Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses

(2015) Marielle S. Köberlin et al.   CELL

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

(2015) Jong-Seok Moon et al.   JOURNAL OF CLINICAL INVESTIGATION

Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

(2015) Y. Zhou et al.   SCIENCE

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish

(2014) Paulina Ciepla et al.   Chemical Science

Insulin-Regulated Protein Palmitoylation Impacts Endothelial Cell Function

(2013) Xiaochao Wei et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blood spotlight on leukocytes and obesity

(2013) J. B. C. Carvalheira et al.   BLOOD

Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling

(2013) Katsuhiko Funai et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages, fat, and the emergence of immunometabolism

(2013) Anthony W. Ferrante   JOURNAL OF CLINICAL INVESTIGATION

Active Remodeling of Cortical Actin Regulates Spatiotemporal Organization of Cell Surface Molecules

(2012) Kripa Gowrishankar et al.   CELL

Fatty Acid Synthase Modulates Intestinal Barrier Function through Palmitoylation of Mucin 2

(2012) Xiaochao Wei et al.   Cell Host & Microbe

Elucidating membrane structure and protein behavior using giant plasma membrane vesicles

(2012) Erdinc Sezgin et al.   Nature Protocols

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

(2011) Ryan G. Holzer et al.   CELL

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma

(2011) Xuntian Jiang et al.   JOURNAL OF LIPID RESEARCH

Large-scale phosphosite quantification in tissues by a spike-in SILAC method

(2011) Mara Monetti et al.   NATURE METHODS

Quantitative imaging of membrane lipid order in cells and organisms

(2011) Dylan M Owen et al.   Nature Protocols

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

(2011) M. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Raft domains of variable properties and compositions in plasma membrane vesicles

(2011) I. Levental et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

De NovoLipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation

(2010) Xiaochao Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Fatty-acid Synthase Deficiency Decreases Diet-induced Atherosclerosis

(2010) Jochen G. Schneider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Super-SILAC mix for quantitative proteomics of human tumor tissue

(2010) Tamar Geiger et al.   NATURE METHODS

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Cholesterol-dependent phase separation in cell-derived giant plasma-membrane vesicles

(2009) Ilya Levental et al.   BIOCHEMICAL JOURNAL

Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver

(2009) Manu V. Chakravarthy et al.   CELL

Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol

(2009) Yvonne Lange et al.   JOURNAL OF LIPID RESEARCH

The Crystal Structure of a Mammalian Fatty Acid Synthase

(2008) T. Maier et al.   SCIENCE