Metabolism of tissue macrophages in homeostasis and pathology

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

(2021) Paras S. Minhas et al.   NATURE

Epigenetic Regulation of Kupffer Cell Function in Health and Disease

(2021) Hunter Bennett et al.   Frontiers in Immunology

Fa(c)t checking: How fatty acids shape metabolism and function of macrophages and dendritic cells

(2021) Luís Almeida et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

Heme catabolism by tumor-associated macrophages controls metastasis formation

(2021) Francesca Maria Consonni et al.   NATURE IMMUNOLOGY

Tissue-resident macrophages: guardians of organ homeostasis

(2021) Samuel Philip Nobs et al.   TRENDS IN IMMUNOLOGY

Immunometabolism of Tissue-Resident Macrophages – An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies

(2021) Giulia Zago et al.   Frontiers in Immunology

Metabolic orchestration of the wound healing response

(2021) Sabine A. Eming et al.   Cell Metabolism

Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance

(2021) Xiaopeng Li et al.   Cell Reports

Targeting Macrophages in Atherosclerosis

(2021) Dan Hu et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Lighting Up Live-Cell and In Vivo Central Carbon Metabolism with Genetically Encoded Fluorescent Sensors

(2020) Zhuo Zhang et al.   Annual Review of Analytical Chemistry

Krebs Cycle Reborn in Macrophage Immunometabolism

(2020) Dylan G. Ryan et al.   Annual Review of Immunology

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

(2020) Pan Su et al.   CANCER RESEARCH

Efficacy of combination therapy with ezetimibe and statins versus a double dose of statin monotherapy in participants with hypercholesterolemia: a meta-analysis of literature

(2020) Min Yu et al.   Lipids in Health and Disease

Functional and Metabolic Characterization of Microglia Culture in a Defined Medium

(2020) Alejandro Montilla et al.   Frontiers in Cellular Neuroscience

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

(2020) Ana Rakita et al.   Scientific Reports

Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge

(2020) Urszula Brykczynska et al.   Cell Reports

The Interplay Between Tissue Niche and Macrophage Cellular Metabolism in Obesity

(2020) Sabine Daemen et al.   Frontiers in Immunology

Growth Hormone Supplementation May Not Improve Live Birth Rate in Poor Responders

(2020) Jinliang Zhu et al.   Frontiers in Endocrinology

Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity

(2020) Lucie Orliaguet et al.   Frontiers in Endocrinology

Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis

(2020) Ira Tabas et al.   CIRCULATION RESEARCH

Microglial metabolic flexibility supports immune surveillance of the brain parenchyma

(2020) Louis-Philippe Bernier et al.   Nature Communications

RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression

(2020) María Casanova-Acebes et al.   Nature Communications

Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response

(2020) Clotilde Lauro et al.   Frontiers in Immunology

Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche that Maintains and Replenishes Splenic Red Pulp Macrophages

(2020) Alicia Bellomo et al.   IMMUNITY

Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases

(2020) Maria K. Skytthe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes

(2020) Veronica D. Dahik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis

(2020) Chenzhi Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneous origins and functions of mouse skeletal muscle-resident macrophages

(2020) Xingyu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

(2020) Luis Felipe Campesato et al.   Nature Communications

Not Chopped Liver—A Careful, Fate-Mapping Study of Macrophages in NASH

(2020) Maria E. Moreno-Fernandez et al.   Cell Metabolism

Immunometabolism in the Single-Cell Era

(2020) Maxim N. Artyomov et al.   Cell Metabolism

Itaconate controls the severity of pulmonary fibrosis

(2020) Patricia P. Ogger et al.   Science Immunology

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

(2020) Rafael J. Argüello et al.   Cell Metabolism

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

(2020) Jeroen Baardman et al.   Nature Communications

Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis

(2020) Jule Taubmann et al.   Scientific Reports

Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair

(2020) William P. Lafuse et al.   Cells

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

(2019) Alex J. Freemerman et al.   JOURNAL OF IMMUNOLOGY

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal

(2019) Mingen Liu et al.   NATURE IMMUNOLOGY

Vitamin D Is Required for ILC3 Derived IL-22 and Protection From Citrobacter rodentium Infection

(2019) Yang-Ding Lin et al.   Frontiers in Immunology

Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift

(2019) Jung Eun Park et al.   ONCOGENE

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

(2019) Alanna M. Cameron et al.   NATURE IMMUNOLOGY

Microglia-Specific Metabolic Changes in Neurodegeneration

(2019) Blanca I. Aldana   JOURNAL OF MOLECULAR BIOLOGY

Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges

(2019) Hernandez Moura Silva et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage metabolism: a wound‐healing perspective

(2019) George Caputa et al.   IMMUNOLOGY AND CELL BIOLOGY

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

(2019) Pieter Goossens et al.   Cell Metabolism

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

(2019) Christopher J. Halbrook et al.   Cell Metabolism

The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis

(2019) Sarah J Allden et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification and transcriptome analysis of erythroblastic island macrophages

(2019) Wei Li et al.   BLOOD

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

(2019) Freya R. Svedberg et al.   NATURE IMMUNOLOGY

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration

(2019) Nikolas Giannakis et al.   NATURE IMMUNOLOGY

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

(2019) Maisa C. Takenaka et al.   NATURE NEUROSCIENCE

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Metabolic adaptations of tissue-resident immune cells

(2019) George Caputa et al.   NATURE IMMUNOLOGY

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

(2019) Jade D. Bailey et al.   Cell Reports

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

(2019) Johnny Bonnardel et al.   IMMUNITY

Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression

(2019) Anders Etzerodt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis

(2019) Linlin Gu et al.   Redox Biology

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

(2019) Mashito Sakai et al.   IMMUNITY

Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor

(2019) Jing-Yiing Wu et al.   MOLECULAR CELL

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

(2019) Marco Di Gioia et al.   NATURE IMMUNOLOGY

Understanding the Heterogeneity of Resident Liver Macrophages

(2019) Camille Blériot et al.   Frontiers in Immunology

Aerobic glycolysis is a metabolic requirement to maintain the M2-like polarization of tumor-associated macrophages

(2019) Natália M. de-Brito et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses

(2019) Yiliang Chen et al.   CIRCULATION RESEARCH

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

Origin and ontogeny of lung macrophages: from mice to humans

(2019) Elza Evren et al.   IMMUNOLOGY

Immune monitoring using mass cytometry and related high-dimensional imaging approaches

(2019) Felix J. Hartmann et al.   Nature Reviews Rheumatology

Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack

(2019) Jarren R. Oates et al.   Frontiers in Immunology

Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses

(2019) Anfray et al.   Cells

Mapping macrophage polarization over the myocardial infarction time continuum

(2018) Alan J. Mouton et al.   BASIC RESEARCH IN CARDIOLOGY

Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses

(2018) Kshipra Singh et al.   CANCER RESEARCH

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

(2018) Graeme I. Lancaster et al.   Cell Metabolism

Origin and specialization of splenic macrophages

(2018) Noelia A-Gonzalez et al.   CELLULAR IMMUNOLOGY

Niche signals and transcription factors involved in tissue-resident macrophage development

(2018) Wouter T'Jonck et al.   CELLULAR IMMUNOLOGY

Macrophages and lipid metabolism

(2018) Anneleen Remmerie et al.   CELLULAR IMMUNOLOGY

Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases CCR7 Expression in Plaque Macrophages

(2018) Paul A. Mueller et al.   CIRCULATION

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

(2018) Lily Boutens et al.   DIABETOLOGIA

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques

(2018) Lukas Tomas et al.   EUROPEAN HEART JOURNAL

Growth ofMycobacterium tuberculosisin vivo segregates with host macrophage metabolism and ontogeny

(2018) Lu Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of Kupffer cells in hepatic iron and lipid metabolism

(2018) Charlotte L. Scott et al.   JOURNAL OF HEPATOLOGY

Metformin reverses established lung fibrosis in a bleomycin model

(2018) Sunad Rangarajan et al.   NATURE MEDICINE

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

(2018) David A. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue

(2018) Vlad Serbulea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin Does Not Affect Clinically Relevant Outcomes in Patients with Idiopathic Pulmonary Fibrosis

(2018) Paolo Spagnolo et al.   RESPIRATION

Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major

(2018) Shanshan Hu et al.   Frontiers in Immunology

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

(2018) Feilong Wang et al.   Cell Metabolism

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

(2018) Charlotte L. Scott et al.   IMMUNITY

A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses

(2018) Jérémy Postat et al.   IMMUNITY

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

(2018) Jonathan M. Weiss et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages of distinct origins contribute to tumor development in the lung

(2018) Pierre-Louis Loyher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

(2018) Xuchu Que et al.   NATURE

Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis

(2018) Cormac McCarthy et al.   Nature Communications

Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney

(2018) Amrutesh S. Puranik et al.   Scientific Reports

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function

(2018) Helena M. Izquierdo et al.   Cell Reports

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

(2018) Duco Steven Koenis et al.   Cell Reports

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

(2018) Kyeongdae Kim et al.   CIRCULATION RESEARCH

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

(2018) Jeroen Baardman et al.   Cell Reports

Bioenergetic regulation of microglia

(2017) Soumitra Ghosh et al.   GLIA

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment

(2017) Frederic Sierro et al.   IMMUNITY

The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

(2017) Xueyang Yu et al.   IMMUNITY

Hyaluronan carried by tumor-derived microvesicles induces IL-10 production in classical (CD14 ++ CD16 − ) monocytes via PI3K/Akt/mTOR-dependent signalling pathway

(2017) Marzena Lenart et al.   IMMUNOBIOLOGY

Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis

(2017) Risa Ebina-Shibuya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Higher phagocytic activity of thioglycollate-elicited peritoneal macrophages is related to metabolic status of the cells

(2017) Sofia Pavlou et al.   Journal of Inflammation-London

Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

(2017) Roksana M Pirzgalska et al.   NATURE MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

“Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels

(2017) Manfred Nairz et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

(2017) Charles Sinclair et al.   SCIENCE

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

(2017) Michael F. Cuccarese et al.   Nature Communications

Accelerated Healing of Diabetic Wounds Treated with L-Glutamic acid Loaded Hydrogels Through Enhanced Collagen Deposition and Angiogenesis: An In Vivo Study

(2017) Ponrasu Thangavel et al.   Scientific Reports

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

(2017) Brittney R. Coats et al.   Cell Reports

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

(2017) Erika M. Palmieri et al.   Cell Reports

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

(2017) Xunde Xian et al.   eLife

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity

(2017) Xenia Geeraerts et al.   Frontiers in Immunology

Obesity and Cancer Metabolism: A Perspective on Interacting Tumor–Intrinsic and Extrinsic Factors

(2017) Steven S. Doerstling et al.   Frontiers in Oncology

Metabolic properties of the osteoclast

(2017) Timothy R. Arnett et al.   BONE

Targeting cholesterol homeostasis in lung diseases

(2017) Anthony Sallese et al.   Scientific Reports

Surfactant Lipids at the Host–Environment Interface. Metabolic Sensors, Suppressors, and Effectors of Inflammatory Lung Disease

(2016) Michael B. Fessler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of AtherosclerosisHighlights

(2016) Annemarie Aarup et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Akt isoform-dependent regulation of ATP-Binding cassette A1 expression by apolipoprotein E

(2016) Emmanuel U. Okoro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

(2016) Ira Tabas et al.   CIRCULATION RESEARCH

Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Anusha Kalbasi et al.   CLINICAL CANCER RESEARCH

HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance

(2016) Akiko Takikawa et al.   DIABETES

Glucose-6-Phosphate Dehydrogenase Deficiency Improves Insulin Resistance With Reduced Adipose Tissue Inflammation in Obesity

(2016) Mira Ham et al.   DIABETES

The role of AHR-inducible cytochrome P450s in metabolism of polyunsaturated fatty acids

(2016) Oliver Hankinson   DRUG METABOLISM REVIEWS

Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration

(2016) Tamas Varga et al.   IMMUNITY

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Energy metabolism in osteoclast formation and activity

(2016) Silvia Lemma et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly Dynamic Transcriptional Signature of Distinct Macrophage Subsets during Sterile Inflammation, Resolution, and Tissue Repair

(2016) Tamas Varga et al.   JOURNAL OF IMMUNOLOGY

Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation

(2016) Abigail S. Haka et al.   JOURNAL OF LIPID RESEARCH

Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment

(2016) Di Liu et al.   JOURNAL OF PROTEOME RESEARCH

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

(2016) Xiaochao Wei et al.   NATURE

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

(2016) Johan Garaude et al.   NATURE IMMUNOLOGY

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

(2016) Mireille Ouimet et al.   NATURE IMMUNOLOGY

Fatty acid oxidation in macrophage polarization

(2016) Mitsunori Nomura et al.   NATURE IMMUNOLOGY

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression

(2016) Christina Mertens et al.   PLoS One

Macrophage PI3K  Drives Pancreatic Ductal Adenocarcinoma Progression

(2016) M. M. Kaneda et al.   Cancer Discovery

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

(2016) Robert L. Bowman et al.   Cell Reports

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

Metabolic Regulation of Histone Post-Translational Modifications

(2015) Jing Fan et al.   ACS Chemical Biology

Increased expression of NAMPT in PBMC from patients with acute coronary syndrome and in inflammatory M1 macrophages

(2015) Bente Halvorsen et al.   ATHEROSCLEROSIS

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in AtherosclerosisNovelty and Significance

(2015) Denuja Karunakaran et al.   CIRCULATION RESEARCH

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

(2015) Johannes Meiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms

(2015) Rong Zeng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Myeloid HIFs Are Dispensable for Resolution of Inflammation during Skeletal Muscle Regeneration

(2015) Julien Gondin et al.   JOURNAL OF IMMUNOLOGY

Functions and development of red pulp macrophages

(2015) Daisuke Kurotaki et al.   MICROBIOLOGY AND IMMUNOLOGY

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

(2015) Fabienne Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overcoming inactivation of the lung surfactant by serum proteins: a potential role for fluorocarbons?

(2015) Marie Pierre Krafft   Soft Matter

Origin of Microglia: Current Concepts and Past Controversies

(2015) Florent Ginhoux et al.   Cold Spring Harbor Perspectives in Biology

Revisiting Mouse Peritoneal Macrophages: Heterogeneity, Development, and Function

(2015) Alexandra dos Anjos Cassado et al.   Frontiers in Immunology

Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status

(2015) Theresa Schöttl et al.   Molecular Metabolism

Reversal of Hypoxia in Murine Atherosclerosis Prevents Necrotic Core Expansion by Enhancing Efferocytosis

(2014) Elke Marsch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization

(2014) Dmitry Namgaladze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages

(2014) Malay Haldar et al.   CELL

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

Mechanisms of Plaque Formation and Rupture

(2014) Jacob Fog Bentzon et al.   CIRCULATION RESEARCH

Moderate Hypoxia Potentiates Interleukin-1β Production in Activated Human Macrophages

(2014) Eduardo J. Folco et al.   CIRCULATION RESEARCH

Macrophage HIF-2  Ameliorates Adipose Tissue Inflammation and Insulin Resistance in Obesity

(2014) S. S. Choe et al.   DIABETES

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival

(2014) Emmanuel L. Gautier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage

(2014) Atsushi Yamashita et al.   PLoS One

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

(2014) Takanobu Yamamoto et al.   PLoS One

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

(2014) M. Rosas et al.   SCIENCE

Testing the Role of Myeloid Cell Glucose Flux in Inflammation and Atherosclerosis

(2014) Tomohiro Nishizawa et al.   Cell Reports

Oxidative Stress in Malignant Melanoma Enhances Tumor Necrosis Factor-α Secretion of Tumor-Associated Macrophages That Promote Cancer Cell Invasion

(2013) Xuzhu Lin et al.   ANTIOXIDANTS & REDOX SIGNALING

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

(2013) Rémi Mounier et al.   Cell Metabolism

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function

(2013) Atsushi Nakamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloid Hypoxia-Inducible Factor-1  Is Essential for Skeletal Muscle Regeneration in Mice

(2013) N. Scheerer et al.   JOURNAL OF IMMUNOLOGY

Identification of a Tissue-Specific, C/EBP -Dependent Pathway of Differentiation for Murine Peritoneal Macrophages

(2013) D. W. Cain et al.   JOURNAL OF IMMUNOLOGY

Macrophage Glucose-6-Phosphate Dehydrogenase Stimulates Proinflammatory Responses with Oxidative Stress

(2013) M. Ham et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA 33 Regulates Glucose Metabolism

(2013) C. M. Ramirez et al.   MOLECULAR AND CELLULAR BIOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

The nuclear receptor LXRα controls the functional specialization of splenic macrophages

(2013) Noelia A-Gonzalez et al.   NATURE IMMUNOLOGY

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron laden macrophages in idiopathic pulmonary fibrosis: The telltale of occult alveolar hemorrhage?

(2013) Ermanno Puxeddu et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Role of Phospholipid Oxidation Products in Atherosclerosis

(2012) Sangderk Lee et al.   CIRCULATION RESEARCH

Activation of Sterol-response Element-binding Proteins (SREBP) in Alveolar Type II Cells Enhances Lipogenesis Causing Pulmonary Lipotoxicity

(2012) Laurent Plantier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCAAT/Enhancer-binding Protein β (C/EBPβ) Expression Regulates Dietary-induced Inflammation in Macrophages and Adipose Tissue in Mice

(2012) Shaikh M. Rahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

(2012) Janine M van Gils et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Regression of Atherosclerosis Is Characterized by Broad Changes in the Plaque Macrophage Transcriptome

(2012) Jonathan E. Feig et al.   PLoS One

The Distribution of Macrophages with a M1 or M2 Phenotype in Relation to Prognosis and the Molecular Characteristics of Colorectal Cancer

(2012) Sofia Edin et al.   PLoS One

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

Detection of High-Risk Atherosclerotic Plaque

(2012) Jerome L. Fleg et al.   JACC-Cardiovascular Imaging

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Macrophage Mal1 Deficiency Suppresses Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice by Activating Peroxisome Proliferator-Activated Receptor-γ–Regulated Genes

(2011) Vladimir R. Babaev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism

(2011) Sajesh Parathath et al.   CIRCULATION RESEARCH

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

(2011) Katey J. Rayner et al.   JOURNAL OF CLINICAL INVESTIGATION

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

(2011) A. Davalos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment

(2010) Carlo O. Martinez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution

(2010) G. Kovtunovych et al.   BLOOD

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI

(2010) Janice M.W. Taylor et al.   CARDIOVASCULAR RESEARCH

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

A Mouse Macrophage Lipidome

(2010) Edward A. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice

(2010) Pingping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

(2010) Jonathan E. Feig et al.   JOURNAL OF CLINICAL INVESTIGATION

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol

(2010) Xuewei Zhu et al.   JOURNAL OF LIPID RESEARCH

Targeted PPARγ deficiency in alveolar macrophages disrupts surfactant catabolism

(2010) Anna D. Baker et al.   JOURNAL OF LIPID RESEARCH

The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer

(2010) Qiang Zhou et al.   Journal of Translational Medicine

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Density Gene Expression Analysis of Tumor-Associated Macrophages from Mouse Mammary Tumors

(2009) Laureen S. Ojalvo et al.   AMERICAN JOURNAL OF PATHOLOGY

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

ATP-binding cassette transporter hallmarks tissue macrophages and modulates cytokine-triggered polarization programs

(2009) Lydie C. Pradel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

StAR Overexpression Decreases Serum and Tissue Lipids in Apolipoprotein E-deficient Mice

(2009) Yanxia Ning et al.   LIPIDS

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

(2008) Laurent Yvan-Charvet et al.   CIRCULATION

Increased Cellular Free Cholesterol in Macrophage-specificAbca1Knock-out Mice Enhances Pro-inflammatory Response of Macrophages

(2008) Xuewei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

(2008) Masako Kohyama et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE