Origin and ontogeny of lung macrophages: from mice to humans

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Pulmonary alveolar proteinosis

(2019) Bruce C. Trapnell et al.   Nature Reviews Disease Primers

Gut microbiota in HIV–pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction

(2019) Meera K. Shenoy et al.   Microbiome

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

(2019) Ilias Angelidis et al.   Nature Communications

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

(2019) Svetoslav Chakarov et al.   SCIENCE

A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation

(2019) Carlos M. Minutti et al.   IMMUNITY

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

A cellular census of human lungs identifies novel cell states in health and in asthma

(2019) Felipe A. Vieira Braga et al.   NATURE MEDICINE

Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

(2019) Zhaoyuan Liu et al.   CELL

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self‐renewal and identity

(2019) René Rauschmeier et al.   EMBO JOURNAL

The influence of the microbiome on respiratory health

(2019) Tomasz P. Wypych et al.   NATURE IMMUNOLOGY

Human macrophages and innate lymphoid cells: Tissue-resident innate immunity in humanized mice

(2019) Arlisa Alisjahbana et al.   BIOCHEMICAL PHARMACOLOGY

Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis

(2018) Alexandra L. McCubbrey et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity

(2018) Maude Liegeois et al.   CELLULAR IMMUNOLOGY

Niche signals and transcription factors involved in tissue-resident macrophage development

(2018) Wouter T'Jonck et al.   CELLULAR IMMUNOLOGY

Alveolar Macrophages

(2018) Nikita Joshi et al.   CELLULAR IMMUNOLOGY

Dietary Fiber Confers Protection against Flu by Shaping Ly6c − Patrolling Monocyte Hematopoiesis and CD8 + T Cell Metabolism

(2018) Aurélien Trompette et al.   IMMUNITY

Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung

(2018) Stéphane Mouraux et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Growth ofMycobacterium tuberculosisin vivo segregates with host macrophage metabolism and ontogeny

(2018) Lu Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-36γ Protects against Severe Influenza Infection by Promoting Lung Alveolar Macrophage Survival and Limiting Viral Replication

(2018) Alexander N. Wein et al.   JOURNAL OF IMMUNOLOGY

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Lung Interstitial Macrophages: Past, Present, and Future

(2018) Joey Schyns et al.   Journal of Immunology Research

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function

(2018) Helena M. Izquierdo et al.   Cell Reports

Modulation of Pulmonary Microbiota by Antibiotic or Probiotic Aerosol Therapy: A Strategy to Promote Immunosurveillance against Lung Metastases

(2018) Valentino Le Noci et al.   Cell Reports

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

(2018) Yushi Yao et al.   CELL

Early-Life Formation of the Microbial and Immunological Environment of the Human Airways

(2018) Céline Pattaroni et al.   Cell Host & Microbe

Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages

(2017) Catherine Sabatel et al.   IMMUNITY

TGF-β Gives an Air of Exclusivity to Alveolar Macrophages

(2017) Bart N. Lambrecht   IMMUNITY

The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

(2017) Xueyang Yu et al.   IMMUNITY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice

(2017) Christine K. Wong et al.   JOURNAL OF IMMUNOLOGY

Location, function, and ontogeny of pulmonary macrophages during the steady state

(2017) Natalio Garbi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

The microbiota protects against respiratory infection via GM-CSF signaling

(2017) Rebecca L. Brown et al.   Nature Communications

Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia

(2017) Petra Um-Bergström et al.   BMC Pulmonary Medicine

Human Lung Mononuclear Phagocytes in Health and Disease

(2017) Faezzah Baharom et al.   Frontiers in Immunology

Airway Microbiota Determines Innate Cell Inflammatory or Tissue Remodeling Profiles in Lung Transplantation

(2016) Eric Bernasconi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes

(2016) A. Nicole Desch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice

(2016) Ankit Bharat et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues

(2016) Yen-Rei A. Yu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Long-Term Persistence of Donor Alveolar Macrophages in Human Lung Transplant Recipients That Influences Donor-Specific Immune Responses

(2016) D. K. Nayak et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Advanced Age Alters Monocyte and Macrophage Responses

(2016) Joslyn M. Albright et al.   ANTIOXIDANTS & REDOX SIGNALING

Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice

(2016) Y. Saito et al.   BLOOD

Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli

(2016) E. M. Todd et al.   BLOOD

Lung surfactant metabolism: early in life, early in disease and target in cell therapy

(2016) Elena Lopez-Rodriguez et al.   CELL AND TISSUE RESEARCH

Developmental origin of lung macrophage diversity

(2016) Serena Y. S. Tan et al.   DEVELOPMENT

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Dendritic Cells and Monocytes with Distinct Inflammatory Responses Reside in Lung Mucosa of Healthy Humans

(2016) Faezzah Baharom et al.   JOURNAL OF IMMUNOLOGY

Transcriptional Classification and Functional Characterization of Human Airway Macrophage and Dendritic Cell Subsets

(2016) Vineet I. Patel et al.   JOURNAL OF IMMUNOLOGY

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

The development and maintenance of resident macrophages

(2016) Elisa Gomez Perdiguero et al.   NATURE IMMUNOLOGY

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

(2016) E. L. Soucie et al.   SCIENCE

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

Long-term persistence of human donor alveolar macrophages in lung transplant recipients

(2016) Ibon Eguíluz-Gracia et al.   THORAX

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages

(2015) S. L. Gibbings et al.   BLOOD

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Blood Monocytes and Their Subsets: Established Features and Open Questions

(2015) Loems Ziegler-Heitbrock   Frontiers in Immunology

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Epithelial  1 integrin is required for lung branching morphogenesis and alveolarization

(2014) E. J. Plosa et al.   DEVELOPMENT

Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity

(2014) Christina Purnama et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Tissue macrophage identity and self-renewal

(2014) Rebecca Gentek et al.   IMMUNOLOGICAL REVIEWS

In Vivo Characterization of Alveolar and Interstitial Lung Macrophages in Rhesus Macaques: Implications for Understanding Lung Disease in Humans

(2014) Y. Cai et al.   JOURNAL OF IMMUNOLOGY

Characterization of lung inflammation and its impact on macrophage function in aging

(2014) Cynthia H. Canan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice

(2014) K. A. Sauter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

(2014) Kristin Westphalen et al.   NATURE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Characterization of the Inflammatory Infiltrate in Streptococcus pneumoniae Pneumonia in Young and Elderly Patients

(2014) Thomas Menter et al.   PATHOBIOLOGY

Macrophage Phenotype Is Associated with Disease Severity in Preterm Infants with Chronic Lung Disease

(2014) Lynne R. Prince et al.   PLoS One

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection

(2014) Christoph Schneider et al.   PLoS Pathogens

The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma

(2013) Elena Goleva et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

(2013) Anthony Rongvaux et al.   Annual Review of Immunology

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections

(2013) H. E. Ghoneim et al.   JOURNAL OF IMMUNOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Beyond Stem Cells: Self-Renewal of Differentiated Macrophages

(2013) M. H. Sieweke et al.   SCIENCE

Intranasal priming of newborn mice with microbial extracts increases opsonic factors and mature CD11c+ cells in the airway

(2012) Kazuki Kasahara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Alveolar Macrophages in Neonatal Mice Are Inherently Unresponsive to Pneumocystis murina Infection

(2012) Cathryn Kurkjian et al.   INFECTION AND IMMUNITY

Systemic Analysis of PPAR  in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity

(2012) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury

(2011) William J Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

NF- B Signaling in Fetal Lung Macrophages Disrupts Airway Morphogenesis

(2011) T. S. Blackwell et al.   JOURNAL OF IMMUNOLOGY

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

(2011) T. Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement

(2011) Tim Willinger et al.   TRENDS IN IMMUNOLOGY

Targeted PPARγ deficiency in alveolar macrophages disrupts surfactant catabolism

(2010) Anna D. Baker et al.   JOURNAL OF LIPID RESEARCH

Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network

(2010) B. J. Stoll et al.   PEDIATRICS

Human GM-CSF Autoantibodies and Reproduction of Pulmonary Alveolar Proteinosis

(2009) Takuro Sakagami et al.   NEW ENGLAND JOURNAL OF MEDICINE

MafB/c-Maf Deficiency Enables Self-Renewal of Differentiated Functional Macrophages

(2009) A. Aziz et al.   SCIENCE

The Prolonged Life-Span of Alveolar Macrophages

(2008) Jaime Murphy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Familial pulmonary alveolar proteinosis caused by mutations inCSF2RA

(2008) Takuji Suzuki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRα gene in the X chromosome pseudoautosomal region 1

(2008) Margarita Martinez-Moczygemba et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection

(2008) Keer Sun et al.   NATURE MEDICINE

Chest radiograph thoracic areas and lung volumes in infants developing bronchopulmonary dysplasia

(2008) Caroline May et al.   PEDIATRIC PULMONOLOGY