ROS and ROS-Mediated Cellular Signaling

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

(2015) Giampaolo Morciano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Redox Signaling Pathways Involved in Neuronal Ischemic Preconditioning

(2015) John W. Thompson et al.   Current Neuropharmacology

Redox Regulation of Ion Channels

(2014) Ivan Bogeski et al.   ANTIOXIDANTS & REDOX SIGNALING

PI3K/Akt-mediated regulation of p53 in cancer

(2014) Aswin G. Abraham et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial production of reactive oxygen species

(2014) V. G. Grivennikova et al.   BIOCHEMISTRY-MOSCOW

TNF- -mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes

(2014) S. Roberge et al.   CARDIOVASCULAR RESEARCH

How to win ATP and influence Ca2+ signaling

(2014) Svetlana Voronina et al.   CELL CALCIUM

Pathogenesis of Human Mitochondrial Diseases Is Modulated by Reduced Activity of the Ubiquitin/Proteasome System

(2014) Alexandra Segref et al.   Cell Metabolism

Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets

(2014) Ian P Harrison et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

COX2 and PGE2 mediate EGF-induced E-cadherin-independent human ovarian cancer cell invasion

(2014) Xin Qiu et al.   ENDOCRINE-RELATED CANCER

Regulation of the Skeletal Muscle Ryanodine Receptor/Ca2+-release Channel RyR1 byS-Palmitoylation

(2014) Ruchi Chaube et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione Adducts on Sarcoplasmic/Endoplasmic Reticulum Ca2+ATPase Cys-674 Regulate Endothelial Cell Calcium Stores and Angiogenic Function as Well as Promote Ischemic Blood Flow Recovery

(2014) Melissa D. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase D activity controls endothelial nitric oxide synthesis

(2014) Clara Aicart-Ramos et al.   JOURNAL OF CELL SCIENCE

Ca2+–CaM regulating viability of Candida guilliermondii under oxidative stress by acting on detergent resistant membrane proteins

(2014) Bang An et al.   Journal of Proteomics

Astaxanthin Alleviates Early Brain Injury Following Subarachnoid Hemorrhage in Rats: Possible Involvement of Akt/Bad Signaling

(2014) Xiang-Sheng Zhang et al.   Marine Drugs

Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production

(2014) Lawrence O. Olala et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Disruption of Interleukin-1β Autocrine Signaling Rescues Complex I Activity and Improves ROS Levels in Immortalized Epithelial Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function

(2014) Mariángeles Clauzure et al.   PLoS One

Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca2+ Oscillations, Store-Operated Ca2+ Entry and Ca2+-Dependent Gene Expression in Response to Receptor Stimulation

(2014) Krishna Samanta et al.   PLoS One

A non-linear detection of phospho-histone H2AX in EA.hy926 endothelial cells following low-dose X-irradiation is modulated by reactive oxygen species

(2014) Martin Large et al.   Radiation Oncology

Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-κB activation via a negative feedback loop

(2014) T Elmetwali et al.   Cell Death & Disease

Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system

(2014) Gang Li et al.   Neuroscience Bulletin

Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures

(2014) Sandra Gardam et al.   Frontiers in Immunology

Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition

(2014) Minsoo Kim et al.   Cells

Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII

(2013) Can M. Sag et al.   BASIC RESEARCH IN CARDIOLOGY

Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice

(2013) Motohiro Nishida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIV protease inhibitors and onset of cardiovascular diseases: A central role for oxidative stress and dysregulation of the ubiquitin–proteasome system

(2013) Kathleen M.S.E. Reyskens et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PKA: Lessons learned after twenty years

(2013) Susan S. Taylor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mitochondrial Colocalization with Ca2+ Release Sites is Crucial to Cardiac Metabolism

(2013) Asuka Hatano et al.   BIOPHYSICAL JOURNAL

PKC signaling in glioblastoma

(2013) Anália do Carmo et al.   CANCER BIOLOGY & THERAPY

ROS regulation of microdomain Ca2+ signalling at the dyads

(2013) Huiliang Zhang et al.   CARDIOVASCULAR RESEARCH

Multi-level control of actin dynamics by protein kinase D

(2013) Monilola A. Olayioye et al.   CELLULAR SIGNALLING

New insights in regulation of calcium homeostasis

(2013) Arnold Felsenfeld et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans

(2013) Gilles Gouspillou et al.   FASEB JOURNAL

The plasma membrane calcium pump in health and disease

(2013) Marisa Brini et al.   FEBS Journal

Folic acid reverses nitric oxide synthase uncoupling and prevents cardiac dysfunction in insulin resistance: Role of Ca2+/calmodulin-activated protein kinase II

(2013) Nathan D. Roe et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes

(2013) Can M. Sag et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species and the free radical theory of aging

(2013) Stefan I. Liochev   FREE RADICAL BIOLOGY AND MEDICINE

Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival

(2013) Abasha Lewis et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The Keap1/Nrf2 Protein Axis Plays a Role in Osteoclast Differentiation by Regulating Intracellular Reactive Oxygen Species Signaling

(2013) Hiroyuki Kanzaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory Signalings Involved in Airway and Pulmonary Diseases

(2013) I-Ta Lee et al.   MEDIATORS OF INFLAMMATION

p120 catenin is a key effector of a Ras-PKCɛ oncogenic signaling axis

(2013) S G Dann et al.   ONCOGENE

Adenine Nucleotide Translocase, Mitochondrial Stress, and Degenerative Cell Death

(2013) Yaxin Liu et al.   Oxidative Medicine and Cellular Longevity

Reactive Oxygen Species Are Required for 5-HT-Induced Transactivation of Neuronal Platelet-Derived Growth Factor and TrkB Receptors, but Not for ERK1/2 Activation

(2013) Jeff S. Kruk et al.   PLoS One

Keap1 redox-dependent regulation of doxorubicin-induced oxidative stress response in cardiac myoblasts

(2013) Kendra K.S. Nordgren et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ROS production as a common mechanism of ENaC regulation by EGF, insulin, and IGF-1

(2012) Daria V. Ilatovskaya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The ubiquitin proteasome system and myocardial ischemia

(2012) Justine Calise et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Redox Regulation of Sodium and Calcium Handling

(2012) Stefan Wagner et al.   ANTIOXIDANTS & REDOX SIGNALING

Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

(2012) Clare Davies et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL

(2012) Hui Tian et al.   CANCER LETTERS

Regulation of ATP production by mitochondrial Ca2+

(2012) Andrei I. Tarasov et al.   CELL CALCIUM

Lymphotoxin, NF-?B, and Cancer: The Dark Side of Cytokines

(2012) Judith Bauer et al.   DIGESTIVE DISEASES

Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer

(2012) Albert S. Baldwin   IMMUNOLOGICAL REVIEWS

Ca2+-dependent Transcriptional Control of Ca2+Homeostasis

(2012) Jose R. Naranjo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species in Health and Disease

(2012) Assim A. Alfadda et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration

(2012) Y.-D. Kwak et al.   JOURNAL OF NEUROSCIENCE

Human T Cell Leukemia Virus Type 2 Tax-Mediated NF- B Activation Involves a Mechanism Independent of Tax Conjugation to Ubiquitin and SUMO

(2012) C. Journo et al.   JOURNAL OF VIROLOGY

A cytokine axis regulates elastin formation and degradation

(2012) Erin P. Sproul et al.   MATRIX BIOLOGY

Protection against oxidative DNA damage and stress in human prostate by glutathioneS-transferase P1

(2012) Rajnee Kanwal et al.   MOLECULAR CARCINOGENESIS

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Oxidation matters: The ubiquitin proteasome system connects innate immune mechanisms with MHC class I antigen presentation

(2012) Annika Warnatsch et al.   MOLECULAR IMMUNOLOGY

Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

(2012) Margarida Castro-Caldas et al.   MOLECULAR NEUROBIOLOGY

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Upregulation of Stromal Cell-Derived Factor By IL-17 and IL-18 Via a Phosphatidylinositol 3-Kinase-Dependent Pathway

(2012) I. E. Ahn et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

A ROS rheostat for cell fate regulation

(2012) Maria Maryanovich et al.   TRENDS IN CELL BIOLOGY

Complex I deficiencies in neurological disorders

(2012) Sergio Papa et al.   TRENDS IN MOLECULAR MEDICINE

A New View of the Lethal Apoptotic Pore

(2012) Gorka Basañez et al.   PLOS BIOLOGY

Preconditioning tachycardia decreases the activity of the mitochondrial permeability transition pore in the dog heart

(2011) Gina Sánchez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of VDAC in cell death: Friend or foe?

(2011) Kyle S. McCommis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

FoxO family members in cancer

(2011) Yuqing Zhang et al.   CANCER BIOLOGY & THERAPY

Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and β-catenin and enhances invasion in nasopharyngeal carcinoma cells

(2011) Wai Kien Yip et al.   CANCER LETTERS

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

(2011) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Respiratory chain complex I, a main regulatory target of the cAMP/PKA pathway is defective in different human diseases

(2011) Sergio Papa et al.   FEBS LETTERS

Superoxide dismutases: Ancient enzymes and new insights

(2011) Anne-Frances Miller   FEBS LETTERS

Redox activity of α-synuclein–Cu is silenced by Zn7-metallothionein-3

(2011) Gabriele Meloni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ubiquitin–proteasome pathway and cellular responses to oxidative stress

(2011) Fu Shang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Enteric Commensal Bacteria Induce Extracellular Signal-regulated Kinase Pathway Signaling via Formyl Peptide Receptor-dependent Redox Modulation of Dual Specific Phosphatase 3

(2011) Christy C. Wentworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

Ethanol-induced oxidative stress is associated with EGF receptor phosphorylation in MCF-10A cells overexpressing CYP2E1

(2011) Angel León-Buitimea et al.   TOXICOLOGY LETTERS

The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

(2010) Anatoly A. Starkov   Annals of the New York Academy of Sciences

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Partial unfolding and oligomerization of stromal interaction molecules as an initiation mechanism of store operated calcium entryThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.

(2010) Peter B. Stathopulos et al.   Biochemistry and Cell Biology

The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation

(2010) Alexander Plotnikov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5

(2010) Augusto C. Montezano et al.   CLINICAL SCIENCE

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration

(2010) Csaba Konràd et al.   FEBS Journal

Calcium sensitivity, force frequency relationship and cardiac troponin I: Critical role of PKA and PKC phosphorylation sites

(2010) Genaro A. Ramirez-Correa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Multistep and multitask Bax activation

(2010) Lina Ghibelli et al.   MITOCHONDRION

The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants

(2010) Kyeong-Ah Jung et al.   MOLECULES

Ca2+ signaling and STIM1

(2010) Tomohiro Kurosaki et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-κB activation

(2010) Yoon-Jae Song et al.   VIRUS GENES

Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation

(2009) Geoffrey Gloire et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt

(2009) Ki Cheon Kim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Growth Factors Outside of the Platelet-derived Growth Factor (PDGF) Family Employ Reactive Oxygen Species/Src Family Kinases to Activate PDGF Receptor α and Thereby Promote Proliferation and Survival of Cells

(2009) Hetian Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling

(2009) C. F. Cowell et al.   JOURNAL OF CELL SCIENCE

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial gateways to cancer

(2009) Lorenzo Galluzzi et al.   MOLECULAR ASPECTS OF MEDICINE

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects

(2008) Keir J. Menzies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypothermic Injury: the Mitochondrial Calcium, ATP and ROS Love-Hate Triangle out of Balance

(2008) Paul-Thomas Brinkkoetter et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Advances in Targeting the Ras/Raf/MEK/Erk Mitogen-Activated Protein Kinase Cascade with MEK Inhibitors for Cancer Therapy

(2008) B. B. Friday et al.   CLINICAL CANCER RESEARCH

Crosstalk via the NF-κB signaling system

(2008) Soumen Basak et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The non-provitamin A carotenoid, lutein, inhibits NF-κB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-κB-inducing kinase pathways: Role of H2O2 in NF-κB activation

(2008) Ji-Hee Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Ca2+Mobilization

(2008) MIKLÓS MÁNDI et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL

PKC signaling in oxidative hepatic damage

(2007) Mariapaola Nitti et al.   MOLECULAR ASPECTS OF MEDICINE