Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

Supramolecular Organization of Respiratory Complexes

(2016) José Antonio Enríquez   Annual Review of Physiology

The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency

(2016) Adela Guarás et al.   Cell Reports

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

(2016) Jan Naujoks et al.   PLoS Pathogens

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

(2015) Beth Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

(2015) Jing Geng et al.   NATURE IMMUNOLOGY

PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation

(2015) Anjali K. Nath et al.   Cell Reports

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use

(2014) Rebeca Acín-Pérez et al.   Cell Metabolism

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Toll-like Receptor Agonists Promote Prolonged Triglyceride Storage in Macrophages

(2013) Ying-ling Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

(2013) Anna Sokolovska et al.   NATURE IMMUNOLOGY

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

(2013) E. Lapuente-Brun et al.   SCIENCE

Changing appetites: the adaptive advantages of fuel choice

(2013) Illana A. Stanley et al.   TRENDS IN CELL BIOLOGY

Hypoxia attenuates inflammatory mediators production induced by Acanthamoeba via Toll-like receptor 4 signaling in human corneal epithelial cells

(2012) Hong Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues

(2012) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

(2011) Leif E. Sander et al.   NATURE

Oxygen radicals shaping evolution: Why fatty acid catabolism leads to peroxisomes while neurons do without it

(2010) Dave Speijer   BIOESSAYS

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cells Continue To Capture and Present Antigens after Maturation In Vivo

(2010) S. B. Drutman et al.   JOURNAL OF IMMUNOLOGY

Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System

(2009) Russell E. Vance et al.   Cell Host & Microbe

Functional dynamic compartmentalization of respiratory chain intermediate substrates: Implications for the control of energy production and mitochondrial diseases

(2008) G. Benard et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL