NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis

(2020) Pan Luo et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Obesity a Risk Factor for Severe COVID-19 Infection: Multiple Potential Mechanisms

(2020) Naveed Sattar et al.   CIRCULATION

Angiotensin Converting Enzyme 2: A Double-Edged Sword

(2020) Kaiming Wang et al.   CIRCULATION

COVID-19 and Multiorgan Response

(2020) Sevim Zaim et al.   CURRENT PROBLEMS IN CARDIOLOGY

DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)–Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1–Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway

(2020) Kosuke Okabe et al.   HYPERTENSION

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19 and cardiovascular injury: A role for oxidative stress and antioxidant treatment?

(2020) Lorenzo Loffredo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19)

(2020) Pere Domingo et al.   EBioMedicine

Metabolism Regulation and Redox State: Insight into the Role of Superoxide Dismutase 1

(2020) Simona Damiano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

(2020) Rubens Cecchini et al.   MEDICAL HYPOTHESES

Can Activation of NRF2 Be a Strategy against COVID-19?

(2020) Antonio Cuadrado et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

(2020) David Olagnier et al.   Nature Communications

Nox2 activation in Covid-19

(2020) Francesco Violi et al.   Redox Biology

The Role of NADPH oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology

(2019) Evan DeVallance et al.   ANTIOXIDANTS & REDOX SIGNALING

Endothelial Dysfunction: Is There a Hyperglycemia-Induced Imbalance of NOX and NOS?

(2019) Cesar A. Meza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual Role of Reactive Oxygen Species in Muscle Function: Can Antioxidant Dietary Supplements Counteract Age-Related Sarcopenia?

(2019) Simona Damiano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The proinflammatory effects of macrophage-derived NADPH oxidase function in autoimmune diabetes

(2018) Joseph M. Feduska et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metformin: Prevention of genomic instability and cancer: A review

(2018) Masoud Najafi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Quercetin Increases MUC2 and MUC5AC Gene Expression and Secretion in Intestinal Goblet Cell-Like LS174T via PLC/PKCα/ERK1-2 Pathway

(2018) Simona Damiano et al.   Frontiers in Physiology

The natural phenolic compounds as modulators of NADPH oxidases in hypertension

(2018) Mozhdeh Yousefian et al.   PHYTOMEDICINE

Redox Biology of Respiratory Viral Infections

(2018) Olga Khomich et al.   Viruses-Basel

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

(2017) Eunice E. To et al.   Nature Communications

New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 IndividualsCLINICAL PERSPECTIVE

(2017) Aldi T. Kraja et al.   Circulation-Cardiovascular Genetics

Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in ObesityHighlights

(2016) Laura J. Den Hartigh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

(2016) S. Sahoo et al.   CLINICAL SCIENCE

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

Dual oxidase 2 generated reactive oxygen species selectively mediate the induction of mucins by epidermal growth factor in enterocytes

(2015) Simona Damiano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Angiotensin Converting Enzyme 2/Ang-(1-7)/Mas Axis Protects Brain from Ischemic Injury with a Tendency of Age-dependence

(2014) Jiao-Lin Zheng et al.   CNS Neuroscience & Therapeutics

ROS upregulation during the early phase of retroviral infection plays an important role in viral establishment in the host cell

(2013) S. J. Kim et al.   JOURNAL OF GENERAL VIROLOGY

Cu–Zn superoxide dismutase activates muscarinic acetylcholine M1 receptor pathway in neuroblastoma cells

(2012) Simona Damiano et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Rhinovirus-Induced Barrier Dysfunction in Polarized Airway Epithelial Cells Is Mediated by NADPH Oxidase 1

(2011) A. T. Comstock et al.   JOURNAL OF VIROLOGY

Oxidative Stress and Insulin Resistance: The Coronary Artery Risk Development in Young Adults study

(2009) K. Park et al.   DIABETES CARE