Review
Pharmacology & Pharmacy
Lin-Jun Wang, Fei Feng, Jian-Chun Li, Ting-Ting Chen, Li-Ping Liu
Summary: Pulmonary hypertension (PH) is a pathophysiological condition that leads to increased pulmonary circulation vascular resistance, causing right heart dysfunction and even death. Recent studies have shown a close association between heparanase (HPA) and PH, suggesting HPA as a potential therapeutic target and biomarker for PH.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Fei Feng, Lin-Jun Wang, Jian-Chun Li, Ting-Ting Chen, Liping Liu
Summary: This article mainly describes the mechanism of Heparanase (HPA) on Acute Respiratory Distress Syndrome (ARDS), indicating its important role in inflammation, coagulation, and fibrosis. It also speculates that HPA promotes the occurrence and development of ARDS through exosomes and autophagy, resulting in the release of inflammatory factors, coagulation disorder, and pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Hematology
Alicia S. Eustes, Robert A. Campbell, Elizabeth A. Middleton, Neal D. Tolley, Bhanu K. Manne, Emilie Montenont, Jesse W. Rowley, Krystin Krauel, Antoinette Blair, Li Guo, Yasuhiro Kosaka, Isabel M. Medeiros-de-Moraes, Marcus Lacerda, Eugenio D. Hottz, Hugo Castro Faria Neto, Guy A. Zimmerman, Andrew S. Weyrich, Aaron Petrey, Matthew T. Rondina
Summary: During clinical sepsis, translation and enzymatic activity of HPSE are increased in platelets. Increased expression of the active form of HPSE protein is associated with sepsis-associated mortality.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Chemistry, Multidisciplinary
Yicong Zhang, Yuai Li, Shiqi Huang, Hanming Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: Metastasis is a crucial factor in cancer-related deaths, and suppressing it can improve the survival rate of cancer patients. Nanoparticles with dual functionality have been developed to inhibit tumor metastasis and enhance the efficacy of loaded drugs against tumors. These versatile carriers show promise in treating invasive solid tumors and metastases by significantly reducing metastatic nodules.
Article
Medicine, General & Internal
Huan-Min Chiu, Wen- Yi Chiou, Wei-Jie Hsu, Li-Hsien Wu, Ming-Hui Yang, Yu-Chang Tyan, Che-Hsin Lee
Summary: The study demonstrates that Salmonella inhibits tumor metastasis by reducing heparanase expression, leading to a decrease in the number of metastatic nodules and an increase in survival time.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Erin Diane Lewis, Dayong Wu, Simin Nikbin Meydani
Summary: Immunosenescence refers to age-related changes in the immune system, characterized by complex alterations in immune function and dysregulation of inflammatory processes. These changes include alterations in innate immune responses and a decline in the number and function of T cells, which can contribute to increased susceptibility to infection and cancer in older adults. Additionally, older adults have higher levels of inflammatory mediators circulating in their bodies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Oncology
Saeed H. Manjili, Madison Isbell, Negar Ghochaghi, Tyler Perkinson, Masoud H. Manjili
Summary: Inflammation plays a complex role in tumor development and recurrence. The type and duration of inflammation are crucial factors in determining the outcome. Chronic inflammation, driven by type I cells and cytokines, can facilitate tumor formation and retain transformed cells in a dormant state. Elevated type II inflammation and inefficient resolution of type I inflammation can delay wound healing and promote the reawakening of dormant tumor cells, leading to disease recurrence.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Microbiology
Jianwei Yu, Yan Zhou, Haodang Luo, Xiaoling Su, Tian Gan, Jingyun Wang, Zufeng Ye, Zhongliang Deng, Jun He
Summary: Mycoplasma genitalium is a newly emerged sexually transmitted disease pathogen that is an independent risk factor for female cervicitis and pelvic inflammatory disease. The clinical symptoms caused by M. genitalium infection are mild and easily ignored. If left untreated, M. genitalium can grow along the reproductive tract and cause salpingitis, leading to infertility and ectopic pregnancy. Additionally, M. genitalium infection in late pregnancy can increase the incidence of preterm birth.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ibrahim Knani, Yifat Yanku, Miriam Gross-Cohen, Neta Ilan, Israel Vlodavsky
Summary: The role of Hpa2 in cancer is not fully understood, but in sarcoma, it has been found to attenuate tumor growth, affect apoptotic cell death, and reduce stem cell characteristics. It may also be involved in the interaction with the extracellular matrix.
