Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment

Title
Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment
Authors
Keywords
IVIVE, 3R, Physiologically based pharmacokinetic, ADME (Absorption, distribution, metabolism and excretion), 3D cell cultures, DDI (Drug-drug interaction)
Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 147, Issue -, Pages 297-312
Publisher
Elsevier BV
Online
2017-07-27
DOI
10.1016/j.jpba.2017.07.023

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