Reactive Oxygen Species: Not Omnipresent but Important in Many Locations

Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin

(2021) Lorna S. Thorne et al.   Scientific Reports

NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments

(2021) Simona Damiano et al.   Frontiers in Cellular and Infection Microbiology

Oxidative Eustress: On Constant Alert for Redox Homeostasis

(2021) Helmut Sies   Redox Biology

Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice

(2021) Hoi-Shan Wong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apocynin ameliorates NADPH oxidase 4 (NOX4) induced oxidative damage in the hypoxic human retinal Müller cells and diabetic rat retina

(2021) Ajmal Ahmad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A multiplier peroxiporin signal transduction pathway powers piscine spermatozoa

(2021) François Chauvigné et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of ROS in Macrophages and Antimicrobial Immunity

(2021) Marc Herb et al.   Antioxidants

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

(2021) Celia Andrés Juan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity

(2021) Hao-Yun Peng et al.   Frontiers in Immunology

Chalcone suppresses tumor growth through NOX4-IRE1α sulfonation-RIDD-miR-23b axis

(2021) Hyun-Kyoung Kim et al.   Redox Biology

Calotropis gigantea stem bark extract induced apoptosis related to ROS and ATP production in colon cancer cells

(2021) Thanwarat Winitchaikul et al.   PLoS One

A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation

(2021) Orna Ernst et al.   Science Signaling

Roles of Phase Separation for Cellular Redox Maintenance

(2021) Yuichi Saito et al.   Frontiers in Genetics

Neutrophil-derived reactive oxygen species promote tumor colonization

(2021) Jianghong Zhong et al.   Communications Biology

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging

(2020) Li Geng et al.   Scientific Reports

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

(2020) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

(2020) Andrew S. Mendiola et al.   NATURE IMMUNOLOGY

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye

(2020) Anne Wolf et al.   Nature Communications

A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action

(2020) Joana Reis et al.   Redox Biology

Nox4 regulates InsP 3 receptor‐dependent Ca 2+ release into mitochondria to promote cell survival

(2020) Matteo Beretta et al.   EMBO JOURNAL

A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia

(2020) Meredith K. Loth et al.   MOLECULAR NEUROBIOLOGY

Na+ controls hypoxic signalling by the mitochondrial respiratory chain

(2020) Pablo Hernansanz-Agustín et al.   NATURE

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

(2020) Andrew V. Anzalone et al.   NATURE BIOTECHNOLOGY

Detection of Total Reactive Oxygen Species in Adherent Cells by 2',7'-Dichlorodihydrofluorescein Diacetate Staining

(2020) Hyeoncheol Kim et al.   Jove-Journal of Visualized Experiments

Xanthine oxidase-lactoperoxidase system and innate immunity: Biochemical actions and physiological roles

(2020) Saad S. Al-Shehri et al.   Redox Biology

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

(2020) Qiyi Zhao et al.   CELL

Epithelial-Derived Reactive Oxygen Species Enable AppBCX-Mediated Aerobic Respiration of Escherichia coli during Intestinal Inflammation

(2020) Rachael B. Chanin et al.   Cell Host & Microbe

Mitochondrial Reactive Oxygen Species Participate in Signaling Triggered by Heme in Macrophages and upon Hemolysis

(2020) Elisa B. Prestes et al.   JOURNAL OF IMMUNOLOGY

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

(2020) Hongzhang Deng et al.   Nature Communications

CRISPRoff enables spatio-temporal control of CRISPR editing

(2020) Jared Carlson-Stevermer et al.   Nature Communications

Anaerobic Respiration of NOX1-Derived Hydrogen Peroxide Licenses Bacterial Growth at the Colonic Surface

(2020) Brittany M. Miller et al.   Cell Host & Microbe

Role of NADPH oxidase in MAPK signaling activation by a 50 Hz magnetic field in human neuroblastoma cells

(2020) María Antonia Martínez et al.   ELECTROMAGNETIC BIOLOGY AND MEDICINE

Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging

(2020) Megumi Inomata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS and hypoxia signaling regulate periodic metabolic arousal during insect dormancy to coordinate glucose, amino acid, and lipid metabolism

(2020) Chao Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When Friendship Turns Sour: Effective Communication Between Mitochondria and Intracellular Organelles in Parkinson's Disease

(2020) Tsu-Kung Lin et al.   Frontiers in Cell and Developmental Biology

Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO

(2019) Marc Herb et al.   Science Signaling

Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

(2019) Yifan Zhang et al.   NATURE IMMUNOLOGY

Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature

(2019) Lampson M. Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production

(2019) Ran Wei et al.   Scientific Reports

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

(2019) Takafumi Suzuki et al.   Cell Reports

Characterization of aquaporin-driven hydrogen peroxide transport

(2019) Hao Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit

(2019) Francisco J. Roca et al.   CELL

Mechanisms of ROS Regulation of Plant Development and Stress Responses

(2019) Honglin Huang et al.   Frontiers in Plant Science

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

(2019) Lian-Jiu Su et al.   Oxidative Medicine and Cellular Longevity

ROS as a novel indicator to predict anticancer drug efficacy

(2019) Tarek Zaidieh et al.   BMC CANCER

Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function

(2018) Yasuaki Aratani   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mini-Review: Oxidative stress, redox stress or redox success ?

(2018) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The β 2 Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes

(2018) Alexander Gluschko et al.   Cell Host & Microbe

N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why

(2018) Giancarlo Aldini et al.   FREE RADICAL RESEARCH

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

(2018) Arnau Hervera et al.   NATURE CELL BIOLOGY

Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact

(2018) Nadav Shai et al.   Nature Communications

Role of C-Reactive Protein at Sites of Inflammation and Infection

(2018) Nicola R. Sproston et al.   Frontiers in Immunology

Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus

(2018) Basel H. Abuaita et al.   Cell Host & Microbe

HIF-1α-regulated MIF activation and Nox2-dependent ROS generation promote Leishmania amazonensis killing by macrophages under hypoxia

(2018) Diego Alonso et al.   CELLULAR IMMUNOLOGY

Intracellular ROS levels determine the apoptotic potential of keratinocyte by Quantum Dot via blockade of AKT Phosphorylation

(2017) Eun Young Lee et al.   EXPERIMENTAL DERMATOLOGY

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

The Peroxisome-Mitochondria Connection: How and Why?

(2017) Marc Fransen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Type I interferon enhances necroptosis ofSalmonellaTyphimurium–infected macrophages by impairing antioxidative stress responses

(2017) Nina Judith Hos et al.   JOURNAL OF CELL BIOLOGY

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Superoxide-responsive gene expression in Arabidopsis thaliana and Zea mays

(2017) Junhuan Xu et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Mitochondrial Complex II: At the Crossroads

(2017) Ayenachew Bezawork-Geleta et al.   TRENDS IN BIOCHEMICAL SCIENCES

A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling

(2017) Jemma Gatliff et al.   Cell Death & Disease

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

(2017) Eunice E. To et al.   Nature Communications

Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

(2017) Sabrina Heinz et al.   Scientific Reports

Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice

(2017) Catia C. F. Bernardy et al.   Biomed Research International

Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease

(2017) Filippo Scialò et al.   Frontiers in Physiology

Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

(2017) Thomas Briston et al.   Scientific Reports

Protein Thiol Redox Signaling in Monocytes and Macrophages

(2016) John D. Short et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress and antioxidants: Distress or eustress ?

(2016) Etsuo Niki   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Therapeutic potential of NADPH oxidase 1/4 inhibitors

(2016) G Teixeira et al.   BRITISH JOURNAL OF PHARMACOLOGY

Superoxide Ion: Generation and Chemical Implications

(2016) Maan Hayyan et al.   CHEMICAL REVIEWS

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

(2016) Narciso Couto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

(2016) Yuhui Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Acute respiratory distress syndrome

(2016) Rob Mac Sweeney et al.   LANCET

Adaptive homeostasis

(2016) Kelvin J.A. Davies   MOLECULAR ASPECTS OF MEDICINE

ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy

(2016) Terytty Yang Li et al.   MOLECULAR CELL

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

(2016) Johan Garaude et al.   NATURE IMMUNOLOGY

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Extracellular Redox Regulation of Intracellular Reactive Oxygen Generation, Mitochondrial Function and Lipid Turnover in Cultured Human Adipocytes

(2016) Albert R. Jones IV et al.   PLoS One

Alternative Oxidase Pathway Optimizes Photosynthesis During Osmotic and Temperature Stress by Regulating Cellular ROS, Malate Valve and Antioxidative Systems

(2016) Challabathula Dinakar et al.   Frontiers in Plant Science

Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase

(2016) Dragana Odobasic et al.   Journal of Immunology Research

Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state

(2016) Silvia Cellone Trevelin et al.   Scientific Reports

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

Cytochrome P450s: Mechanisms and Biological Implications in Drug Metabolism and its Interaction with Oxidative Stress

(2015) Sudip Bhattacharyya et al.   CURRENT DRUG METABOLISM

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

The basics of thiols and cysteines in redox biology and chemistry

(2015) Leslie B. Poole   FREE RADICAL BIOLOGY AND MEDICINE

Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice

(2015) Ahmed Bettaieb et al.   GASTROENTEROLOGY

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

(2015) Beth Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRISPR, the disruptor

(2015) Heidi Ledford   NATURE

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

(2015) Jing Geng et al.   NATURE IMMUNOLOGY

The Endoplasmic Reticulum Stress Sensor Inositol-Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production

(2015) Basel H. Abuaita et al.   mBio

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

(2015) Annette Ives et al.   Nature Communications

Disulfide-Mediated Stabilization of the IκB Kinase Binding Domain of NF-κB Essential Modulator (NEMO)

(2014) Li Zhou et al.   BIOCHEMISTRY

The xanthine oxidase-NFAT5 pathway regulates macrophage activation and TLR-induced inflammatory arthritis

(2014) Nam-Hoon Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NADPH Oxidase Modifies Patterns of MHC Class II-Restricted Epitopic Repertoires through Redox Control of Antigen Processing

(2014) E. R. O. Allan et al.   JOURNAL OF IMMUNOLOGY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide

(2014) Yulia G. Ermakova et al.   Nature Communications

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress

(2013) Rafal R. Nazarewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited

(2013) J. David Lambeth et al.   Annual Review of Pathology-Mechanisms of Disease

Mucosal Reactive Oxygen Species Are Required for Antiviral Response: Role of Duox in Influenza A Virus Infection

(2013) Monika Strengert et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanisms of superoxide production by complex III: A bacterial versus human mitochondrial comparative case study

(2013) Pascal Lanciano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reactive oxygen species at phospholipid bilayers: Distribution, mobility and permeation

(2013) Rodrigo M. Cordeiro   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide

(2013) Gerd P. Bienert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Cysteine and Cysteine-Related Signaling Pathways in Arabidopsis thaliana

(2013) Luis C. Romero et al.   Molecular Plant

Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants

(2013) Borut Poljsak et al.   Oxidative Medicine and Cellular Longevity

Reactive Oxygen Species and the Cardiovascular System

(2013) Yannick J. H. J. Taverne et al.   Oxidative Medicine and Cellular Longevity

The Role of Mitochondria-Derived Reactive Oxygen Species in Hyperthermia-Induced Platelet Apoptosis

(2013) Zhicheng Wang et al.   PLoS One

The role of hyperoxia in the pathogenesis of experimental BPD

(2013) Bradley W. Buczynski et al.   SEMINARS IN PERINATOLOGY

HyPer-3: A Genetically Encoded H2O2 Probe with Improved Performance for Ratiometric and Fluorescence Lifetime Imaging

(2012) Dmitry S. Bilan et al.   ACS Chemical Biology

The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation

(2012) David E. Green et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Redox Reactions and Microbial Killing in the Neutrophil Phagosome

(2012) Christine C. Winterbourn et al.   ANTIOXIDANTS & REDOX SIGNALING

A key role for Mg2+in TRPM7's control of ROS levels during cell stress

(2012) Hsiang-Chin Chen et al.   BIOCHEMICAL JOURNAL

Superoxide generation by complex III: From mechanistic rationales to functional consequences

(2012) Lea Bleier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

(2012) Sebastian Altenhöfer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

(2012) A.-B. Al-Mehdi et al.   Science Signaling

A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis

(2011) Stephanie Carnesecchi et al.   ANTIOXIDANTS & REDOX SIGNALING

Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors

(2011) Francesca Gaggini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

NOX1, 2, 4, 5: counting out oxidative stress

(2011) K Wingler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nitric oxide and redox mechanisms in the immune response

(2011) David A. Wink et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Listeria monocytogenestransiently alters mitochondrial dynamics during infection

(2011) Fabrizia Stavru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen Peroxide Promotes Injury-Induced Peripheral Sensory Axon Regeneration in the Zebrafish Skin

(2011) Sandra Rieger et al.   PLOS BIOLOGY

Ce-Duox1/BLI-3 Generated Reactive Oxygen Species Trigger Protective SKN-1 Activity via p38 MAPK Signaling during Infection in C. elegans

(2011) Ransome van der Hoeven et al.   PLoS Pathogens

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

(2010) Anna E. Dikalova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A genetically encoded sensor for H2O2 with expanded dynamic range

(2010) Kseniya N. Markvicheva et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals

(2010) Jesús Aguirre et al.   FREE RADICAL BIOLOGY AND MEDICINE

Urothelial cells produce hydrogen peroxide through the activation of Duox1

(2010) Ágnes Donkó et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state

(2010) Judy Choi et al.   GLIA

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice

(2009) Stéphanie Carnesecchi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondrial Reactive Oxygen Species Production in Excitable Cells: Modulators of Mitochondrial and Cell Function

(2009) David F. Stowe et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of human vascular NADPH oxidase by apocynin derived oligophenols

(2009) Mauricio Mora-Pale et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca2+ pump

(2009) T Tazzeo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

Hydrogen peroxide is the major oxidant product of xanthine oxidase

(2009) Eric E. Kelley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ce-Duox1/BLI-3 Generates Reactive Oxygen Species as a Protective Innate Immune Mechanism in Caenorhabditis elegans

(2009) V. Chavez et al.   INFECTION AND IMMUNITY

Proximity-based Protein Thiol Oxidation by H2O2-scavenging Peroxidases

(2009) Marcus Gutscher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxic stress-induced changes in adrenergic function: role � of HIF1α

(2009) T. C. Tai et al.   JOURNAL OF NEUROCHEMISTRY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Phagocytic Superoxide Specifically Damages an Extracytoplasmic Target to Inhibit or Kill Salmonella

(2009) Maureen Craig et al.   PLoS One

Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347

(2008) Melanie Herscovitch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Redox compartmentalization in eukaryotic cells

(2008) Young-Mi Go et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific

(2008) Elisabetta Aldieri et al.   CURRENT DRUG METABOLISM

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

NOX enzymes as novel targets for drug development

(2008) J. David Lambeth et al.   Seminars in Immunopathology

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION