Pharmacokinetics‐On‐a‐Chip: In Vitro Microphysiological Models for Emulating of Drugs ADME

In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment

(2021) Samantha V. Llewellyn et al.   Small

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development

(2020) Paul A. Walker et al.   ARCHIVES OF TOXICOLOGY

Miniaturization of liquid chromatography coupled to mass spectrometry. 2. Achievements on modern instrumentation for miniaturized liquid chromatography coupled to mass spectrometry

(2020) Deyber Arley Vargas Medina et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

h-FIBER: Microfluidic Topographical Hollow Fiber for Studies of Glomerular Filtration Barrier

(2020) Ruoxiao Xie et al.   ACS Central Science

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening

(2020) Kristina V. Kitaeva et al.   Frontiers in Bioengineering and Biotechnology

Current status and future directions of high-throughput ADME screening in drug discovery

(2020) Wilson Z. Shou   Journal of Pharmaceutical Analysis

Organ-on-a-chip engineering: Toward bridging the gap between lab and industry

(2020) Qasem Ramadan et al.   Biomicrofluidics

Microfluidic Skin‐on‐a‐Chip Models: Toward Biomimetic Artificial Skin

(2020) Emily Sutterby et al.   Small

Three-Dimensional Regeneration of Patient-Derived Intestinal Organoid Epithelium in a Physiodynamic Mucosal Interface-on-a-Chip

(2020) Yong Cheol Shin et al.   Micromachines

Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

(2020) Junyoung Kim et al.   ACS Nano

The liver, a functionalized vascular structure

(2020) Sylvie Lorente et al.   Scientific Reports

Computational Approaches in Preclinical Studies on Drug Discovery and Development

(2020) Fengxu Wu et al.   Frontiers in Chemistry

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

(2019) Leah M. Norona et al.   PLoS One

Microfluidic reactors for advancing the MS analysis of fast biological responses

(2019) Iulia M. Lazar et al.   Microsystems & Nanoengineering

Renal reabsorption in 3D vascularized proximal tubule models

(2019) Neil Y. C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubuloids derived from human adult kidney and urine for personalized disease modeling

(2019) Frans Schutgens et al.   NATURE BIOTECHNOLOGY

Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations

(2019) Yi Zhao et al.   MOLECULES

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications

(2019) Volker M. Lauschke et al.   Biotechnology Journal

Mechanisms of physiological tissue remodeling in animals: Manipulating tissue, organ, and organism morphology

(2019) Kaylinnette Pinet et al.   DEVELOPMENTAL BIOLOGY

Challenges and Opportunities in the Design of Liver-on-Chip Microdevices

(2019) Avner Ehrlich et al.   Annual Review of Biomedical Engineering

Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network

(2019) Jian Hui Low et al.   Cell Stem Cell

A standardised framework to identify optimal animal models for efficacy assessment in drug development

(2019) Guilherme S. Ferreira et al.   PLoS One

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

(2019) Christopher W. McAleer et al.   Scientific Reports

Electric and Electrochemical Microfluidic Devices for Cell Analysis

(2019) Kaoru Hiramoto et al.   Frontiers in Chemistry

Comparison of Bevacizumab Quantification Results in Plasma of Non-small Cell Lung Cancer Patients Using Bioanalytical Techniques Between LC-MS/MS, ELISA, and Microfluidic-based Immunoassay

(2019) Noriko Iwamoto et al.   AAPS Journal

A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies

(2019) Michelle Maurer et al.   BIOMATERIALS

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

(2019) Arbel Artzy-Schnirman et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier

(2019) Astgik Petrosyan et al.   Nature Communications

Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies

(2019) Hyun Mi Kang et al.   Scientific Reports

Miniaturized liquid chromatography focusing on analytical columns and mass spectrometry: A review

(2019) Edvaldo Vasconcelos Soares Maciel et al.   ANALYTICA CHIMICA ACTA

Technologies for Measuring Pharmacokinetic Profiles

(2018) A.A. Heller et al.   Annual Review of Analytical Chemistry

In Vivo Red Blood Cells/Plasma Partition Coefficient of Treosulfan and Its Active Monoepoxide in Rats

(2018) Michał Romański et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review

(2018) John G. Swales et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment

(2018) Karol Jaroch et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Design and fabrication of a liver-on-a-chip platform for convenient, highly efficient, and safe in situ perfusion culture of 3D hepatic spheroids

(2018) Li-Dong Ma et al.   LAB ON A CHIP

Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function

(2018) Gopu Sriram et al.   Materials Today

A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies

(2018) Ume-Kulsoom Shah et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

International regulatory requirements for skin sensitization testing

(2018) Amber B. Daniel et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

(2018) Catherine C Bell et al.   TOXICOLOGICAL SCIENCES

Towards fully integrated liquid chromatography on a chip: Evolution and evaluation

(2018) Farideh Haghighi et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies

(2018) Christian Maass et al.   Scientific Reports

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells

(2018) Aneta Przepiorski et al.   Stem Cell Reports

Engineered Kidney Tubules for Modeling Patient-Specific Diseases and Drug Discovery

(2018) Valentina Benedetti et al.   EBioMedicine

Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system

(2018) Carlota Oleaga et al.   BIOMATERIALS

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Recent Advances in Body-on-a-Chip Systems

(2018) Jong Hwan Sung et al.   ANALYTICAL CHEMISTRY

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

(2018) Haojia Wu et al.   Cell Stem Cell

Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip

(2018) Woojung Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gastrointestinal microphysiological systems

(2017) Sarah E Blutt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Development of capillary liquid chromatography: A personal perspective

(2017) Milos V. Novotny   JOURNAL OF CHROMATOGRAPHY A

A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control

(2017) J. R. Coppeta et al.   LAB ON A CHIP

Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening

(2017) Sreenivasa C. Ramaiahgari et al.   TOXICOLOGICAL SCIENCES

What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans?

(2017) Stephen C. Jameson et al.   Cold Spring Harbor Perspectives in Biology

Asymmetric BMP4 signalling improves the realism of kidney organoids

(2017) Christopher G. Mills et al.   Scientific Reports

Pharmacokinetics-on-a-Chip Using Label-Free SERS Technique for Programmable Dual-Drug Analysis

(2017) Jiayuan Fei et al.   ACS Sensors

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Physiology of Intestinal Absorption and Secretion

(2016) Pawel R. Kiela et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Characterization of tight junction disruption and immune response modulation in a miniaturized Caco-2/U937 coculture-based in vitro model of the human intestinal barrier

(2016) Qasem Ramadan et al.   BIOMEDICAL MICRODEVICES

Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature

(2016) Igho J. Onakpoya et al.   BMC Medicine

Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes

(2016) Yichiro Higuchi et al.   HEPATOLOGY RESEARCH

Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium

(2016) Fernando Garcia-Polite et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

A Continuously Infused Microfluidic Radioassay System for the Characterization of Cellular Pharmacokinetics

(2016) Z. Liu et al.   JOURNAL OF NUCLEAR MEDICINE

In vitro micro-physiological immune-competent model of the human skin

(2016) Qasem Ramadan et al.   LAB ON A CHIP

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

(2016) Danny Bavli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals

(2016) Shahab A Shaffiey et al.   Regenerative Medicine

Editor’s Highlight: Modeling Compound-Induced FibrogenesisIn VitroUsing Three-Dimensional Bioprinted Human Liver Tissues

(2016) Leah M. Norona et al.   TOXICOLOGICAL SCIENCES

Advances in and prospects of microchip liquid chromatography

(2016) James P. Grinias et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

(2016) Pranjul Shah et al.   Nature Communications

Simultaneous Real-Time Monitoring of Oxygen Consumption and Hydrogen Peroxide Production in Cells Using Our Newly Developed Chip-Type Biosensor Device

(2016) Ankush Prasad et al.   Frontiers in Physiology

The Tape-Stripping Technique as a Method for Drug Quantification in Skin

(2016) Jose Juan Escobar-Chavez et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro

(2016) Deborah G. Nguyen et al.   PLoS One

Skin-on-a-chip model simulating inflammation, edema and drug-based treatment

(2016) Maierdanjiang Wufuer et al.   Scientific Reports

Enzyme-Based Microfluidic Chip Coupled to Graphene Electrodes for the Detection of D-Amino Acid Enantiomer-Biomarkers

(2015) Pilar Batalla et al.   ANALYTICAL CHEMISTRY

A microfluidically perfused three dimensional human liver model

(2015) Knut Rennert et al.   BIOMATERIALS

In vitro skin models as a tool in optimization of drug formulation

(2015) Gøril Eide Flaten et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Transporter assays as usefulin vitrotools in drug discovery and development

(2015) Donna A. Volpe   Expert Opinion on Drug Discovery

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Evolution in miniaturized column liquid chromatography instrumentation and applications: An overview

(2015) Carlos E.D. Nazario et al.   JOURNAL OF CHROMATOGRAPHY A

Instrument platforms for nano liquid chromatography

(2015) Jozef Šesták et al.   JOURNAL OF CHROMATOGRAPHY A

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

Mass spectrometry in the pharmacokinetic studies of anticancer natural products

(2015) Sara Crotti et al.   MASS SPECTROMETRY REVIEWS

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Mitigating risk in academic preclinical drug discovery

(2015) Jayme L. Dahlin et al.   NATURE REVIEWS DRUG DISCOVERY

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In silico ADME/T modelling for rational drug design

(2015) Yulan Wang et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1

(2015) Lydia Aschauer et al.   TOXICOLOGY IN VITRO

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

(2015) Benjamin S. Freedman et al.   Nature Communications

Rapid, automated, parallel quantitative immunoassays using highly integrated microfluidics and AlphaLISA

(2015) Zeta Tak For Yu et al.   Scientific Reports

Engineering Cell-Compatible Paper Chips for Cell Culturing, Drug Screening, and Mass Spectrometric Sensing

(2015) Qiushui Chen et al.   Advanced Healthcare Materials

Transepithelial glucose transport and Na+/K+ homeostasis in enterocytes: an integrative model

(2014) Kristian Thorsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of pharmacokinetic studies in drug discovery: where are we now, how did we get here and where are we going?

(2014) Peter JH Webborn   Future Medicinal Chemistry

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Electrochemical detection techniques in micro- and nanofluidic devices

(2014) Aytug Gencoglu et al.   Microfluidics and Nanofluidics

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations

(2014) Xiannu Jin et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

A Perspective on Quantum Mechanics Calculations in ADMET Predictions

(2013) J. Bowen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A Sensitive Microchip-Based Immunosensor for Electrochemical Detection of Low-Level Biomarker S100B

(2013) Yun Liu et al.   ELECTROANALYSIS

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids

(2013) Rebecca L. DiMarco et al.   Integrative Biology

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

Chemical predictive modelling to improve compound quality

(2013) John G. Cumming et al.   NATURE REVIEWS DRUG DISCOVERY

The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

(2013) Andrés Olivares-Morales et al.   PHARMACEUTICAL RESEARCH

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs

(2012) Laetitia Shintu et al.   ANALYTICAL CHEMISTRY

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip

(2012) Leila Choucha-Snouber et al.   BIOTECHNOLOGY AND BIOENGINEERING

Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells

(2012) Henner F. Farin et al.   GASTROENTEROLOGY

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device

(2012) Dan Gao et al.   LAB ON A CHIP

NutriChip: nutrition analysis meets microfluidics

(2012) Qasem Ramadan et al.   LAB ON A CHIP

The Fraction Dose Absorbed, in Humans, and High Jejunal Human Permeability Relationship

(2012) Arik Dahan et al.   MOLECULAR PHARMACEUTICS

The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule

(2012) Sarah E. Jenkinson et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Use of Animal Models of Human Disease for Nonclinical Safety Assessment of Novel Pharmaceuticals

(2012) Sherry J. Morgan et al.   TOXICOLOGIC PATHOLOGY

In Vivo-In Vitro-In Silico Pharmacokinetic Modelling in Drug Development

(2011) Olavi Pelkonen et al.   CLINICAL PHARMACOKINETICS

A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells

(2010) Nicholas Ferrell et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integration ofin silicoandin vitroplatforms for pharmacokinetic–pharmacodynamic modeling

(2010) Jong Hwan Sung et al.   Expert Opinion on Drug Metabolism & Toxicology

HK-2 Human Renal Proximal Tubule Cells as a Model for G Protein–Coupled Receptor Kinase Type 4–Mediated Dopamine 1 Receptor Uncoupling

(2010) John J. Gildea et al.   HYPERTENSION

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

(2010) Manthena V. S. Varma et al.   JOURNAL OF MEDICINAL CHEMISTRY

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Microfluidic Immunoassays

(2010) Chun-Che Lin et al.   Journal of the Association for Laboratory Automation.

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

A Microfluidic System to Evaluate Intestinal Absorption

(2009) Yuki IMURA et al.   ANALYTICAL SCIENCES

Are animal models predictive for humans?

(2009) Niall Shanks et al.   Philosophy Ethics and Humanities in Medicine

Liquid chromatography–mass spectrometry in in vitro drug metabolite screening

(2008) Ari Tolonen et al.   DRUG DISCOVERY TODAY

Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid

(2008) X. Liu et al.   DRUG METABOLISM AND DISPOSITION

Biotransformation of Drugs in Human Skin

(2008) C. K. Svensson   DRUG METABOLISM AND DISPOSITION

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS