Article
Biochemistry & Molecular Biology
Annemiek Dickhout, Dawid M. Kaczor, Alexandra C. A. Heinzmann, Sanne L. N. Brouns, Johan W. M. Heemskerk, Marc A. M. J. van Zandvoort, Rory R. Koenen
Summary: After deposition on endothelial cells, CCL5 and CXCL4 are rapidly and actively internalized by the cells, primarily depending on dynamin, clathrin, and G protein-coupled receptors. The chemokines seem to be directed towards the nucleus, with internalization process not impacting leukocyte arrest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Jan K. Hennigs, Christiane Matuszcak, Martin Trepel, Jakob Koerbelin
Summary: Endothelial cells play crucial roles in facilitating physiological processes throughout the body, demonstrating tremendous cellular diversity. Different endothelial cell populations adapt to the specific needs of various organs and tissues, influencing vascular tone, blood coagulation, and cellular adhesion.
Article
Microbiology
Megan C. Mladinich, Jonas N. Conde, William R. Schutt, Sook-Young Sohn, Erich R. Mackow
Summary: Zika virus persistently infects human brain microvascular endothelial cells through the secretion of CCL5, and blocking CCL5 and its receptors CCR3/CCR5 can inhibit the viral spread. Targeting CCL5 responses could be a potential therapeutic approach to prevent Zika virus persistence and neurovirulence.
Review
Nutrition & Dietetics
Hanxu Zhang, Shuang Zhou, Minxue Sun, Manqi Hua, Zhiyan Liu, Guangyan Mu, Zhe Wang, Qian Xiang, Yimin Cui
Summary: The review discusses the role of ferroptosis in endothelial cells in vascular diseases and explores potential therapeutic strategies for treating ferroptosis.
Review
Pharmacology & Pharmacy
Tong Li, Baofu Wang, Hao Ding, Shiqi Chen, Weiting Cheng, Yang Li, Xiaoxiao Wu, Lei Wang, Yangyang Jiang, Ziwen Lu, Yu Teng, Sha Su, Xiaowan Han, Mingjing Zhao
Summary: Atherosclerosis (AS)-related diseases are the leading cause of death in clinical patients. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, and intercellular communication through extracellular vesicles (EVs) is important in the pathophysiology of AS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Medicine, Research & Experimental
Tianying Hong, Xianmei Pan, Han Xu, Zhijuan Zheng, Lizhen Wen, Jing Li, Mingfeng Xia
Summary: Vascular inflammation is a common pathological basis for many cardiovascular diseases. Jatrorrhizine, a component of Rhizoma Coptidis, has been found to reduce carotid intimal hyperplasia and vascular inflammation in mice, and inhibit endothelial cell inflammation induced by H2O2.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Jocelynda Salvador, M. Luisa Iruela-Arispe
Summary: Vascular cells are constantly influenced by physical forces associated with heart activities and vessel geometry, which regulate the transcriptional program and phenotype of these cells in different regions of the vascular tree. The nucleus plays a critical role as a mechanosensor, and maintaining nuclear integrity is essential for proper vascular function and stability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu
Summary: The glycocalyx plays a crucial role in inflammation and the development of vascular diseases, with endothelial dysfunction potentially leading to tissue swelling, chronic inflammation, and thrombosis. Eliminating endothelial inflammation may be a key target for treating vascular diseases. Research indicates that by disrupting the cycle of endothelial dysfunction and inflammation, the glycocalyx can help alleviate the progression of inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pablo C. Caracciolo, Patricia Diaz-Rodriguez, Ines Ardao, David Moreira, Florencia Montini-Ballarin, Gustavo A. Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The study developed bioresorbable small-diameter vascular grafts functionalized with heparin to promote endothelial cell growth and inhibit smooth muscle cells over-proliferation. The tensile properties of the heparin-functionalized vascular grafts resembled those of saphenous veins, indicating potential clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, Research & Experimental
Shijie Liu, Jinzi Wu, Amanda Stolarz, Huiliang Zhang, Marjan Boerma, Stephanie D. Byrum, Nancy J. Rusch, Zufeng Ding
Summary: This study demonstrates the significant impact of PCSK9 on efferocytosis in ECs and its implications in vascular aging. The findings suggest that PCSK9 deficiency can restore efferocytosis and inhibit the expression of aging markers. Treatment with a PCSK9 inhibitor shows potential in improving vascular aging and reducing inflammation.
Article
Biochemistry & Molecular Biology
Su-jeong Choi, Harsha Nagar, Jun Wan Lee, Seonhee Kim, Ikjun Lee, Shuyu Piao, Byeong Hwa Jeon, Cuk-Seong Kim
Summary: This study found that IDH2 deficiency induced increased expression of SDC2 in endothelial cells, with MMP7 and TGF-beta signaling playing regulatory roles. UTI could reverse the increase in SDC2, MMP7, and TGF-beta signaling caused by IDH2 deficiency.
Review
Cardiac & Cardiovascular Systems
Han Jiang, Lihua Li, Lili Zhang, Guangyao Zang, Zhen Sun, Zhongqun Wang
Summary: This study reviews the pathogenesis of vascular calcification, the role of endothelial cells, and the regulatory factors of EndMT, in order to provide new concepts for the prevention and treatment of VC.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Md Zahid Akhter, Jagdish Chandra Joshi, Vijay Avin Balaji Ragunathrao, Mark Maienschein-Cline, Richard L. Proia, Asrar B. Malik, Dolly Mehta
Summary: The study demonstrates the generation of a population of S1PR1(+) EC is crucial for mediating endothelial repair and restoring vascular homeostasis in inflammatory vascular injury states. This transition of cells is induced by S1P and involves key genes such as SPHK1 and SPNS2, which are regulated by transcription factors EGR1 and STAT3.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Laura Soriano-Romani, Fayaz A. Mir, Niharika Singh, Ian Chin, Ali Hafezi-Moghadam, Sharmila Masli
Summary: This study investigates the role of thrombospondin (TSP)-1 in regulating leukocyte recruitment and VCAM-1 expression in mouse models of uveitis. The results show that TSP-1 deficiency can reduce retinal leukocyte adhesion in LPS-mediated acute uveitis, while TSP-1-derived CD47-binding peptide can reduce the clinical disease course and retinal leukocyte adhesion in chronic uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Astrid H. Lossius, Teresa L. Berents, Frank Saetre, Hogne R. Nilsen, Maria Bradley, Samina Asad, Guttorm Haraldsen, Olav Sundnes, Jan-oivind Holm
Summary: The early molecular responses to nb-UVB treatment in AD skin showed significant modulation of gene expression related to inflammatory response, melanin synthesis, and other functions. Interestingly, there was a noted decrease in pro-inflammatory cytokine IL-36 gamma and an increase in anti-inflammatory cytokine IL-37 after treatment with nb-UVB. This study provides important insights into the molecular mechanisms behind the treatment response and indicates potential new treatment targets.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Francesca Gatti, Sobuj Mia, Clara Hammarstrom, Nadine Frerker, Bjarte Fosby, Junbai Wang, Wojciech Pietka, Olav Sundnes, Johanna Hol, Monika Kasprzycka, Guttorm Haraldsen
Summary: IL-33 functions as a cytokine signaling molecule in fibrosis and also plays a role in affecting chromatin folding in the cell nucleus. Knockdown of IL-33 skews transcription profiles towards a myofibroblast phenotype in fibroblasts, leading to enhanced expression of fibrogenic genes and enrichment of gene sets involved in extracellular matrix formation and remodeling.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Lene S. Hoydahl, Terje Frigstad, Ingunn B. Rasmussen, Inger Oynebraten, Karoline W. Schjetne, Jan Terje Andersen, Terje E. Michaelsen, Elin Lunde, Bjarne Bogen, Inger Sandlie
Summary: Different antibody-antigen fusion modes have varying effects on inducing T-cell responses, with Troybody being more effective than fusion of antigen to the C-terminus of antibodies. This approach enhances activation of CD4 and CD8 peptide-specific T cells.
Review
Cardiac & Cardiovascular Systems
Johanna Hol Fosse, Guttorm Haraldsen, Knut Falk, Reidunn Edelmann
Summary: The role of endothelial cells in COVID-19 and other viral infections is crucial, as they impact virus invasion and the body's immune response. The deterioration of endothelial function is closely related to the severity of the disease, highlighting the importance of studying how viruses modulate endothelial cell function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Dermatology
Astrid Haaskjold Lossius, Olav Sundnes, Anna Cacilia Ingham, Sofie Marie Edslev, Jorgen Vildershoj Bjornholt, Berit Lilje, Maria Bradley, Samina Asad, Guttorm Haraldsen, Paal Skytt-Andersen, Jan-Oivind Holm, Teresa Lovold Berents
Summary: The study showed that after 6-8 weeks of nb-UVB treatment, there was an increase in microbial diversity on lesional AD skin, while the microbiota of non-lesional skin and the nose/throat remained unchanged.<Posting on behalf of user>
Article
Cell Biology
Frode Miltzow Skjeldal, Linda Hofstad Haugen, Duarte Mateus, Dominik M. Frei, Anna Vik Rodseth, Xian Hu, Oddmund Bakke
Summary: Rab5 and Rab7a play crucial roles in regulating endosomal progression and maturation. The switch from Rab5 to Rab7a induces the formation of new fully functional early endosomes, which in turn regulates the direction of transport and the homeostasis of early endosomes.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Olav Sundnes, William Ottestad, Camilla Schjalm, Peter Lundback, Lars la Cour Poulsen, Tom Eirik Mollnes, Guttorm Haraldsen, Torsten Eken
Summary: This study observed a rapid and transient surge of IL-33 in a subset of critically injured patients, with more widespread tissue injuries and early coagulopathy. IL-33 displayed a half-life of 1.4 hours, while its decoy receptor sST2 showed a distinctly different pattern.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jonas Aakre Wik, Danh Phung, Shrikant Kolan, Guttorm Haraldsen, Bjorn Steen Skalhegg, Johanna Hol Fosse
Summary: The study shows that inflammatory activation of human umbilical vein endothelial cells by interleukin-1 beta promotes a shift towards a more metabolically active phenotype, driven by shunting of glucose-derived pyruvate into mitochondria. The metabolic response to IL-1 beta varies significantly among donors, highlighting the importance of considering donor-specific responses when targeting dysregulated endothelial cell metabolism.
Review
Immunology
Panagiotis F. Christopoulos, Torleif T. Gjolberg, Stig Kruger, Guttorm Haraldsen, Jan Terje Andersen, Eirik Sundlisaeter
Summary: The Notch signaling pathway plays a supporting role in various inflammation-driven diseases, but targeting this pathway for treatment has proven challenging due to its broad involvement in regenerative and homeostatic processes. Efforts to intervene with the Notch pathway by targeting Notch ligands and/or receptors through distinct therapeutic strategies, including antibody designs, are ongoing. Lessons learned from Notch targeting in cancer treatment may help guide the development of therapeutic strategies for chronic inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Roar Fjaer, Katarzyna Marciniak, Olav Sundnes, Hanne Hjorthaug, Ying Sheng, Clara Hammarstrom, Jan Cezary Sitek, Magnus Dehli Vigeland, Paul Hoff Backe, Ane-Marte Oye, Johanna Hol Fosse, Tor Espen Stav-Noraas, Yuri Uchiyama, Naomichi Matsumoto, Anne Comi, Jonathan Pevsner, Guttorm Haraldsen, Kaja Kristine Selmer
Summary: Sturge-Weber syndrome (SWS) is a neurocutaneous disorder characterized by vascular malformations, often caused by a somatic missense mutation in the GNAQ gene. This study identified a novel somatic mutation in the GNB2 gene in one SWS patient, which affects G-protein complex reassembly and downstream signaling pathways. Both mutations decreased cellular proliferation and YAP synthesis, suggesting a key role for the Hippo signaling pathway in SWS vascular pathogenesis.
HUMAN MOLECULAR GENETICS
(2021)
Correction
Cell Biology
Xian Hu, Salma Jalal, Michael Sheetz, Oddmund Bakke, Felix Margadant
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Katharina Vestre, Irene Persiconi, Marita Borg Distefano, Nadia Mensali, Noemi Antonella Guadagno, Marine Bretou, Sebastien Walchli, Catharina Arnold-Schrauf, Oddmund Bakke, Marc Dalod, Ana-Maria Lennon-Dumenil, Cinzia Progida
Summary: The study highlights the essential role of Rab7b in regulating dendritic cell migration, influencing the movement and antigen presentation process through controlling lysosomal signaling and interacting with the actomyosin cytoskeleton.
JOURNAL OF CELL SCIENCE
(2021)
Article
Immunology
Gaoyang Li, Shrikant Shantilal Kolan, Shuai Guo, Katarzyna Marciniak, Pratibha Kolan, Giulia Malachin, Franco Grimolizzi, Guttorm Haraldsen, Bjorn Steen Skalhegg
Summary: The development of Delayed-type hypersensitivity arthritis (DTHA) in mice involves increased levels of activated, pro-inflammatory Th1, Th17, and memory CD4+ T cells with differential dynamic patterns, while B cells seem to not be involved. Methotrexate (MTX) and dexamethasone (DEX) can suppress DTHA-induced paw swelling and inflammation by regulating levels of Th1, Th17, memory T cells, and B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mona Dixon Gundersen, Kenneth Bowitz Larsen, Kay Martin Johnsen, Rasmus Goll, Jon Florholmen, Guttorm Haraldsen
Summary: This study found that IL-33 in colonic mucosa is mainly induced by hypo-osmotic stress rather than inflammatory cytokines. This novel finding links a potent cytokine and alarmin of the innate immune system with cellular stress mechanisms and mucosal inflammation.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Siri Hansen Stabell, Anastasia Renzi, Hogne Roed Nilsen, Olaf Harald Antonsen, Johanna Hol Fosse, Guttorm Haraldsen, Olav Sundnes
Summary: Notch signalling plays a crucial role in multiple human diseases, but the activation status of Notch signalling in patients with familial hidradenitis suppurativa (HS) has not been thoroughly studied. This study established immunostaining protocols to identify activated Notch receptors in human skin tissue and confirmed the ability to detect changes in Notch activation using an ex vivo skin organ model. The results showed the distribution of active Notch signalling in human apocrine-bearing skin and demonstrated a reduced activation of Notch in the epidermis of lesional HS.
EXPERIMENTAL DERMATOLOGY
(2023)