Chalcone suppresses tumor growth through NOX4-IRE1α sulfonation-RIDD-miR-23b axis

Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death

(2019) Lorenzo Sansalone et al.   Cancers

The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells

(2019) Karim Bahmed et al.   Cell Death & Disease

Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in HypertensionNovelty and Significance

(2018) Livia L. Camargo et al.   HYPERTENSION

Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress

(2017) Baran A. Ersoy et al.   JOURNAL OF CLINICAL INVESTIGATION

A synthetic chalcone, 2'-hydroxy-2,3,5'-trimethoxychalcone triggers unfolded protein response-mediated apoptosis in breast cancer cells

(2016) Da Hyun Lee et al.   CANCER LETTERS

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

(2016) S. Sahoo et al.   CLINICAL SCIENCE

Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs

(2016) Jie-Mei Wang et al.   DIABETES

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response

(2016) John M. Hourihan et al.   MOLECULAR CELL

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Role of redoximiRs in fibrogenesis

(2016) Marta Fierro-Fernández et al.   Redox Biology

Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death

(2015) Nobuhiko Hiramatsu et al.   AMERICAN JOURNAL OF PATHOLOGY

Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks

(2015) Neal S. Gould et al.   CHEMISTRY & BIOLOGY

The synthetic compound 2′-hydroxy-2,4,6′-trimethoxychalcone overcomes P-glycoprotein-mediated multi-drug resistance in drug-resistant uterine sarcoma MES-SA/DX5 cells

(2015) Soon Young Shin et al.   Journal of the Korean Society for Applied Biological Chemistry

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

(2015) L. Yang et al.   SCIENCE

The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function

(2015) Philip A. Kramer et al.   Frontiers in Physiology

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

Endoplasmic reticulum stress and endothelial dysfunction

(2014) Stefania Lenna et al.   IUBMB LIFE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Site-specific mapping and quantification of protein S-sulphenylation in cells

(2014) Jing Yang et al.   Nature Communications

Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD

(2014) Arvin B. Tam et al.   Cell Reports

Endoplasmic reticulum stress signaling: the microRNA connection

(2013) Marion Maurel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Novel Antimitotic Activity of 2-Hydroxy-4-methoxy-2′,3′-benzochalcone (HymnPro) through the Inhibition of Tubulin Polymerization

(2013) Soon Young Shin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

IRE1, a Double-Edged Sword in Pre-miRNA Slicing and Cell Death

(2012) Justin Hassler et al.   DEVELOPMENTAL CELL

MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response

(2012) Andrew E. Byrd et al.   JOURNAL OF CELL BIOLOGY

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer

(2012) S-F Su et al.   ONCOGENE

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord

(2012) Y B Im et al.   Cell Death & Disease

Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders

(2011) Lale Ozcan et al.   Annual Review of Medicine

A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis

(2011) Stephanie Carnesecchi et al.   ANTIOXIDANTS & REDOX SIGNALING

Dietary chalcones with chemopreventive and chemotherapeutic potential

(2011) Barbora Orlikova et al.   Genes and Nutrition

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

(2011) Fanjun Meng et al.   Molecular Neurodegeneration

Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein

(2011) J. Maiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

(2011) A. Parkhitko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PC3 is a cell line characteristic of prostatic small cell carcinoma

(2011) Sheng Tai et al.   PROSTATE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Endoplasmic reticulum associated protein degradation: A chaperone assisted journey to hell

(2010) Alexandra Stolz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation

(2010) R.-F. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders

(2009) Miao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural Antitumoral Activity Relationships of Synthetic Chalcones

(2009) Cesar Echeverria et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bax Inhibitor-1 Is a pH-dependent Regulator of Ca2+Channel Activity in the Endoplasmic Reticulum

(2008) Hyung-Ryong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY