Review
Veterinary Sciences
Longfei Zhang, Hongbing Xie, Yongqiang Wang, Hongjuan Wang, Jianhe Hu, Gaiping Zhang
Summary: Pharmacokinetic/pharmacodynamic (PK/PD) integration models are used to investigate the antimicrobial activity characteristics of drugs targeting pathogenic bacteria through comprehensive analysis of the interactions between PK and PD parameters. PK/PD models have been widely applied in the development of new drugs, optimization of the dosage regimen, and prevention and treatment of drug-resistant bacteria.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Marit Keuper-Navis, Markus Walles, Birk Poller, Adam Myszczyszyn, Thomas K. van der Made, Joanne Donkers, Hossein Eslami Amirabadi, Martijn J. Wilmer, Saskia Aan, Bart Spee, Rosalinde Masereeuw, Evita van de Steeg
Summary: Organ-on-chip (OoC) technology has the potential to improve the prediction of human oral bioavailability and intrinsic clearance. This review discusses the functionality and application of OoC models in current drug development practice, and summarizes the use of multi-OoC models for pharmacokinetic (PK) studies. Challenges and recommended parameters for a minimal viable platform of a multi-OoC model are provided. The translation to in vivo PK profiles is also discussed, which is essential for routine application of OoC models in drug development.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Engineering, Biomedical
Yogendra Pratap Singh, Joseph Christakiran Moses, Nandana Bhardwaj, Biman B. Mandal
Summary: This article provides an overview of different types of in vitro osteoarthritis models, including their advantages and disadvantages, as well as various growth factors, cytokines, and chemicals used for inducing OA-like conditions. It also focuses on potential therapeutic targets to enhance the understanding of OA mechanisms and treatment.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Infectious Diseases
Anouk E. Muller, Marie Attwood, Sanne Van den Berg, Rajesh Chavan, Hariharan Periasamy, Alan Noel, Alasdair MacGowan
Summary: This study identified the pharmacodynamic targets of cefepime using both in vivo and in vitro models, and found that cefepime has lower requirements compared to other cephalosporins, possibly due to its better permeation properties and enhanced bactericidal action driven by multiple PBP affinities.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Iris K. Minichmayr, Vincent Aranzana-Climent, Lena E. Friberg
Summary: Pharmacokinetic/pharmacodynamic (PKPD) models are valuable tools for characterizing and translating antibiotic effects. These models provide a more accurate description of the time course of antibiotic effects, considering mechanistic knowledge of pathogens and drugs. This review provides a comprehensive overview of previously published PKPD models, highlighting their details and main development purposes.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Pharmacology & Pharmacy
Thomas J. DePalma, Hemamylammal Sivakumar, Aleksander Skardal
Summary: In recent years, bioengineered in vitro models of cancer have been widely used for studying disease mechanisms, testing drugs, and developing personalized treatment options. This review discusses the considerations in developing accurate model systems that mimic the tumor microenvironment and can answer specific scientific questions. The importance of cell sourcing and biomaterial selection is emphasized, and examples of model form factors and biofabrication techniques are provided. The review also explores the application of these models in the context of glioblastoma, illustrating how they contribute to cancer biology research and drug development.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Jong Hwan Sung, Jae Jung Kim
Summary: The skin is the largest organ that provides protection and interacts with other organs in the body, making it important for studying various diseases. In vitro skin models, including organ-on-a-chip technology, offer valuable tools for pharmaceutical, cosmetics, and food industries to understand drug metabolism, dermatological diseases, and the interaction of the skin with other organs.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Review
Immunology
Daphne M. Peelen, Martin J. Hoogduijn, Dennis A. Hesselink, Carla C. Baan
Summary: Endothelial cells play a key role in acute and chronic rejection of solid organ transplants, with significant impact on organ function. Innovative 3D in vitro models have been developed to expand understanding of endothelial cell roles and potentially discover new therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Neurosciences
Jing Gong, Tianyue Meng, Jun Yang, Ning Hu, Hezhao Zhao, Tian Tian
Summary: Brain organoids are three-dimensional structures derived from human induced pluripotent stem cells, capable of modeling brain development, evolution, and diseases in vitro. Advances in biomaterials, technologies, and cell biology have enabled the construction of human-specific brain structures, although challenges like long-term culture, necrosis, and hypoxic cores still hinder organoid growth.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Immunology
Nicoletta Manduca, Ester Maccafeo, Ruggero De Maria, Antonella Sistigu, Martina Musella
Summary: Cancer immunotherapy, despite showing extended progression-free survival in cancer treatment compared to conventional therapies, is effective in only a minority of patients. To improve its applicability, it is crucial to overcome obstacles such as the lack of preclinical models that accurately depict the local tumor microenvironment (TME), which significantly influences disease onset, progression, and response to therapy. This review provides a comprehensive overview of current 3D models, including tumor spheroids, organoids, and immune Tumor-on-a-Chip models, that mimic the complexity and dynamics of the TME. It emphasizes the importance of understanding the TME as a major target in anticancer therapy and highlights the advantages, translational potentials, challenges, and limitations of these models.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Yubing Leng, Xiaorui Li, Fuyin Zheng, Hui Liu, Chunyan Wang, Xudong Wang, Yulong Liao, Jiangyue Liu, Kaiqi Meng, Jiaheng Yu, Jingyi Zhang, Binyu Wang, Yingjun Tan, Meili Liu, Xiaoling Jia, Deyu Li, Yinghui Li, Zhongze Gu, Yubo Fan
Summary: The neuromuscular junction (NMJ) is a peripheral synaptic connection that enables muscle contraction and voluntary motor movement. Recent advances in in vitro NMJ models have allowed for better understanding, control, and evaluation of its functions, using techniques such as organ-on-a-chip and biohybrid robotics. Functional analysis methods including the patch-clamp technique, microelectrode arrays, calcium imaging, and various stimulus methods have also been developed. These models have potential applications in disease modeling and drug screening for neuromuscular diseases.
ADVANCED MATERIALS
(2023)
Article
Cell & Tissue Engineering
Joris Van Meenen, Sorcha Ni Dhubhghaill, Bert Van den Bogerd, Carina Koppen
Summary: The cornea is a crucial barrier in the development of ophthalmic formulations, with animal models currently being the most representative but having differences from human corneas and ethical limitations. In vitro approaches are being developed to address these issues. The emerging generation of three-dimensional in vitro models, such as spheroids, organoids, and organs-on-chips, shows promise in advancing the field of corneal equivalents.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Connor O'Farrell, Konstantinos Stamatopoulos, Mark Simmons, Hannah Batchelor
Summary: The development of orally ingestible medical devices requires the use of models that simulate the gastrointestinal environment on both a macro and micro scale. Various in vitro tools are available for characterizing these devices, each with its own benefits and limitations. The selection of models for evaluation should be based on the functionality and mechanism of the device.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Engineering, Biomedical
Ian T. Whelan, E. Moeendarbary, David A. Hoey, Daniel J. Kelly
Summary: The emerging microphysiological systems (MPS) technology allows for the engineering of more physiologically relevant vasculature in vitro, potentially impacting the development of bone research. Engineering vasculature within the specific design constraints of the bone niche is challenging. Researchers are working towards providing technical guidance for the biofabrication of vascularised bone tissue within MPS devices.
Review
Pharmacology & Pharmacy
Jennifer H. Hammel, Jonathan M. Zatorski, Sophie R. Cook, Rebecca R. Pompano, Jennifer M. Munson
Summary: Advancements in 3D cell culture, microscale fluidic control, and cellular analysis have allowed for the development of more physiologically-relevant engineered models of human organs. However, these models often overlook the important role of the immune system. This review discusses key components to consider in designing immune-competent models and reviews recent applications of immune models for cancer therapeutics screening, engineered T cell evaluation, autoimmune disease modeling, and vaccine efficacy screening.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Environmental Sciences
Marc-Andre Verner, Anne E. Loccisano, Nils-Halvdan Morken, Miyoung Yoon, Huali Wu, Robin McDougall, Mildred Maisonet, Michele Marcus, Reiko Kishi, Chihiro Miyashita, Mei-Huei Chen, Wu-Shiun Hsieh, Melvin E. Andersen, Harvey J. Clewell, Matthew P. Longnecker
ENVIRONMENTAL HEALTH PERSPECTIVES
(2015)
Article
Medicine, Legal
Kathleen Brown, Martin Phillips, Christopher Grulke, Miyoung Yoon, Bruce Young, Robin McDougall, Jeremy Leonard, Jingtao Lu, William Lefew, Yu-Mei Tan
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2015)
Article
Oncology
Marc-Andre Verner, Delphine Bachelet, Robin McDougall, Michel Charbonneau, Pascal Guenel, Sami Haddad
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2011)
Article
Environmental Sciences
Liesbeth Weijs, Anthony C. Roach, Raymond S. H. Yang, Robin McDougall, Michael Lyons, Conrad Housand, Detlef Tibax, Therese Manning, John Chapman, Katelyn Edge, Adrian Covaci, Ronny Blust
Article
Environmental Sciences
Marc-Andre Verner, Robin McDougall, Anders Glynn, Melvin E. Andersen, Harvey J. Clewell, Matthew P. Longnecker
ENVIRONMENTAL HEALTH PERSPECTIVES
(2013)
Article
Toxicology
Marc-Andre Verner, Robin McDougall, Gunnar Johanson
TOXICOLOGY LETTERS
(2012)
Article
Neurosciences
Jean C. Cruz Hernandez, Oliver Bracko, Calvin J. Kersbergen, Victorine Muse, Mohammad Haft-Javaherian, Maxime Berg, Laibaik Park, Lindsay K. Vinarcsik, Iryna Ivasyk, Daniel A. Rivera, Yiming Kang, Marta Cortes-Canteli, Myriam Peyrounette, Vincent Doyeux, Amy Smith, Joan Zhou, Gabriel Otte, Jeffrey D. Beverly, Elizabeth Davenport, Yohan Davit, Charles P. Lin, Sidney Strickland, Costantino Iadecola, Sylvie Lorthois, Nozomi Nishimura, Chris B. Schaffer
NATURE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Mohammad Haft-Javaherian, Linjing Fang, Victorine Muse, Chris B. Schaffer, Nozomi Nishimura, Mert R. Sabuncu
Article
Multidisciplinary Sciences
Oliver Bracko, Lindsay K. Vinarcsik, Jean C. Cruz Hernandez, Nancy E. Ruiz-Uribe, Mohammad Haft-Javaherian, Kaja Falkenhain, Egle M. Ramanauskaite, Muhammad Ali, Aditi Mohapatra, Madisen A. Swallow, Brendah N. Njiru, Victorine Muse, Pietro E. Michelucci, Nozomi Nishimura, Chris B. Schaffer
SCIENTIFIC REPORTS
(2020)
Article
Computer Science, Artificial Intelligence
Victorine P. Muse, Alejandro Aguayo-Orozco, Sedrah B. Balaganeshan, Soren Brunak
Summary: We found differences in mortality, age, and sex in relation to reference intervals (RIs) for laboratory tests in a population-wide data of nearly 2 million hospital patients in Denmark, which included over 300 million measurements. A low-parameter mathematical wave-based modification method was developed to adjust for dietary and environment influences throughout the year. The resulting mathematical fit improved the association rates between re-classified abnormal laboratory tests, patient diagnoses, and mortality. This study highlights the need for seasonally modified RIs and presents an approach that could reduce over- and underdiagnosis, impacting physician-patient interactions and electronic health record research as a whole.
Article
Nuclear Science & Technology
Robin McDougall, Scott B. Nokleby, Ed Waller
JOURNAL OF NUCLEAR ENGINEERING AND RADIATION SCIENCE
(2018)