Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium

(2016) Hiroe Toba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes

(2016) A. Nicole Desch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice

(2016) Ankit Bharat et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues

(2016) Yen-Rei A. Yu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Long-Term Persistence of Donor Alveolar Macrophages in Human Lung Transplant Recipients That Influences Donor-Specific Immune Responses

(2016) D. K. Nayak et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Abandoning M1/M2 for a Network Model of Macrophage Function

(2016) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity

(2016) Romina Fiorotto et al.   HEPATOLOGY

Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis

(2016) Jennifer L. Larson-Casey et al.   IMMUNITY

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

(2016) Katerina Vlantis et al.   IMMUNITY

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Genetic and clinical data reinforce the role of GAS6 and TAM receptors in liver fibrosis

(2016) Montserrat Marí et al.   JOURNAL OF HEPATOLOGY

Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis

(2016) Yanli Yan et al.   KIDNEY INTERNATIONAL

Matrix metalloproteinase 12 is an indicator of intervertebral disc degeneration co-expressed with fibrotic markers

(2016) F.-J. Lv et al.   OSTEOARTHRITIS AND CARTILAGE

Deletion of Apoptosis Inhibitor of Macrophage (AIM)/CD5L Attenuates the Inflammatory Response and Infarct Size in Acute Myocardial Infarction

(2016) Toshiyuki Nishikido et al.   Journal of the American Heart Association

Lung-Specific Loss of α3 Laminin Worsens Bleomycin-Induced Pulmonary Fibrosis

(2015) Luisa I. Morales-Nebreda et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Functional Gene Networks: R/Bioc package to generate and analyse gene networks derived from functional enrichment and clustering

(2015) Sara Aibar et al.   BIOINFORMATICS

Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages

(2015) S. L. Gibbings et al.   BLOOD

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2015) Franziska Paul et al.   CELL

VCAM-1 is a TGF-β1 inducible gene upregulated in idiopathic pulmonary fibrosis

(2015) Marianna Agassandian et al.   CELLULAR SIGNALLING

Mice overexpressing integrin αv in fibroblasts exhibit dermal thinning of the skin

(2015) Zhongzhi Wang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells

(2015) T. Y. Brodeur et al.   JOURNAL OF IMMUNOLOGY

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner

(2015) Carla M. Cuda et al.   ARTHRITIS RESEARCH & THERAPY

P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy

(2015) Anthony Sinadinos et al.   PLOS MEDICINE

Protein Tyrosine Phosphatase α Mediates Profibrotic Signaling in Lung Fibroblasts through TGF-β Responsiveness

(2014) Yael Aschner et al.   AMERICAN JOURNAL OF PATHOLOGY

Wnt CoreceptorLrp5Is a Driver of Idiopathic Pulmonary Fibrosis

(2014) Anna P. Lam et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

C-X-C Motif Chemokine 13 (CXCL13) Is a Prognostic Biomarker of Idiopathic Pulmonary Fibrosis

(2014) Louis J. Vuga et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of Growth Arrest–Specific Gene 6 in the Development of Fungal Allergic Airway Disease in Mice

(2014) Takehiko Shibata et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction

(2014) Dong Fan et al.   CARDIOVASCULAR RESEARCH

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair

(2014) Kenta Moriwaki et al.   IMMUNITY

Mononuclear phagocytes of the intestine, the skin, and the lung

(2014) Charlotte L. Scott et al.   IMMUNOLOGICAL REVIEWS

Caspase-8 Acts as a Molecular Rheostat To Limit RIPK1- and MyD88-Mediated Dendritic Cell Activation

(2014) C. M. Cuda et al.   JOURNAL OF IMMUNOLOGY

Cathepsin B contributes to Na+hyperabsorption in cystic fibrosis airway epithelial cultures

(2014) Chong Da Tan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury

(2014) Luisa Morales-Nebreda et al.   JOURNAL OF VIROLOGICAL METHODS

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Chitinase 3-Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis

(2014) Y. Zhou et al.   Science Translational Medicine

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Necroptotic signaling in adaptive and innate immunity

(2014) Jennifer V. Lu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Functions of caspase 8: The identified and the mysterious

(2014) Guy S. Salvesen et al.   SEMINARS IN IMMUNOLOGY

Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice

(2014) Alexander V. Misharin et al.   Cell Reports

Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung

(2013) Alexander V. Misharin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Protective effects of matrix metalloproteinase-12 following corneal injury

(2013) M. F. Chan et al.   JOURNAL OF CELL SCIENCE

Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function

(2013) Atsushi Nakamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Busulfan Administration Flexibility Increases the Applicability of Scid Repopulating Cell Assay in NSG Mouse Model

(2013) Jean Chevaleyre et al.   PLoS One

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Ly6ChiMonocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

(2011) Michael A. Gibbons et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury

(2011) William J Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Functional Analysis beyond Enrichment: Non-Redundant Reciprocal Linkage of Genes and Biological Terms

(2011) Celia Fontanillo et al.   PLoS One

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis

(2010) Amber L. Degryse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis

(2010) Nicolas Riteau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Loss of Matrix Metalloproteinase-13 Attenuates Murine Radiation-Induced Pulmonary Fibrosis

(2010) Paul Flechsig et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

(2010) Hisako Ishizuka et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases and Attenuates IL-13-Dependent Fibrosis

(2010) S. K. Madala et al.   JOURNAL OF IMMUNOLOGY

Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages

(2010) Lynne A. Murray et al.   PLoS One

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Gelsolin Regulates Cardiac Remodeling After Myocardial Infarction Through DNase I–Mediated Apoptosis

(2009) Guo Hua Li et al.   CIRCULATION RESEARCH

CD38-mediated Ca2+Signaling Contributes to Angiotensin II-induced Activation of Hepatic Stellate Cells

(2009) Seon-Young Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCR1 and CCR5 promote hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   JOURNAL OF CLINICAL INVESTIGATION

BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention

(2009) J Hutcheson et al.   ONCOGENE

Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels

(2009) I. Grgic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA