ROS in cancer therapy: the bright side of the moon

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

(2019) Luca Lignitto et al.   CELL

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

(2019) Clotilde Wiel et al.   CELL

Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

(2018) Rodrigo Prieto-Bermejo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Bisphenol A suppresses proliferation and induces apoptosis in colonic epithelial cells through mitochondrial and MAPK/AKT pathways

(2018) Wei Qu et al.   LIFE SCIENCES

Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

(2018) Hai Wang et al.   Nature Communications

A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells

(2018) Maiara de S. Oliveira et al.   Redox Biology

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

Reactive Oxygen Species-Mediated Mechanisms of Action of Targeted Cancer Therapy

(2017) Hanna-Riikka Teppo et al.   Oxidative Medicine and Cellular Longevity

High-coverage methylation data of a gene model before and after DNA damage and homologous repair

(2017) Antonio Pezone et al.   Scientific Data

Peroxiredoxins in Regulation of MAPK Signalling Pathways; Sensors and Barriers to Signal Transduction

(2016)   MOLECULES AND CELLS

NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis

(2016) Hui Wang et al.   Science Translational Medicine

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

(2016) Youngtae Jeong et al.   Cancer Discovery

Erlotinib induces the human non-small-cell lung cancer cells apoptosis via activating ROS-dependent JNK pathways

(2016) Fenglian Shan et al.   Cancer Medicine

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy

(2015) M. C. Caino et al.   CLINICAL CANCER RESEARCH

The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1

(2015) Sue Goo Rhee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exploring oxidative modifications of tyrosine: An update on mechanisms of formation, advances in analysis and biological consequences

(2015) C. Houée-Lévin et al.   FREE RADICAL RESEARCH

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Interferon gamma/NADPH oxidase defense system in immunity and cancer

(2015) Zdenek Hodny et al.   OncoImmunology

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

Phosphorylation of H3 serine 10 by IKKα governs cyclical production of ROS in estrogen-induced transcription and ensures DNA wholeness

(2014) B Perillo et al.   CELL DEATH AND DIFFERENTIATION

Investigational cancer drugs targeting cell metabolism in clinical development

(2014) Douglas W Sborov et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation

(2014) L. Wang et al.   JOURNAL OF IMMUNOLOGY

An overview of mechanisms of redox signaling

(2014) Henry Jay Forman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis

(2014) S. Svegliati et al.   Science Signaling

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

(2014) Chi Kwan Tsang et al.   Nature Communications

Nuclear receptor-induced transcription is driven by spatially and timely restricted waves of ROS

(2014) Bruno Perillo et al.   Nucleus

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

A call to ARMS: targeting thePAX3-FOXO1gene in alveolar rhabdomyosarcoma

(2013) Mary E Olanich et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

(2013) Christophe Louandre et al.   INTERNATIONAL JOURNAL OF CANCER

Novel Phosphorylation and Ubiquitination Sites Regulate Reactive Oxygen Species-dependent Degradation of Anti-apoptotic c-FLIP Protein

(2013) Rachel P. Wilkie-Grantham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

(2013) Chiara Gorrini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells

(2013) Sudjit Luanpitpong et al.   MOLECULAR BIOLOGY OF THE CELL

Redox-Dependent Control of FOXO/DAF-16 by Transportin-1

(2013) Marrit Putker et al.   MOLECULAR CELL

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene

(2013) A. Morano et al.   NUCLEIC ACIDS RESEARCH

Correction: High Weight Loss during Radiation Treatment Changes the Prognosis in Under-/Normal Weight Nasopharyngeal Carcinoma Patients for the Worse: A Retrospective Analysis of 2433 Cases

(2013) Lu-Jun Shen et al.   PLoS One

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

(2012) Shouji Matsushima et al.   CIRCULATION RESEARCH

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

(2012) Lin Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence

(2012) Ryo Kodama et al.   GENES TO CELLS

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

(2012) Sandra Misale et al.   NATURE

Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

(2012) Arya Sobhakumari et al.   PLoS One

Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors

(2011) Thomas De Raedt et al.   CANCER CELL

Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells

(2011) Qi Zhang et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Highlighting chromosome loops in DNA-picked chromatin (DPC)

(2011) Ciro Abbondanza et al.   Epigenetics

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells

(2011) Shao-Ping Chang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

(2011) A. T. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Preclinical Characterization of Mitochondria-Targeted Small Molecule Hsp90 Inhibitors, Gamitrinibs, in Advanced Prostate Cancer

(2010) B. H. Kang et al.   CLINICAL CANCER RESEARCH

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

(2010) Z. K. Pinnix et al.   Science Translational Medicine

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1

(2009) Yong Zuo et al.   CELL RESEARCH

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The x c − cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine

(2008) Jun Guan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Reactive oxygen species in tumor metastasis

(2008) Makiya Nishikawa   CANCER LETTERS

NOV-002, a Glutathione Disulfide Mimetic, as a Modulator of Cellular Redox Balance

(2008) D. M. Townsend et al.   CANCER RESEARCH

Necroptosis: A Specialized Pathway of Programmed Necrosis

(2008) Lorenzo Galluzzi et al.   CELL

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A new APE1/Ref-1-dependent pathway leading to reduction of NF- B and AP-1, and activation of their DNA-binding activity

(2008) K. Ando et al.   NUCLEIC ACIDS RESEARCH

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

(2008) S. Rottenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression

(2008) B. Perillo et al.   SCIENCE