Microfluidic Skin‐on‐a‐Chip Models: Toward Biomimetic Artificial Skin

Polylactic is a Sustainable, Low Absorption, Low Autofluorescence Alternative to Other Plastics for Microfluidic and Organ-on-Chip Applications

(2020) Alfredo E. Ongaro et al.   ANALYTICAL CHEMISTRY

Real-time sensors for live monitoring of disease and drug analysis in microfluidic model of proximal tubule

(2020) Arun Asif et al.   Microfluidics and Nanofluidics

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

(2020) Eun Kim et al.   EBioMedicine

Testing the Effectiveness of Curcuma longa Leaf Extract on a Skin Equivalent Using a Pumpless Skin-on-a-Chip Model

(2020) Kyunghee Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Photolithography-Free Skin-on-a-Chip for Parallel Permeation Assays

(2019) Naoki Sasaki et al.   SENSORS AND MATERIALS

Topical and transdermal drug delivery: from simple potions to smart technologies

(2019) Heather A.E. Benson et al.   Current Drug Delivery

Current Strategies and Future Perspectives of Skin-on-a-Chip Platforms: Innovations, Technical Challenges and Commercial Outlook

(2019) Ayça Bal-Öztürk et al.   CURRENT PHARMACEUTICAL DESIGN

Keratinocytes are mechanoresponsive to the microflow‐induced shear stress

(2019) Tarun Agarwal et al.   Cytoskeleton

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

A MEMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro

(2019) Jungpyo Lee et al.   Microsystems & Nanoengineering

Studying the Response of Aortic Endothelial Cells under Pulsatile Flow Using a Compact Microfluidic System

(2019) Mokhaled Mohammed et al.   ANALYTICAL CHEMISTRY

Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs

(2019) Alexandru-Emil Matei et al.   ANNALS OF THE RHEUMATIC DISEASES

Chip modularity enables molecular information access from organ-on-chip devices with quality control

(2019) Wu Shang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Integrating Flexible Electrochemical Sensor into Microfluidic Chip for Simulating and Monitoring Vascular Mechanotransduction

(2019) Zi‐He Jin et al.   Small

Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues

(2019) Ruoxiao Xie et al.   Small

Skin-on-a-Chip Device for Ex Vivo Monitoring of Transdermal Delivery of Drugs—Design, Fabrication, and Testing

(2019) Bence Lukács et al.   Pharmaceutics

Reconfigurable, Self-Sufficient Convective Heat Exchanger for Temperature Control of Microfluidic Systems

(2019) Jiu Yang Zhu et al.   ANALYTICAL CHEMISTRY

Shared and distinct mechanisms of fibrosis

(2019) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

Cancer Modeling‐on‐a‐Chip with Future Artificial Intelligence Integration

(2019) Kirsten Lee Fetah et al.   Small

Tetrafluoroethylene-Propylene Elastomer for Fabrication of Microfluidic Organs-on-Chips Resistant to Drug Absorption

(2019) Emi Sano et al.   Micromachines

Side-effect test of sorafenib using 3-D skin equivalent based on microfluidic skin-on-a-chip

(2019) Hye Mi Jeon et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Lipid nanocarriers as skin drug delivery systems: Properties, mechanisms of skin interactions and medical applications

(2018) M. Sala et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fibroblasts change spreading capability and mechanical properties in a direct interaction with keratinocytes in conditions mimicking wound healing

(2018) Barbara Orzechowska et al.   JOURNAL OF BIOMECHANICS

Development of 3D skin-equivalent in a pump-less microfluidic chip

(2018) Hyun Jeong Song et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Microsensor systems for cell metabolism – from 2D culture to organ-on-chip

(2018) Jochen Kieninger et al.   LAB ON A CHIP

Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function

(2018) Gopu Sriram et al.   Materials Today

Inflammation-on-a-Chip: Probing the Immune System Ex Vivo

(2018) Daniel Irimia et al.   TRENDS IN BIOTECHNOLOGY

Skin-on-a-Chip: Transepithelial Electrical Resistance and Extracellular Acidification Measurements through an Automated Air-Liquid Interface

(2018) Frank Alexander et al.   Genes

Development of wrinkled skin-on-a-chip (WSOC) by cyclic uniaxial stretching

(2018) Ho Yeong Lim et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Vessel-on-a-chip with Hydrogel-based Microfluidics

(2018) Jing Nie et al.   Small

3D Cell Printing of Perfusable Vascularized Human Skin Equivalent Composed of Epidermis, Dermis, and Hypodermis for Better Structural Recapitulation of Native Skin

(2018) Byoung Soo Kim et al.   Advanced Healthcare Materials

Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model

(2018) Sahar Biglari et al.   Advanced Healthcare Materials

In vitro psoriasis models with focus on reconstructed skin models as promising tools in psoriasis research

(2017) Eline Desmet et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Next generation human skin constructs as advanced tools for drug development

(2017) HE Abaci et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Fabrication of a pumpless, microfluidic skin chip from different collagen sources

(2017) Hyun Jeong Song et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms

(2017) V. S. Shirure et al.   LAB ON A CHIP

Modeling Physiological Events in 2D vs. 3D Cell Culture

(2017) Kayla Duval et al.   PHYSIOLOGY

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress and Future Prospectives in Skin-on-Chip Development with Emphasis on the use of Different Cell Types and Technical Challenges

(2017) Lenie J. van den Broek et al.   Stem Cell Reviews and Reports

Controlling Differentiation of Stem Cells for Developing Personalized Organ-on-Chip Platforms

(2017) Armin Geraili et al.   Advanced Healthcare Materials

Global Skin Disease Morbidity and Mortality

(2017) Chante Karimkhani et al.   JAMA Dermatology

Progress and Future Prospectives in Skin-on-Chip Development with Emphasis on the use of Different Cell Types and Technical Challenges

(2017) Lenie J. van den Broek et al.   Stem Cell Reviews and Reports

Medical devices on chips

(2017) Allan Guan et al.   Nature Biomedical Engineering

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Current and emerging vascularization strategies in skin tissue engineering

(2016) Florian S. Frueh et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

The role of tight junctions in skin barrier function and dermal absorption

(2016) Katja Bäsler et al.   JOURNAL OF CONTROLLED RELEASE

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Self-contained microfluidic systems: a review

(2016) Mitchell Boyd-Moss et al.   LAB ON A CHIP

In vitro micro-physiological immune-competent model of the human skin

(2016) Qasem Ramadan et al.   LAB ON A CHIP

Cell stretching devices as research tools: engineering and biological considerations

(2016) Harshad Kamble et al.   LAB ON A CHIP

Role of biomechanical forces in the natural history of coronary atherosclerosis

(2016) Adam J. Brown et al.   Nature Reviews Cardiology

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

(2016) Fuyin Zheng et al.   Small

Substrate stiffness does affect the fate of human keratinocytes

(2016) Prerak Gupta et al.   RSC Advances

Skin Diseases Modeling using Combined Tissue Engineering and Microfluidic Technologies

(2016) Mohammad Hossein Mohammadi et al.   Advanced Healthcare Materials

Skin-on-a-chip model simulating inflammation, edema and drug-based treatment

(2016) Maierdanjiang Wufuer et al.   Scientific Reports

Transdermal patches: history, development and pharmacology

(2015) Michael N Pastore et al.   BRITISH JOURNAL OF PHARMACOLOGY

Development of full-thickness human skin equivalents with blood and lymph-like capillary networks by cell coating technology

(2015) Michiya Matsusaki et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Pumpless microfluidic platform for drug testing on human skin equivalents

(2015) Hasan Erbil Abaci et al.   LAB ON A CHIP

Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis

(2015) Z. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

Understanding fibroblast heterogeneity in the skin

(2015) Ryan R. Driskell et al.   TRENDS IN CELL BIOLOGY

Mechanical Stretch on Human Skin Equivalents Increases the Epidermal Thickness and Develops the Basement Membrane

(2015) Eijiro Tokuyama et al.   PLoS One

Decellularized Allogeneic and Xenogeneic Tissue as a Bioscaffold for Regenerative Medicine: Factors that Influence the Host Response

(2014) Stephen F. Badylak   ANNALS OF BIOMEDICAL ENGINEERING

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Low-Intensity Pulsed Ultrasound Stimulation Facilitates Osteogenic Differentiation of Human Periodontal Ligament Cells

(2014) Bo Hu et al.   PLoS One

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

(2014) B. A. Morgan   Cold Spring Harbor Perspectives in Medicine

A microscale anisotropic biaxial cell stretching device for applications in mechanobiology

(2013) Dominique Tremblay et al.   BIOTECHNOLOGY LETTERS

Intradermal adipocytes mediate fibroblast recruitment during skin wound healing

(2013) B. A. Schmidt et al.   DEVELOPMENT

Skin penetration enhancers

(2013) Majella E. Lane   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Safety Assessment of Trimoniums as Used in Cosmetics

(2013) Lillian C. Becker et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Contribution of Tight Junction Proteins to Ion, Macromolecule, and Water Barrier in Keratinocytes

(2013) Nina Kirschner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Pneumatic cell stretching system for cardiac differentiation and culture

(2013) Joose Kreutzer et al.   MEDICAL ENGINEERING & PHYSICS

Asymmetric Migration of Human Keratinocytes under Mechanical Stretch and Cocultured Fibroblasts in a Wound Repair Model

(2013) Dongyuan Lü et al.   PLoS One

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Upcyte® Microvascular Endothelial Cells Repopulate Decellularized Scaffold

(2012) Katharina Scheller et al.   TISSUE ENGINEERING PART C-METHODS

Cyclic stretch induces upregulation of endothelin-1 with keratinocytes in vitro: Possible role in mechanical stress-induced hyperpigmentation

(2011) Masakazu Kurita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Validation of a Static Franz Diffusion Cell System for In Vitro Permeation Studies

(2010) Shiow-Fern Ng et al.   AAPS PHARMSCITECH

In vitro models for human skin disease

(2010) Lydia Semlin et al.   DRUG DISCOVERY TODAY

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Targeting to the hair follicles: Current status and potential

(2010) Hanna Wosicka et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Mechanical stretching modulates growth direction and MMP-9 release in human keratinocyte monolayer

(2010) Filippo Renò et al.   Cell Adhesion & Migration

Assessment of fibroblast cells submitted to ultrasonic irradiation

(2008) R DEOLIVEIRA et al.   CELL BIOLOGY INTERNATIONAL

Characterization of microfluidic human epidermal keratinocyte culture

(2008) Adrian T. O’Neill et al.   CYTOTECHNOLOGY

The Effect of Different Frequencies of Stretch on Human Dermal Keratinocyte Proliferation and Survival

(2008) Kengo Nishimura et al.   JOURNAL OF SURGICAL RESEARCH

Transdermal drug delivery

(2008) Mark R Prausnitz et al.   NATURE BIOTECHNOLOGY