Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

(2020) David B. Chou et al.   Nature Biomedical Engineering

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

(2020) Richard Novak et al.   Nature Biomedical Engineering

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

(2018) Rachelle Prantil-Baun et al.   Annual Review of Pharmacology and Toxicology

A compartment-quasi-3D multiscale approach for drug absorption, transport, and retention in the human lungs

(2018) Ravishekar Ravi Kannan et al.   International Journal for Numerical Methods in Biomedical Engineering

Maximizing the impact of microphysiological systems with in vitro–in vivo translation

(2018) Murat Cirit et al.   LAB ON A CHIP

Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies

(2018) Christian Maass et al.   Scientific Reports

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

(2017) Christian Maass et al.   Integrative Biology

A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control

(2017) J. R. Coppeta et al.   LAB ON A CHIP

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

(2017) Ben M. Maoz et al.   LAB ON A CHIP

Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function

(2017) Olivier Y. F. Henry et al.   LAB ON A CHIP

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Multiscale Modeling in the Clinic: Drug Design and Development

(2016) Colleen E. Clancy et al.   ANNALS OF BIOMEDICAL ENGINEERING

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

A Liver-Centric Multiscale Modeling Framework for Xenobiotics

(2016) James P. Sluka et al.   PLoS One

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

Hepatotoxicity and pharmacokinetics of cisplatin in combination therapy with a traditional Chinese medicine compound of Zengmian Yiliu granules in ICR mice and SKOV-3-bearing nude mice

(2015) Can Gong et al.   BMC Complementary and Alternative Medicine

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine

(2013) M. Jamei et al.   CLINICAL PHARMACOKINETICS

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data

(2013) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies

(2012) Yuan Chen et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

(2012) A Rostami-Hodjegan   CLINICAL PHARMACOLOGY & THERAPEUTICS

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

(2012) Brett A. Howell et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Determination of Nicotine Absorption from Multiple Tobacco Products and Nicotine Gum

(2012) H. Digard et al.   NICOTINE & TOBACCO RESEARCH

Convective transport of highly plasma protein bound drugs facilitates direct penetration into deep tissues after topical application

(2011) Yuri Dancik et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Comparison of the effects of nicotine upon the transcellular electrical resistance and sucrose permeability of human ECV304/rat C6 co-cultures and human CaCo2 cells

(2011) Antonio Rodriguez-Gaztelumendi et al.   TOXICOLOGY LETTERS

Human Blood Concentrations of Cotinine, a Biomonitoring Marker for Tobacco Smoke, Extrapolated from Nicotine Metabolism in Rats and Humans and Physiologically Based Pharmacokinetic Modeling

(2010) Hiroshi Yamazaki et al.   International Journal of Environmental Research and Public Health

Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development

(2009) Masato Chiba et al.   AAPS Journal

Physicochemical Determinants of Human Renal Clearance

(2009) Manthena V. S. Varma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Are animal models predictive for humans?

(2009) Niall Shanks et al.   Philosophy Ethics and Humanities in Medicine

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

(2008) M DANHOF et al.   TRENDS IN PHARMACOLOGICAL SCIENCES