Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

(2020) Arif Yurdagul et al.   Cell Metabolism

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

(2019) Alex J. Freemerman et al.   JOURNAL OF IMMUNOLOGY

Malonylation of GAPDH is an inflammatory signal in macrophages

(2019) Silvia Galván-Peña et al.   Nature Communications

Serine Metabolism Supports Macrophage IL-1β Production

(2019) Arianne E. Rodriguez et al.   Cell Metabolism

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

(2019) Daniel F J Ketelhuth et al.   CARDIOVASCULAR RESEARCH

Frontline Science: Acyl‐CoA synthetase 1 exacerbates lipotoxic inflammasome activation in primary macrophages

(2019) Gowri Kalugotla et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D

(2019) Arpita Basu et al.   JOURNAL OF LIPID RESEARCH

Atherosclerosis Imaging Using Positron Emission Tomography (PET): Insights and Applications

(2019) Rouchelle S. Sriranjan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes

(2019) Jenny E. Kanter et al.   JOURNAL OF CLINICAL INVESTIGATION

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

(2019) David P. De Souza et al.   JOURNAL OF CLINICAL INVESTIGATION

One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

(2019) Weiwei Yu et al.   MOLECULAR CELL

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses

(2019) P. Kent Langston et al.   NATURE IMMUNOLOGY

Apolipoprotein AI) Promotes Atherosclerosis Regression in Diabetic Mice by Suppressing Myelopoiesis and Plaque Inflammation

(2019) Tessa J. Barrett et al.   CIRCULATION

Biology and therapeutic potential of interleukin-10

(2019) Margarida Saraiva et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

(2019) Marco Di Gioia et al.   NATURE IMMUNOLOGY

Single-cell immune landscape of human atherosclerotic plaques

(2019) Dawn M. Fernandez et al.   NATURE MEDICINE

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity

(2019) Mario Ruiz et al.   eLife

Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense

(2019) Gabriela Krejčová et al.   eLife

Resolution metabolomes activated by hypoxic environment

(2019) Paul C. Norris et al.   Science Advances

Functional Characterization of LIPA (Lysosomal Acid Lipase) Variants Associated With Coronary Artery Disease

(2019) Trent D. Evans et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses

(2019) Yiliang Chen et al.   CIRCULATION RESEARCH

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

(2018) Ajit S. Divakaruni et al.   Cell Metabolism

Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases CCR7 Expression in Plaque Macrophages

(2018) Paul A. Mueller et al.   CIRCULATION

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine AtherosclerosisNovelty and Significance

(2018) Clément Cochain et al.   CIRCULATION RESEARCH

Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol ProductionNovelty and Significance

(2018) Manon Viaud et al.   CIRCULATION RESEARCH

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass CytometryNovelty and Significance

(2018) Holger Winkels et al.   CIRCULATION RESEARCH

Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques

(2018) Lukas Tomas et al.   EUROPEAN HEART JOURNAL

An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation

(2018) Richard G. Carroll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of non-resolving inflammation in atherosclerosis

(2018) Canan Kasikara et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of macrophage immunometabolism in atherosclerosis

(2018) Graeme J. Koelwyn et al.   NATURE IMMUNOLOGY

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

(2018) Feilong Wang et al.   Cell Metabolism

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment?

(2018) Jan Van den Bossche et al.   Cell Metabolism

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

(2018) Kyeongdae Kim et al.   CIRCULATION RESEARCH

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Spatially resolved metabolomics to discover tumor-associated metabolic alterations

(2018) Chenglong Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

(2018) Jeroen Baardman et al.   Cell Reports

Bempedoic acid

(2018) Amy C. Burke et al.   CURRENT OPINION IN LIPIDOLOGY

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

Metabolic regulation of NLRP3

(2017) Mark M. Hughes et al.   IMMUNOLOGICAL REVIEWS

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

(2017) Karishma Rahman et al.   JOURNAL OF CLINICAL INVESTIGATION

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

(2017) Dana M. Hardbower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

(2017) Xunde Xian et al.   eLife

Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of AtherosclerosisHighlights

