Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack

Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury

(2019) Alastair Mak et al.   Journal of Immunotoxicology

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis

(2019) Priya Handa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammation and Immunity: From an Adipocyte's Perspective

(2019) Calvin C. Chan et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

l-Arginine Synthesis from l-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo

(2019) Shannon M. Lange et al.   JOURNAL OF IMMUNOLOGY

Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner

(2019) Raphael Meier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crosstalk between adipose tissue insulin resistance and liver macrophages in Non Alcoholic Fatty Liver Disease

(2019) Chiara Rosso et al.   JOURNAL OF HEPATOLOGY

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

(2018) Scott L. Friedman et al.   HEPATOLOGY

Prediction of carotid intima-media thickness in obese patients with low prevalence of comorbidities by serum copper bioavailability

(2018) Giovanni Tarantino et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation

(2018) Nadine Gehrke et al.   JOURNAL OF HEPATOLOGY

Lipotoxicity and the gut-liver axis in NASH pathogenesis

(2018) Fabio Marra et al.   JOURNAL OF HEPATOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

(2018) Ludivine Laurans et al.   NATURE MEDICINE

Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice

(2018) Bodil Bjørndal et al.   Nutrition & Metabolism

Secretion of autoimmune antibodies in the human subcutaneous adipose tissue

(2018) Daniela Frasca et al.   PLoS One

Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease

(2018) Takashi Himoto et al.   Nutrients

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations

(2018) Roddy S. O’Connor et al.   Scientific Reports

Metabolic Modulation in Macrophage Effector Function

(2018) Ciana Diskin et al.   Frontiers in Immunology

Pentose Phosphate Shunt Modulates Reactive Oxygen Species and Nitric Oxide Production Controlling Trypanosoma cruzi in Macrophages

(2018) Sue-jie Koo et al.   Frontiers in Immunology

Macrophage-specific HIF-1α contributes to impaired autophagic flux in non-alcoholic steatohepatitis

(2018) Xiaojing Wang et al.   HEPATOLOGY

Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

(2017) Rohit Loomba et al.   HEPATOLOGY

Pivotal Role of TNF-α in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model

(2017) Satomi Kakino et al.   HORMONE AND METABOLIC RESEARCH

Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity

(2017) Anthony T. Phan et al.   IMMUNITY

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in non-alcoholic fatty liver disease

(2017) S Lefere et al.   INTERNATIONAL JOURNAL OF OBESITY

Current and future pharmacological therapies for NAFLD/NASH

(2017) Yoshio Sumida et al.   JOURNAL OF GASTROENTEROLOGY

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

(2017) Pi-Xiao Wang et al.   NATURE MEDICINE

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling

(2017) Daniel A Giles et al.   NATURE MEDICINE

Elucidating the Preadipocyte and Its Role in Adipocyte Formation: a Comprehensive Review

(2017) Christos N. Sarantopoulos et al.   Stem Cell Reviews and Reports

Clinical epidemiology and disease burden of nonalcoholic fatty liver disease

(2017) Brandon J Perumpail et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

(2017) So Yeon Kim et al.   Nature Communications

Elucidating the Preadipocyte and Its Role in Adipocyte Formation: a Comprehensive Review

(2017) Christos N. Sarantopoulos et al.   Stem Cell Reviews and Reports

Relevance of the NLRP3 Inflammasome in the Pathogenesis of Chronic Liver Disease

(2017) Xiaoqin Wu et al.   Frontiers in Immunology

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma

(2016) Ana L. Gomes et al.   CANCER CELL

Liver immunology and its role in inflammation and homeostasis

(2016) Mark W Robinson et al.   Cellular & Molecular Immunology

The end of the road for the tryptophan depletion concept in pregnancy and infection

(2016) A. A.- B. Badawy et al.   CLINICAL SCIENCE

Innate Immunity and Inflammation in NAFLD/NASH

(2016) Marco Arrese et al.   DIGESTIVE DISEASES AND SCIENCES

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy

(2016) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

Adiponectin: a versatile player of innate immunity

(2016) Yan Luo et al.   Journal of Molecular Cell Biology

The Role of IL-1 Family Members and Kupffer Cells in Liver Regeneration

(2016) Quanhui Tan et al.   Biomed Research International

Distinct Hepatic Macrophage Populations in Lean and Obese Mice

(2016) Rafael Mayoral Monibas et al.   Frontiers in Endocrinology

Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis

(2016) Daniel A. Giles et al.   PLoS One

Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction

(2016) Chikara Komiya et al.   PLoS One

Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation

(2016) Chang Liu et al.   Scientific Reports

CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis

(2016) Kyoko Tomita et al.   Scientific Reports

Experimental models of liver fibrosis

(2015) Sara Crespo Yanguas et al.   ARCHIVES OF TOXICOLOGY

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

(2015) Xiaoyan Hui et al.   Cell Metabolism

IL-17 Axis Driven Inflammation in Non-Alcoholic Fatty Liver Disease Progression

(2015) Daniel Giles et al.   CURRENT DRUG TARGETS

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Arginase 2 deficiency results in spontaneous steatohepatitis: A novel link between innate immune activation and hepatic de novo lipogenesis

(2015) Laura A. Navarro et al.   JOURNAL OF HEPATOLOGY

Differential Requirements for l-Citrulline and l-Arginine during Antimycobacterial Macrophage Activity

(2015) Shannon M. Rapovy et al.   JOURNAL OF IMMUNOLOGY

Increased NOD1, but not NOD2, activity in subcutaneous adipose tissue from patients with metabolic syndrome

(2015) Yi-Jun Zhou et al.   Obesity

The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease

(2015) Alexandra Feldman et al.   Biomed Research International

Role of NADPH oxidases in the redox biology of liver fibrosis

(2015) Eva Crosas-Molist et al.   Redox Biology

Effect of tryptophan supplementation on diet-induced non-alcoholic fatty liver disease in mice

(2014) Yvonne Ritze et al.   BRITISH JOURNAL OF NUTRITION

Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses

(2014) Dmitry Namgaladze et al.   DIABETOLOGIA

Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+macrophage infiltration in mice

(2014) Christer Baeck et al.   HEPATOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

(2014) Rodolfo Gómez et al.   Nature Reviews Rheumatology

IL-1 Signaling in Obesity-Induced Hepatic Lipogenesis and Steatosis

(2014) Kimberly A. Negrin et al.   PLoS One

Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas

(2014) M. A. Duque-Correa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease

(2014) Kouichi Miura   WORLD JOURNAL OF GASTROENTEROLOGY

IL-37 protects against obesity-induced inflammation and insulin resistance

(2014) Dov B. Ballak et al.   Nature Communications

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice

(2013) Isaac T.W. Harley et al.   HEPATOLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms

(2013) J. T. Mattila et al.   JOURNAL OF IMMUNOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

(2013) Luke Barron et al.   PLoS One

Effects of Indoleamine 2,3-Dioxygenase Deficiency on High-Fat Diet-Induced Hepatic Inflammation

(2013) Junji Nagano et al.   PLoS One

Fat Depots, Free Fatty Acids, and Dyslipidemia

(2013) Jon Ebbert et al.   Nutrients

Adipokines Mediate Inflammation and Insulin Resistance

(2013) Hyokjoon Kwon et al.   Frontiers in Endocrinology

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone

(2012) Isabelle Wolowczuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1

(2012) Joseph E. Qualls et al.   Cell Host & Microbe

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

NOD1 activation induces innate immune responses and insulin resistance in human adipocytes

(2012) Y.-J. Zhou et al.   DIABETES & METABOLISM

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity

(2012) Tracy L. McGaha et al.   IMMUNOLOGICAL REVIEWS

Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis

(2012) Laura J Dixon et al.   LABORATORY INVESTIGATION

Sinusoidal Endothelial Dysfunction Precedes Inflammation and Fibrosis in a Model of NAFLD

(2012) Marcos Pasarín et al.   PLoS One

Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice

(2012) Ahmed Al-Dwairi et al.   PLoS One

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of cytokines and chemokines in non-alcoholic fatty liver disease

(2012) Vincent Braunersreuther   WORLD JOURNAL OF GASTROENTEROLOGY

Progressive Endoplasmic Reticulum Stress Contributes to Hepatocarcinogenesis in Fatty Acyl-CoA Oxidase 1–Deficient Mice

(2011) Jiansheng Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells

(2011) R. W. O’Rourke et al.   DIABETOLOGIA

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice

(2011) Felix Heymann et al.   HEPATOLOGY

C-C Chemokine Receptor 2 Inhibitor Improves Diet-Induced Development of Insulin Resistance and Hepatic Steatosis in Mice

(2011) Yukinori Tamura et al.   Journal of Atherosclerosis and Thrombosis

Requirement of argininosuccinate lyase for systemic nitric oxide production

(2011) Ayelet Erez et al.   NATURE MEDICINE

Lampe1: An ENU-Germline Mutation Causing Spontaneous Hepatosteatosis Identified through Targeted Exon-Enrichment and Next-Generation Sequencing

(2011) Rachel Sheridan et al.   PLoS One

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

(2010) Lisa S. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

(2010) A. E. Obstfeld et al.   DIABETES

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis

(2010) Rohit Kohli et al.   HEPATOLOGY

Control of immune response by amino acid metabolism

(2010) Ursula Grohmann et al.   IMMUNOLOGICAL REVIEWS

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

(2010) Marie-Luise Berres et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of fat specific protein 27 by isoproterenol and TNF-α to control lipolysis in murine adipocytes

(2010) Srijana Ranjit et al.   JOURNAL OF LIPID RESEARCH

Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice

(2010) Kanji Yamaguchi et al.   LABORATORY INVESTIGATION

Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes

(2010) Josef Ecker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemokines in Liver Inflammation and Fibrosis

(2010) Hermann Wasmuth et al.   SEMINARS IN LIVER DISEASE

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications

(2009) Elisa Fabbrini et al.   HEPATOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

CCR1 and CCR5 promote hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   JOURNAL OF CLINICAL INVESTIGATION

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

Innate Immunity and Adipocyte Function: Ligand-specific Activation of Multiple Toll-like Receptors Modulates Cytokine, Adipokine, and Chemokine Secretion in Adipocytes

(2009) Andrea Kopp et al.   Obesity

IL-6 Deficiency Attenuates Murine Diet-Induced Non-Alcoholic Steatohepatitis

(2009) Emmanuel Mas et al.   PLoS One

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Copper Availability Contributes to Iron Perturbations in Human Nonalcoholic Fatty Liver Disease

(2008) Elmar Aigner et al.   GASTROENTEROLOGY

Liver Myofibroblasts Regulate Infiltration and Positioning of Lymphocytes in Human Liver

(2008) Andrew P. Holt et al.   GASTROENTEROLOGY

Olmesartan Prevents Cardiovascular Injury and Hepatic Steatosis in Obesity and Diabetes, Accompanied by Apoptosis Signal Regulating Kinase-1 Inhibition

(2008) Eiichiro Yamamoto et al.   HYPERTENSION

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipocytokines and liver disease

(2008) Yoshihiro Kamada et al.   JOURNAL OF GASTROENTEROLOGY

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

(2008) Karim C El Kasmi et al.   NATURE IMMUNOLOGY

Diagnosis of Nonalcoholic Fatty Liver Disease: Invasive versus Noninvasive

(2008) Anna Wieckowska et al.   SEMINARS IN LIVER DISEASE

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR