Epigenetic Regulation of Kupffer Cell Function in Health and Disease
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Title
Epigenetic Regulation of Kupffer Cell Function in Health and Disease
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-01-26
DOI
10.3389/fimmu.2020.609618
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Note: Only part of the references are listed.- Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy
- (2020) Genaro Hernandez et al. Science Translational Medicine
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- (2020) Xiaobo Wang et al. Cell Metabolism
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- (2020) Hung-Yu Lin et al. Cells
- Abnormal liver function tests in COVID‐19 patients: relevance and potential pathogenesis
- (2020) Anna Bertolini et al. HEPATOLOGY
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- (2020) Camille Blériot et al. IMMUNITY
- Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis
- (2020) Sophie Tran et al. IMMUNITY
- Index and biological spectrum of human DNase I hypersensitive sites
- (2020) Wouter Meuleman et al. NATURE
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- (2020) Anneleen Remmerie et al. IMMUNITY
- The evolving metabolic landscape of chromatin biology and epigenetics
- (2020) Ziwei Dai et al. NATURE REVIEWS GENETICS
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- (2019) Ana Ramón-Vázquez et al. MOLECULAR AND CELLULAR BIOLOGY
- Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis
- (2019) Oliver Krenkel et al. GUT
- The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials
- (2019) Arun J. Sanyal et al. HEPATOLOGY
- Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology
- (2019) Sho Morioka et al. IMMUNITY
- Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner
- (2019) Diego Adhemar Jaitin et al. CELL
- The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
- (2019) Anthony Kusnadi et al. IMMUNITY
- Vitamin D receptor activation in liver macrophages protects against hepatic endoplasmic reticulum stress in mice
- (2019) Ying Zhou et al. HEPATOLOGY
- Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice
- (2019) Bingning Dong et al. HEPATOLOGY
- Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche
- (2019) Johnny Bonnardel et al. IMMUNITY
- Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development
- (2019) Juliette Mouries et al. JOURNAL OF HEPATOLOGY
- Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis
- (2019) Xuelian Xiong et al. MOLECULAR CELL
- YAP in Kupffer cells enhances the production of pro‐inflammatory cytokines and promotes the development of non‐alcoholic steatohepatitis
- (2019) Kyoungsub Song et al. HEPATOLOGY
- Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity
- (2019) Mashito Sakai et al. IMMUNITY
- Resolving the fibrotic niche of human liver cirrhosis at single-cell level
- (2019) P. Ramachandran et al. NATURE
- CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement
- (2019) Gongguan Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fungal dissemination is limited by liver macrophage filtration of the blood
- (2019) Donglei Sun et al. Nature Communications
- Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses
- (2019) Kathryn S Carpentier et al. eLife
- Increased liver localization of lipopolysaccharides in human and experimental non‐alcoholic fatty liver disease
- (2019) Guido Carpino et al. HEPATOLOGY
- NicheNet: modeling intercellular communication by linking ligands to target genes
- (2019) Robin Browaeys et al. NATURE METHODS
- Dynamic Ligand Discrimination in the Notch Signaling Pathway
- (2018) Nagarajan Nandagopal et al. CELL
- The role of Kupffer cells in hepatic iron and lipid metabolism
- (2018) Charlotte L. Scott et al. JOURNAL OF HEPATOLOGY
- Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
- (2018) Tamer Sallam et al. NATURE MEDICINE
- DNA methylation-based biomarkers and the epigenetic clock theory of ageing
- (2018) Steve Horvath et al. NATURE REVIEWS GENETICS
- Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages
- (2018) Evan D. Muse et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche
- (2018) Rumela Chakrabarti et al. SCIENCE
- Enhancer of zeste homolog 2-catalysed H3K27 trimethylation plays a key role in acute-on-chronic liver failure via TNF-mediated pathway
- (2018) Tianhui Zhou et al. Cell Death & Disease
- Dietary Lipids Differentially Shape NASH Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages
- (2018) Brett McGettigan et al. HEPATOLOGY
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- (2017) Biljana Atanasovska et al. HEPATOLOGY
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- (2017) Chris Estes et al. HEPATOLOGY
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- (2017) Auvro R. Mridha et al. JOURNAL OF HEPATOLOGY
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- (2017) Shashi Bala et al. JOURNAL OF LEUKOCYTE BIOLOGY
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- (2017) George N. Ioannou et al. JOURNAL OF LIPID RESEARCH
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- (2017) Fatjon Leti et al. Translational Research
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- (2015) Camille Blériot et al. IMMUNITY
- Genome-wide analysis of long noncoding RNA expression profiles in patients with non-alcoholic fatty liver disease
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- (2015) Tim Hendrikx et al. JOURNAL OF HEPATOLOGY
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- (2015) KUN HE et al. Molecular Medicine Reports
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- (2013) T. Fernandes-Alnemri et al. JOURNAL OF IMMUNOLOGY
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- (2013) Minna U. Kaikkonen et al. MOLECULAR CELL
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- (2013) Nelson C. Di Paolo et al. Cell Reports
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- (2012) Kouichi Miura et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
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- (2012) Ryan M. O'Connell et al. Annual Review of Immunology
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- (2012) Nathanael J. Spann et al. CELL
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- (2011) Andrew J Bannister et al. CELL RESEARCH
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- (2011) A. M. Deaton et al. GENOME RESEARCH
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- (2011) Elinore M. Mercer et al. IMMUNITY
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- (2011) Suzanne E. Mahady et al. JOURNAL OF HEPATOLOGY
- Molecular Mechanisms of Long Noncoding RNAs
- (2011) Kevin C. Wang et al. MOLECULAR CELL
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- (2010) Sven Heinz et al. MOLECULAR CELL
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
- (2010) Peter Duewell et al. NATURE
- The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
- (2010) Taro Kawai et al. NATURE IMMUNOLOGY
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- (2010) Gökhan S Hotamisligil NATURE MEDICINE
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- (2010) Vicky W. Zhou et al. NATURE REVIEWS GENETICS
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- (2010) Arun J. Sanyal et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2009) Nicolas Lanthier et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Critical role of Kupffer cells in the management of diet-induced diabetes and obesity
- (2009) Audrey M. Neyrinck et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
- (2009) W. Huang et al. DIABETES
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- (2009) Rinke Stienstra et al. HEPATOLOGY
- Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial
- (2009) Vlad Ratziu et al. HEPATOLOGY
- Inositol phosphatase SHIP1 is a primary target of miR-155
- (2009) R. M. O'Connell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LIVER X RECEPTOR AGONIST GW3965 DOSE-DEPENDENTLY REGULATES LPS-MEDIATED LIVER INJURY AND MODULATES POSTTRANSCRIPTIONAL TNF-α PRODUCTION AND P38 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION IN LIVER MACROPHAGES
- (2009) Yun Yong Wang et al. SHOCK
- Epigenetics, DNA Methylation, and Chromatin Modifying Drugs
- (2008) Moshe Szyf Annual Review of Pharmacology and Toxicology
- Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance
- (2008) Justin I. Odegaard et al. Cell Metabolism
- S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation
- (2008) Ainhoa Iglesias Ara et al. HEPATOLOGY
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