Article
Biotechnology & Applied Microbiology
Shaomin Zhi, Jun Li, Xiao Kong, Xuemei Xie, Qiangli Zhang, Guoxiang Fang
Summary: IGF2BP2 plays a crucial role in wound healing by regulating proliferation, migration, and angiogenesis of keratinocytes. Knockdown of IGF2BP2 inhibits these processes in keratinocytes by decreasing the stability of HPSE.
Review
Immunology
Takahiro Manabe, Heamin Park, Takashi Minami
Summary: Wound healing is a complex process involving multiple cell types and signaling pathways, which can be easily impaired or dysregulated by the microenvironment, leading to the occurrence of various diseases. The calcium signaling pathway plays an important regulatory role in wound healing, affecting the progress of various healing steps.
INFLAMMATION AND REGENERATION
(2021)
Review
Pharmacology & Pharmacy
Lin-Jun Wang, Fei Feng, Jian-Chun Li, Ting-Ting Chen, Li-Ping Liu
Summary: Pulmonary hypertension (PH) is a pathophysiological condition that leads to increased pulmonary circulation vascular resistance, causing right heart dysfunction and even death. Recent studies have shown a close association between heparanase (HPA) and PH, suggesting HPA as a potential therapeutic target and biomarker for PH.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Kang Jin, Eric E. Bardes, Alexis Mitelpunkt, Jake Y. Wang, Surbhi Bhatnagar, Soma Sengupta, Daniel Pomeranz Krummel, Marc E. Rothenberg, Bruce J. Aronow
Summary: This study harmonized datasets from various sources to develop a compendium of gene signature modules, allowing users to interact, explore, and functionally evaluate these modules via the interactive web portal ToppCell. Through this platform, the researchers developed new hypotheses about immune responses to SARS-CoV-2 infection, such as the role of macrophages in T cell recruitment and activation, altered functions of COVID-19-generated platelet subtypes, and the activation network driving B cell maturation in the context of post-viral autoimmunity.
Article
Plant Sciences
Oluwakemi Adeleke, Ganiyu Oboh, Stephen Adefegha, Adebayo Osesusi
Summary: This study demonstrated that the aqueous extracts of Sphenocentrum jollyanum root and leaf can enhance wound healing in diabetic rats by modulating pro-inflammatory cytokines, vascular endothelial growth factor, and microbial colonization.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Mohit Chhabra, Norbert Wimmer, Qi Qi He, Vito Ferro
Summary: PG545 is a highly potent inhibitor of angiogenesis, tumor growth, metastasis, and various HS-dependent viruses, including SARS-CoV-2. New efficient routes for the synthesis of PG545 and analogues have been developed to address low yield and poor selectivity issues in the reported synthesis, with particular focus on improving the key glycosylation step.
BIOCONJUGATE CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Anroop B. Nair, Bapi Gorain, Manisha Pandey, Shery Jacob, Pottathil Shinu, Bandar Aldhubiab, Rashed M. Almuqbil, Heba S. Elsewedy, Mohamed A. Morsy
Summary: Healing wounds is crucial for protecting internal organs, but complications may lead to scars and impact quality of life. This article highlights the potential of tocotrienol in topical wound healing and explores nanotechnological-based carriers to overcome delivery challenges. The findings suggest that tocotrienol could be a viable alternative for wound dressings.
Article
Plant Sciences
Fanxing Xu, Jingxian Wu, Yumei Hu, Chun Chu, Wenjun Liu, Xiang Li, Wen Zheng, Weishuo Yang, Boyan Zhao, Jiangxue Guo, Zhenzhong Wang, Ying Jia, Wei Xiao
Summary: This study aimed to evaluate the pro-healing effect of Tongsaimai (TSM) and its underlying mechanisms using experimental validation and network pharmacology analysis. The results showed that TSM enhanced wound contraction, epithelial cell proliferation, collagen deposition, and had antioxidant and anti-inflammatory effects. The network pharmacology analysis revealed the involvement of multiple pathways in TSM's pharmacological actions on wound healing, including VEGF, PI3K/Akt, and MAPK pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Fei Feng, Lin-Jun Wang, Jian-Chun Li, Ting-Ting Chen, Liping Liu
Summary: This article mainly describes the mechanism of Heparanase (HPA) on Acute Respiratory Distress Syndrome (ARDS), indicating its important role in inflammation, coagulation, and fibrosis. It also speculates that HPA promotes the occurrence and development of ARDS through exosomes and autophagy, resulting in the release of inflammatory factors, coagulation disorder, and pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ha Na Kim, Zehra Elgundi, Xiaoting Lin, Lu Fu, Fengying Tang, Edward S. X. Moh, MoonSun Jung, Keerthana Chandrasekar, Florence Bartlett-Tomasetig, Candice Foster, Nicolle H. Packer, John M. Whitelock, Jelena Rnjak-Kovacina, Megan S. Lord
Summary: Growth factors play a crucial role in angiogenesis for tissue repair and regeneration. However, the clinical success of growth factor delivery has been limited. This study demonstrates that engineered short forms of perlecan can bind and activate angiogenic growth factors. Delivery of these engineered perlecan forms in chitosan scaffolds promotes angiogenesis, making them potential next generation angiogenic therapies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Lutan Zhou, Ronghua Yin, Na Gao, Huifang Sun, Dingyuan Chen, Ying Cai, Lin Ren, Lian Yang, Zhili Zuo, Hongbin Zhang, Jinhua Zhao
Summary: nHG and its derivatives extracted from sea cucumber demonstrate the ability to inhibit heparanase activity and show inhibitory effects on various cancer-related cells and angiogenesis. In addition, they exhibit practical antimetastatic effects in a metastatic mouse model.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Cassidy Whitefield, Yen Vo, Brett D. Schwartz, Caryn Hepburn, F. Hafna Ahmed, Hideki Onagi, Martin G. Banwell, Keats Nelms, Lara R. Malins, Colin J. Jackson
Summary: Heparanase (HPSE) is an important enzyme involved in the degradation of heparan sulfate. Dysfunction of HPSE activity has been linked to various diseases, making it a target for therapeutic programs. Pentosan polysulfate sodium (PPS) is an FDA-approved drug that inhibits HPSE, but its mechanism of action is complex and challenging to characterize.
Article
Chemistry, Multidisciplinary
Junkai Zeng, Changjiang Gu, Xiangwu Geng, Zhong-Yi Wang, Zhi-Chao Xiong, Ying-Jie Zhu, Xiongsheng Chen
Summary: This study developed copper-containing nanoparticles-loaded silicene nanosheets with triple enzyme mimicry catalytic activities and photothermal function, which efficiently eliminate bacteria, promote angiogenesis, and accelerate wound healing.
Article
Chemistry, Applied
Yuanping Hao, Wenwen Zhao, Hao Zhang, Weiping Zheng, Qihui Zhou
Summary: The BP/CS-bFGF hydrogel dressing prepared in this study shows great potential for diabetic chronic wound management. It has strong wet-tissue adhesion, self-mending, and antibacterial properties, and displays fast hemostasis capacity. The hydrogel dressing significantly accelerates full-thickness diabetic wound repair by increasing the production of Ki67, promoting the generation of epithelialization and collagen, inducing the formation of hair follicles, and enhancing neovascularization.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Mingqian Hao, Xiaojuan Peng, Shuwen Sun, Chuanbo Ding, Wencong Liu
Summary: This study reported a multi-functional hydrogel, CAVBPH, which not only improved cell proliferation, angiogenesis, and extracellular matrix secretion, but also reduced inflammation at the wound site. The possible mechanism might be related to the activation of the PI3K/AKT/mTOR and SIRT1/NF-kappa B pathways.
FRONTIERS IN PHARMACOLOGY
(2022)