Article
Biochemistry & Molecular Biology
Yasmin Kayal, Preeti Singh, Inna Naroditsky, Neta Ilan, Israel Vlodavsky
Summary: Hpa2 shows tumor suppressor function in pancreatic cancer, with high levels associated with improved patient survival and significant impact on tumor growth in experiments. The study found that Hpa2 enhances endoplasmic reticulum stress response, making cells more sensitive to external stress and promoting apoptosis.
Article
Microbiology
Yuanyuan Lei, Li Tang, Shuang Liu, Shiping Hu, Lingyi Wu, Yaojiang Liu, Min Yang, Shengjie Huang, Xuefeng Tang, Tao Tang, Xiaoyan Zhao, Israel Vlodavsky, Shuo Zeng, Bo Tang, Shiming Yang
Summary: Heparanase exacerbates acute pancreatitis through its interaction with the gut microbiota, particularly the commensal Parabacteroides. In addition, Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis by reducing neutrophil infiltration, suggesting a potential therapeutic strategy for acute pancreatitis.
Article
Engineering, Chemical
Mengling Liu, Qing Liu, Yitao Yuan, Suyao Li, Yu Dong, Li Liang, Zhiguo Zou, Tianshu Liu
Summary: This study identified a potential predictive biomarker for immunotherapy efficacy in pMMR mCRC, showing that high HPSE expression is associated with immune checkpoint molecules, tumor mutation burden, and macrophage infiltration. It suggests that pMMR mCRC patients with high HPSE expression may respond to immune checkpoint inhibitors.
Article
Biochemistry & Molecular Biology
Miriam Gross-Cohen, Yifat Yanku, Ofra Kessler, Uri Barash, Ilanit Boyango, Angel Cid-Arregui, Gera Neufeld, Neta Ilan, Israel Vlodavsky
Summary: The study indicates that Hpa2 functions as a tumor suppressor in head and neck cancer by increasing cytokeratin expression and upregulating Sox2. Silencing Sox2 results in larger tumors, while overexpression of Sox2 leads to smaller tumors.
Article
Biochemistry & Molecular Biology
Gina Cavaliere, Angela Catapano, Giovanna Trinchese, Fabiano Cimmino, Ciro Menale, Lidia Petrella, Maria Pina Mollica
Summary: Obesity is a prevalent disorder caused by an imbalance between energy consumption and metabolizable energy intake. Aging further disrupts this balance and impairs the mechanisms controlling energy homeostasis. It results in excessive fat deposition, systemic inflammation, higher levels of free fatty acids, and ectopic lipid accumulation in adipocytes. Chronic liver disease is often associated with hepatic fat accumulation, which is characterized by mitochondrial dysfunction, impaired fat metabolism, and increased oxidative stress. This study investigates the interaction between adipose tissue and the liver, focusing on changes in hepatic mitochondrial fatty acid oxidation and storage during high-fat diet-induced obesity in a rodent model. The results demonstrate that both obesity and aging lead to dysregulation of adipose tissue function, metabolic alterations, and mitochondrial dysfunction, with aging exacerbating liver mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Amit Bery, Hailey M. Shepherd, Wenjun Li, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel
Summary: Tertiary lymphoid organs (TLOs) are immune cell collections that form in non-lymphoid tissues in response to local chronic inflammation. They have complex structures and can generate strong immune responses at sites of tissue injury. Despite our improved understanding of TLO formation and function, their role in chronic inflammatory diseases remains unclear.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)