Summary: The study found that IgG subclass was selectively deposited along GBM and/or TBM in DN, with the mixed type of IgG subclass deposition on TBM having more clinical significance. IgG subclass deposition is merely a manifestation or a consequence rather than a cause in DN.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Elrade Rofaani, Boxin Huang, Feng Liang, Juan Peng, Yong Chen
Summary: This study successfully generated airway epithelium using artificial basement membrane (ABM) and human-induced pluripotent stem cells (hiPSCs). The generated pseudostratified airway epithelium consists of multiple cell types and demonstrates advantages over other methods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, General & Internal
Chi Young Jung, Sun-Jae Lee, Min-Kyung Kim, Dong Jik Ahn, In Hee Lee
Summary: This case report presents a rare occurrence of both anti-GBM disease and TBMN in a 20-year-old male patient. With proper treatment, including methylprednisolone and cyclophosphamide, the patient's symptoms improved and there was no evidence of recurrence during follow-up. Further research is needed to better understand the pathogenesis and long-term outcomes of these two diseases occurring concurrently.
Article
Developmental Biology
Veronique Van de Bor, Vincent Loreau, Marilyne Malbouyres, Delphine Cerezo, Audrey Placenti, Florence Ruggiero, Stephane Noselli
Summary: Basement membranes (BM) are essential for organ morphogenesis and function, with Collagen type IV (ColIV) playing a key role in the assembly and integrity of the BM in Drosophila ovarian stalk morphogenesis. The dynamic assembly of ColIV in the stalk is crucial for maintaining ovarian integrity and preventing follicle fusion, highlighting the importance of BM in controlling tissue morphogenesis and integrity.
Article
Multidisciplinary Sciences
Claire Leclech, David Gonzalez-Rodriguez, Aurelien Villedieu, Thevy Lok, Anne-Marie Deplanche, Abdul I. Barakat
Summary: The emergence of a specific pattern of collective cell migration in unconfined endothelial monolayers on microgroove substrates has been demonstrated. This pattern exhibits periodic antiparallel cell streams, which are dependent on intact cell-cell junctions and sensitive to groove depth.
NATURE COMMUNICATIONS
(2022)