Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

(2011) Immanuel Lerner et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKL

(2010) Y. Yang et al.   CANCER RESEARCH

Nuclear Localization of Signal Transducer and Activator of Transcription 3 in Head and Neck Squamous Cell Carcinoma Is Associated with a Better Prognosis

(2010) E. Pectasides et al.   CLINICAL CANCER RESEARCH

Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches

(2010) Stephen Y. Lai et al.   DRUG RESISTANCE UPDATES

Emerging drugs to treat squamous cell carcinomas of the head and neck

(2010) Christopher Fung et al.   EXPERT OPINION ON EMERGING DRUGS

NF-κB and STAT3 signaling in glioma: targets for future therapies

(2010) George P Atkinson et al.   Expert Review of Neurotherapeutics

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis

(2010) Uri Barash et al.   FEBS Journal

Heparanase 2 Interacts with Heparan Sulfate with High Affinity and Inhibits Heparanase Activity

(2010) Flonia Levy-Adam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity

(2010) Vishnu C. Ramani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pre-clinical and clinical significance of heparanase in Ewing’s sarcoma

(2010) Itay Shafat et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tumorigenic and adhesive properties of heparanase

(2010) Flonia Levy-Adam et al.   SEMINARS IN CANCER BIOLOGY

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Structure-Function Approach Identifies a COOH-Terminal Domain That Mediates Heparanase Signaling

(2009) L. Fux et al.   CANCER RESEARCH

A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics

(2009) Uri Barash et al.   FASEB JOURNAL

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

(2009) K. Dredge et al.   INVESTIGATIONAL NEW DRUGS

Heparanase: busy at the cell surface

(2009) Liat Fux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Heparanase Augments Epidermal Growth Factor Receptor Phosphorylation: Correlation with Head and Neck Tumor Progression

(2008) V. Cohen-Kaplan et al.   CANCER RESEARCH

Constitutive Activation of Signal Transducer and Activator of Transcription 5 Contributes to Tumor Growth, Epithelial-Mesenchymal Transition, and Resistance to Epidermal Growth Factor Receptor Targeting

(2008) P. Koppikar et al.   CLINICAL CANCER RESEARCH

Immunohistochemical Analysis of Phosphotyrosine Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor Autocrine Signaling Pathways in Head and Neck Cancers and Metastatic Lymph Nodes

(2008) R. R. Seethala et al.   CLINICAL CANCER RESEARCH

Function of Heparanase in Prostate Tumorigenesis: Potential for Therapy

(2008) I. Lerner et al.   CLINICAL CANCER RESEARCH

Heparanase induces VEGF C and facilitates tumor lymphangiogenesis

(2008) Victoria Cohen-Kaplan et al.   INTERNATIONAL JOURNAL OF CANCER

Heparanase Facilitates Cell Adhesion and Spreading by Clustering of Cell Surface Heparan Sulfate Proteoglycans

(2008) Flonia Levy-Adam et al.   PLoS One

Paradigm shifts in the cell biology of STAT signaling

(2008) Pravin B. Sehgal   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

STAT3: A critical transcription activator in angiogenesis

(2007) Zhong Chen et al.   MEDICINAL RESEARCH REVIEWS