Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue

Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism

(2018) Vlad Serbulea et al.   Molecular Metabolism

The effect of oxidized phospholipids on phenotypic polarization and function of macrophages

(2017) Vlad Serbulea et al.   FREE RADICAL BIOLOGY AND MEDICINE

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

(2017) Ivan Zanoni et al.   IMMUNITY

Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moietyin vitroandin vivo: Implication in atherosclerosis

(2017) Jianhong Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in HumansClinical Perspective

(2016) Fleur M. van der Valk et al.   CIRCULATION

Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation

(2016) Samantha E. Adamson et al.   JOURNAL OF CLINICAL INVESTIGATION

Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2

(2016) Akira Abe et al.   JOURNAL OF LIPID RESEARCH

Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials

(2016) Nicholas J Viney et al.   LANCET

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus

(2015) Angelo Y. Meliton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oxidative Lipidomics Coming of Age: Advances in Analysis of Oxidized Phospholipids in Physiology and Pathology

(2015) Corinne M. Spickett et al.   ANTIOXIDANTS & REDOX SIGNALING

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study

(2015) Sotirios Tsimikas et al.   LANCET

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

The Adipocyte-Inducible Secreted Phospholipases PLA2G5 and PLA2G2E Play Distinct Roles in Obesity

(2014) Hiroyasu Sato et al.   Cell Metabolism

Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids

(2014) Sean S. Davies et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Oxidative Stress and Obesity: The Chicken or the Egg?

(2014) A. R. Aroor et al.   DIABETES

Discovery of a Highly Potent Anti-inflammatory Epoxyisoprostane-Derived Lactone

(2014) Julian Egger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Synthesis of Epoxyisoprostanes: Effects in Reducing Secretion of Pro-inflammatory Cytokines IL-6 and IL-12

(2013) Julian Egger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution

(2013) J. S. Orr et al.   DIABETES

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes and neutrophils and the oxidative burst from human blood

(2013) Balu K Chacko et al.   LABORATORY INVESTIGATION

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

(2013) Brandon M. Kenwood et al.   Molecular Metabolism

Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation

(2012) Isabel Gonçalves et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protein modification by aldehydophospholipids and its functional consequences

(2012) Ute Stemmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural Identification and Cardiovascular Activities of Oxidized Phospholipids

(2012) Robert G. Salomon   CIRCULATION RESEARCH

A simplified procedure for semi-targeted lipidomic analysis of oxidized phosphatidylcholines induced by UVA irradiation

(2012) Florian Gruber et al.   JOURNAL OF LIPID RESEARCH

Mass spectrometry analysis of oxidized phosphatidylcholine and phosphatidylethanolamine

(2011) Valerie B. O'Donnell   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

Isoprostane Generation and Function

(2011) Ginger L. Milne et al.   CHEMICAL REVIEWS

Aberrant Accumulation of Undifferentiated Myeloid Cells in the Adipose Tissue of CCR2-Deficient Mice Delays Improvements in Insulin Sensitivity

(2011) Dario A. Gutierrez et al.   DIABETES

Identification of oxidized phospholipids by electrospray ionization mass spectrometry and LC–MS using a QQLIT instrument

(2011) Corinne M. Spickett et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2

(2011) Alexandra Kadl et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress Accumulates in Adipose Tissue during Aging and Inhibits Adipogenesis

(2011) Hannes M. Findeisen et al.   PLoS One

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection

(2010) S. R. Clark et al.   BLOOD

Lysophosphatidylcholine is Generated by Spontaneous Deacylation of Oxidized Phospholipids

(2010) Jaewoo Choi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

(2010) Alexandra Kadl et al.   CIRCULATION RESEARCH

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species

(2010) Brian P. Dranka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression

(2010) M Zeyda et al.   INTERNATIONAL JOURNAL OF OBESITY

Phospholipid-esterified Eicosanoids Are Generated in Agonist-activated Human Platelets and Enhance Tissue Factor-dependent Thrombin Generation

(2010) Christopher P. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice

(2010) Pingping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidized Phospholipids Are More Potent Antagonists of Lipopolysaccharide than Inducers of Inflammation

(2010) O. V. Oskolkova et al.   JOURNAL OF IMMUNOLOGY

Adipose tissue macrophages: their role in adipose tissue remodeling

(2010) Takayoshi Suganami et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Generation and Biological Activities of Oxidized Phospholipids

(2009) Valery N. Bochkov et al.   ANTIOXIDANTS & REDOX SIGNALING

PPAR γ is highly expressed in F4/80hi adipose tissue macrophages and dampens adipose-tissue inflammation

(2009) Josep Bassaganya-Riera et al.   CELLULAR IMMUNOLOGY

Role of macrophage tissue infiltration in obesity and insulin resistance

(2009) V. Bourlier et al.   DIABETES & METABOLISM

Multi-Hit Inhibition of Circulating and Cell-Associated Components of the Toll-Like Receptor 4 Pathway by Oxidized Phospholipids

(2008) Elena von Schlieffen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity

(2008) Leonie Heilbronn et al.   CURRENT PHARMACEUTICAL DESIGN

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Oxidation-specific epitopes are important targets of innate immunity

(2008) M.-Y. Chou et al.   JOURNAL OF INTERNAL MEDICINE