(2016) Annemarie Aarup et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis

(2016) MacRae F. Linton et al.   CIRCULATION JOURNAL

Disruption of Glut1 in Hematopoietic Stem Cells Prevents Myelopoiesis and Enhanced Glucose Flux in Atheromatous Plaques ofApoE−/−MiceNovelty and Significance

(2016) Vincent Sarrazy et al.   CIRCULATION RESEARCH

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

(2016) Ira Tabas et al.   CIRCULATION RESEARCH

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

(2016) Xiaochao Wei et al.   NATURE

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Intermediates of Metabolism: From Bystanders to Signalling Molecules

(2016) Robert Haas et al.   TRENDS IN BIOCHEMICAL SCIENCES

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

(2016) Min Xie et al.   Nature Communications

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

HIF-1  and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages

(2015) A. Tawakol et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SnapShot: Immunometabolism

(2015) Peter J. Murray et al.   Cell Metabolism

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

A Broken Krebs Cycle in Macrophages

(2015) Luke A.J. O’Neill   IMMUNITY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1

(2015) Aaron M. Fond et al.   JOURNAL OF CLINICAL INVESTIGATION

Maintenance of Macrophage Redox Status by ChREBP Limits Inflammation and Apoptosis and Protects against Advanced Atherosclerotic Lesion Formation

(2015) Vincent Sarrazy et al.   Cell Reports

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice

(2015) Florian Willecke et al.   PLoS One

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Reversal of Hypoxia in Murine Atherosclerosis Prevents Necrotic Core Expansion by Enhancing Efferocytosis

(2014) Elke Marsch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

(2014) Anna Stincone et al.   BIOLOGICAL REVIEWS

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage

(2014) Atsushi Yamashita et al.   PLoS One

Testing the Role of Myeloid Cell Glucose Flux in Inflammation and Atherosclerosis

(2014) Tomohiro Nishizawa et al.   Cell Reports

Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-κB–Mediated Inflammation in Macrophages

(2013) Ying Wang et al.   CIRCULATION RESEARCH

Acyl-CoA Synthetase 1 Is Induced by Gram-negative Bacteria and Lipopolysaccharide and Is Required for Phospholipid Turnover in Stimulated Macrophages

(2013) Katya B. Rubinow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor Agonists Promote Prolonged Triglyceride Storage in Macrophages

(2013) Ying-ling Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Histo-Cytometry: A Method for Highly Multiplex Quantitative Tissue Imaging Analysis Applied to Dendritic Cell Subset Microanatomy in Lymph Nodes

(2012) Michael Y. Gerner et al.   IMMUNITY

Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1

(2012) J. E. Kanter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Insulin Resistance, Hyperglycemia, and Atherosclerosis

(2011) Karin E. Bornfeldt et al.   Cell Metabolism

LXRα Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8

(2011) Benoit Pourcet et al.   CIRCULATION RESEARCH

Cooperation of Adenosine with Macrophage Toll-4 Receptor Agonists Leads to Increased Glycolytic Flux through the Enhanced Expression ofPFKFB3Gene

(2011) Almudena Ruiz-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells

(2011) J. E. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage Fatty-acid Synthase Deficiency Decreases Diet-induced Atherosclerosis

(2010) Jochen G. Schneider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Oxidative Stress and Compartment of Gene Expression Determine Proatherosclerotic Effects of Inducible Nitric Oxide Synthase

(2009) Padmapriya Ponnuswamy et al.   AMERICAN JOURNAL OF PATHOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

(2008) Aksam J. Merched et al.   FASEB JOURNAL

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

A pathway for phagosome maturation during engulfment of apoptotic cells

(2008) Jason M. Kinchen et al.   NATURE CELL BIOLOGY

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY