Article
Biochemical Research Methods
Mohit Chhabra, Norbert Wimmer, Qi Qi He, Vito Ferro
Summary: PG545 is a highly potent inhibitor of angiogenesis, tumor growth, metastasis, and various HS-dependent viruses, including SARS-CoV-2. New efficient routes for the synthesis of PG545 and analogues have been developed to address low yield and poor selectivity issues in the reported synthesis, with particular focus on improving the key glycosylation step.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Upasana Ray, Prabhu Thirusangu, Ling Jin, Yinan Xiao, Christopher L. Pathoulas, Julie Staub, Courtney L. Erskine, Keith Dredge, Edward Hammond, Matthew S. Block, Scott H. Kaufmann, Jamie N. Bakkum-Gamez, Viji Shridhar
Summary: PG545 is a highly sulfated small molecule that inhibits heparanase and disrupts signaling mediated by heparan-binding-growth factors. It induces DNA damage in ovarian cancer cells by inducing DNA single- and double-strand breaks, reducing RAD51 expression, and inhibiting homologous recombination repair. PG545 also synergizes with PARP inhibitors in ovarian cancer cell lines and primary cultures of patient-derived ascites samples. In addition, it shows increased antitumor effects and survival in xenograft and immunocompetent syngeneic OC models. Targeting DEK-HSPG interactions through PG545 may inhibit DNA repair and sensitize cells to PARP inhibitors.
Article
Biochemistry & Molecular Biology
Yasmin Kayal, Preeti Singh, Inna Naroditsky, Neta Ilan, Israel Vlodavsky
Summary: Hpa2 shows tumor suppressor function in pancreatic cancer, with high levels associated with improved patient survival and significant impact on tumor growth in experiments. The study found that Hpa2 enhances endoplasmic reticulum stress response, making cells more sensitive to external stress and promoting apoptosis.
Article
Biochemistry & Molecular Biology
Ibrahim Knani, Yifat Yanku, Miriam Gross-Cohen, Neta Ilan, Israel Vlodavsky
Summary: The role of Hpa2 in cancer is not fully understood, but in sarcoma, it has been found to attenuate tumor growth, affect apoptotic cell death, and reduce stem cell characteristics. It may also be involved in the interaction with the extracellular matrix.
Article
Biochemistry & Molecular Biology
Miriam Gross-Cohen, Yifat Yanku, Ofra Kessler, Uri Barash, Ilanit Boyango, Angel Cid-Arregui, Gera Neufeld, Neta Ilan, Israel Vlodavsky
Summary: The study indicates that Hpa2 functions as a tumor suppressor in head and neck cancer by increasing cytokeratin expression and upregulating Sox2. Silencing Sox2 results in larger tumors, while overexpression of Sox2 leads to smaller tumors.
Article
Cell Biology
Valerie Borel, Stefan Boeing, Niek Van Wietmarschen, Sriram Sridharan, Bethany Rebekah Hill, Luigi Ombrato, Jimena Perez-Lloret, Deb Jackson, Robert Goldstone, Simon J. Boulton, Andre Nussenzweig, Roberto Bellelli
Summary: The maintenance of genome stability relies on coordinated control of origin activation and replication fork progression. This study shows that mouse cells with Pole instability have impaired genome-wide activation of DNA replication origins. Interestingly, Trp53 ablation in these cells increases Pole levels and origin activation, reducing DNA damage. Transcriptome analysis reveals that the TRP53-CDKN1A/P21 axis maintains appropriate levels of replication factors and CDK activity during S phase. Loss of this control mechanism deregulates origin activation and perturbs genome-wide replication fork progression. These findings suggest the importance of this axis in maintaining genome stability and provide insights into genetic diseases and cancer.
Article
Oncology
Lee-or Herzog, Beth Walters, Roberta Buono, J. Scott Lee, Sharmila Mallya, Amos Fung, Honyin Chiu, Nancy Nguyen, Boyang Li, Anthony B. Pinkerton, Michael R. Jackson, Robert J. Schneider, Ze'ev A. Ronai, David A. Fruman
Summary: This study identified that using SBI-756 in lymphoma cells can synergize with Venetoclax to induce apoptosis, enhancing its efficacy. SBI-756 prevents eIF4E-eIF4G1 association and cap-dependent translation, reducing protein synthesis rates and selectively affecting sensitive cells.
BRITISH JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Abhijit S. Naik, Su Q. Wang, Mahboob Chowdhury, Jawad Aqeel, Christopher L. O'Connor, Jocelyn E. Wiggins, Markus Bitzer, Roger C. Wiggins
Summary: The study showed that starting ACE inhibitor before nephrectomy can reduce compensatory glomerular volume increase, leading to prevention of progression of proteinuria and glomerulosclerosis.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Guofeng Xie, Zhongsheng Peng, Jinqing Liang, Shannon M. Larabee, Cinthia B. Drachenberg, Harris Yfantis, Jean-Pierre Raufman
Summary: Zinc finger protein 277 is overexpressed in colon cancer and regulates cellular proliferation and senescence, affecting intestinal homeostasis and neoplasia.
Article
Agriculture, Dairy & Animal Science
Yanan Chen, Hao Zhang, Yue Li, Shuli Ji, Peilu Jia, Tian Wang
Summary: Pterostilbene mitigates ER stress and promotes autophagic flux, improving colon inflammation and barrier dysfunction in IUGR piglets and TNF-alpha-treated Caco-2 cells.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Oncology
Xueliang Gao, Yubao Wang, Caroline F. Ribeiro, Cherubin Manokaran, Hyeyoun Chang, Thanh Von, Silvia Rodrigues, Onur Cizmecioglu, Shidong Jia, Manav Korpal, Joshua M. Korn, Zhigang Wang, Fabienne Schmit, Lan Jiang, Raymond Pagliarini, Yi Yang, Isha Sethi, Sabina Signoretti, Guo-Cheng Yuan, Massimo Loda, Jean J. Zhao, Thomas M. Roberts
Summary: Research findings suggest that blocking p110 beta can slow down the progression of castration-resistant prostate cancer and reduce tumor growth. Combining p110 beta with other inhibitors shows potential for treating CRPC.
MOLECULAR CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Britt-Marie Iresjo, Lisa Diep, Kent Lundholm
Summary: High amino acid concentrations can increase IGF-1 mRNA expression and stimulate muscle protein synthesis, but the upregulation of IGF-1 mRNA does not directly lead to an increase in protein synthesis by amino acids. This suggests that amino acid-induced protein synthesis in non-proliferating muscle cells may be related to unrecognized metabolic activities.
Article
Chemistry, Medicinal
Xintao Gao, Yonglong Jin, Wenyong Zhu, Xiaochen Wu, Jing Wang, Chuanlong Guo
Summary: eIF4E is a central regulator in cancer cell growth, but there are currently no clinically available eIF4E inhibitors. Interfering with eIF4E/eIF4G interactions may provide a new strategy for designing eIF4E inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Lifen Wang, Gang Sheng, Jinjun Cui, Yanling Yao, Xue Bai, Fan Chen, Wei Yu
Summary: This study found that electroacupuncture can significantly attenuate ischemic injury after stroke and promote angiogenesis via activation of EPO-mediated Src and VEGF signaling pathways.
Article
Oncology
Sandip H. Patel, Tiffany L. George, Tzu-Fei Wang, Sherry M. Vogt, Edmund Folefac, Menglin Xu, Yuanquan Yang, Anish B. Parikh, Claire F. Verschraegen, Steven K. Clinton, Ming Yin
Summary: Concurrent treatment with VEGFR TKIs and LMWH was associated with a significantly increased risk of bleeding events in cancer patients compared to LMWH therapy alone. Caution should be taken when considering this combination treatment for some patients.
Article
Gastroenterology & Hepatology
Bella Ungar, Uri Kopylov, Miri Yavzori, Ella Fudim, Orit Picard, Adi Lahat, Daniel Coscas, Matti Waterman, Ola Haj-Natour, Noam Orbach-Zingboim, Ren Mao, Minhu Chen, Yehuda Chowers, Rami Eliakim, Shomron Ben-Horin
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
Renaud Gaujoux, Elina Starosvetsky, Naama Maimon, Francesco Vallania, Haggai Bar-Yoseph, Sigal Pressman, Roni Weisshof, Idan Goren, Keren Rabinowitz, Matti Waterman, Henit Yanai, Iris Dotan, Edmond Sabo, Yehuda Chowers, Purvesh Khatri, Shai S. Shen-Orr
Article
Public, Environmental & Occupational Health
Mira Y. Friedman, Maya Leventer-Roberts, Joseph Rosenblum, Nir Zigman, Iris Goren, Vered Mourad, Natan Lederman, Nurit Cohen, Eran Matz, Doron Z. Dushnitzky, Nirit Borovsky, Moshe B. Hoshen, Gili Focht, Malka Avitzour, Yael Shachar, Yehuda Chowers, Rami Eliakim, Shomron Ben-Horin, Shmuel Odes, Doron Schwartz, Iris Dotan, Eran Israeli, Zohar Levi, Eric I. Benchimol, Ran D. Balicer, Dan Turner
CLINICAL EPIDEMIOLOGY
(2018)
Article
Gastroenterology & Hepatology
Uri Kopylov, Irit Avni-Biron, Yulia Ron, Benjamin Koslowsky, Matti Waterman, Saleh Daher, Bella Ungar, Doron Schwartz, Eran Zittan, Michal Openhaim, Henit Yanai, Nitsan Maharshak, Ariella Bar Gil Shitrit, Timna Naftali, Rami Eliakim, Yehuda Chowers, Shomron Ben-Horin, Iris Dotan
DIGESTIVE AND LIVER DISEASE
(2019)
Review
Medicine, General & Internal
Shomron Ben-Horin, Yue Zhao, Jing Guo, Ren Mao, Lena Novack, Ruslan Sergienko, Jian Zhang, Taku Kobayashi, Toshifumi Hibi, Yehuda Chowers, Jean Frederic Colombel, Laurent Peyrin-Biroulet, Gilaad Kaplan, Min-hu Chen
Article
Gastroenterology & Hepatology
Shomron Ben-Horin, Adi Lahat, Marianne M. Amitai, Eyal Klang, Doron Yablecovitch, Sandra Neuman, Nina Levhar, Limor Selinger, Noa Rozendorn, Dan Turner, Yehuda Chowers, Shmuel Odes, Doron Schwartz, Henit Yanai, Iris Dotan, Tzipi Braun, Yael Haberman, Uri Kopylov, Rami Eliakim
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2019)
Article
Gastroenterology & Hepatology
Haggai Bar-Yoseph, Sigal Pressman, Alexandra Blatt, Shiran Gerassy Vainberg, Naama Maimon, Elina Starosvetsky, Bella Ungar, Shomron Ben-Horin, Shai S. Shen-Orr, Yehuda Chowers
Article
Gastroenterology & Hepatology
Haggai Bar-Yoseph, Haneen Daoud, Dana Ben Hur, Yehuda Chowers, Matti Waterman
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2020)
Article
Gastroenterology & Hepatology
Ariella Bar-Gil Shitrit, Ami Ben-Ya'acov, Matan Siterman, Matti Waterman, Ayal Hirsh, Doron Schwartz, Eran Zittan, Yehonatan Adler, Benjamin Koslowsky, Irit Avni-Biron, Yehuda Chowers, Yulia Ron, Eran Israeli, Bella Ungar, Henit Yanai, Nitsan Maharshak, Shomron Ben-Horin, Rami Eliakim, Iris Dotan, Eran Goldin, Uri Kopylov
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2020)
Article
Gastroenterology & Hepatology
Nina Levhar, Bella Ungar, Uri Kopylov, Ella Fudim, Miri Yavzori, Orit Picard, Ninette Amariglio, Yehuda Chowers, Yonat Shemer-Avni, Ren Mao, Min-hu Chen, Ziyin Ye, Rami Eliakim, Shomron Ben-Horin
INFLAMMATORY BOWEL DISEASES
(2020)
Article
Oncology
Erez Hasnis, Aviva Dahan, Wissam Khoury, Daniel Duek, Yael Fisher, Alex Beny, Yuval Shaked, Yehuda Chowers, Elizabeth E. Half
FRONTIERS IN ONCOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Pnina Shitrit, Ravid Mudrik, Bat-Sheva Gottesman, Michal Y. Chowers
Summary: Monitoring surgical site infections after cesarean section is difficult due to the large number of surgeries. A study compared manual chart reviews to an algorithm for identifying infections, with the algorithm achieving high sensitivity (97.5%) and specificity (83.9%), reducing workload for infection control personnel.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Hadar Mudrik-Zohar, Michal Chowers, Elizabeth Temkin, Pnina Shitrit
Summary: This study found that detailed department-level investigations of nosocomial bloodstream infections (NBSIs) performed by healthcare providers, along with increased staff awareness and frontline ownership, were associated with a significant decrease in NBSI rates hospitalwide.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Review
Medicine, General & Internal
Yehuda Chowers
RAMBAM MAIMONIDES MEDICAL JOURNAL
(2019)
Article
Gastroenterology & Hepatology
H. Bar-Yoseph, N. Levhar, L. Selinger, U. Manor, M. Yavzori, O. Picard, E. Fudim, U. Kopylov, R. Eliakim, S. Ben-Horin, Y. Chowers, B. Ungar
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2018)