Therapeutic potential of NADPH oxidase 1/4 inhibitors

Unchanged NADPH Oxidase Activity in Nox1-Nox2-Nox4 Triple Knockout Mice: What Do NADPH-Stimulated Chemiluminescence Assays Really Detect?

(2016) Flávia Rezende et al.   ANTIOXIDANTS & REDOX SIGNALING

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor

(2015) Kazufumi Hirano et al.   ANTIOXIDANTS & REDOX SIGNALING

NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?

(2015) Christine Hirschhäuser et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of NADPH Oxidase-4 Potentiates 2-Deoxy-d-Glucose-Induced Suppression of Glycolysis, Migration, and Invasion in Glioblastoma Cells: Role of the Akt/HIF1α/HK-2 Signaling Axis

(2015) Priyanka Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Overview

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NF B Signaling Pathways

(2015) Q. D. Zhao et al.   CIRCULATION

NADPH oxidases and cancer

(2015) Krishnendu Roy et al.   CLINICAL SCIENCE

The NADPH oxidase Nox4 has anti-atherosclerotic functions

(2015) Christoph Schürmann et al.   EUROPEAN HEART JOURNAL

A subset of N-substituted phenothiazines inhibits NADPH oxidases

(2015) Tamara Seredenina et al.   FREE RADICAL BIOLOGY AND MEDICINE

The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice

(2015) E. Anvari et al.   FREE RADICAL RESEARCH

Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice

(2015) Ahmed Bettaieb et al.   GASTROENTEROLOGY

NADPH Oxidase-generated Hydrogen Peroxide Induces DNA Damage in Mutant FLT3-expressing Leukemia Cells

(2015) Joanna Stanicka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients

(2015) Lisa M. Rice et al.   JOURNAL OF CLINICAL INVESTIGATION

Premature Skin Aging Features Rescued by Inhibition of NADPH Oxidase Activity in XPC-Deficient Mice

(2015) Mohsen Hosseini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina

(2015) Devy Deliyanti et al.   Journal of Neuroinflammation

Nox4 supports proper capillary growth in exercise and retina neo-vascularization

(2015) Juri Vogel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

(2015) Y.-H. You et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells

(2015) A K Jayavelu et al.   LEUKEMIA

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

Measurement of Long-Range Angular Correlation and Quadrupole Anisotropy of Pions and (Anti)Protons in Centrald+AuCollisions atsNN=200GeV

(2015) A. Adare et al.   PHYSICAL REVIEW LETTERS

NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer

(2015) Xiyu Liu et al.   TUMOR BIOLOGY

NADPH Oxidase 4-Derived H2O2Promotes Aberrant Retinal Neovascularization via Activation of VEGF Receptor 2 Pathway in Oxygen-Induced Retinopathy

(2015) Jingming Li et al.   Journal of Diabetes Research

Increased Expression of NAPDH Oxidase 4 in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor β

(2015) Sonsoles Piera-Velazquez et al.   Arthritis & Rheumatology

A Reactive Oxygen Species-Mediated Loop Maintains Increased Expression of NADPH Oxidases 2 and 4 in Skin Fibroblasts From Patients With Systemic Sclerosis

(2015) Tatiana Spadoni et al.   Arthritis & Rheumatology

Genetic disorders coupled to ROS deficiency

(2015) Sharon O’Neill et al.   Redox Biology

Role of Neuronal NADPH Oxidase 1 in the Peri-Infarct Regions after Stroke

(2015) Dong-Hee Choi et al.   PLoS One

NOX1 Supports the Metabolic Remodeling of HepG2 Cells

(2015) Katharina Bertram et al.   PLoS One

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

(2015) Tian Lan et al.   PLoS One

Updates of reactive oxygen species in melanoma etiology and progression

(2014) Feng Liu-Smith et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NADPH Oxidase 4 Is Expressed in Pulmonary Artery Adventitia and Contributes to Hypertensive Vascular Remodeling

(2014) Scott A. Barman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ROS signalling, NADPH oxidases and cancer: Figure 1

(2014) William D. Landry et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells

(2014) H E Boudreau et al.   BRITISH JOURNAL OF CANCER

NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2 

(2014) J. L. Gregg et al.   CANCER RESEARCH

NADPH Oxidases as Therapeutic Targets in Chronic Myelogenous Leukemia

(2014) B. Sanchez-Sanchez et al.   CLINICAL CANCER RESEARCH

Is Nox4 a key regulator of the activated state of fibroblasts in systemic sclerosis?

(2014) Markus Böhm et al.   EXPERIMENTAL DERMATOLOGY

Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells

(2014) Filippo Zanetti et al.   FREE RADICAL BIOLOGY AND MEDICINE

The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression

(2014) Eva Crosas-Molist et al.   FREE RADICAL BIOLOGY AND MEDICINE

NOX1 deficiency in apolipoprotein E-knockout mice is associated with elevated plasma lipids and enhanced atherosclerosis

(2014) C. G. Sobey et al.   FREE RADICAL RESEARCH

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

(2014) J. C. Jha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis

(2014) Bogna Grygiel-Górniak et al.   MEDIATORS OF INFLAMMATION

Lentivirus-Mediated Nox4 shRNA Invasion and Angiogenesis and Enhances Radiosensitivity in Human Glioblastoma

(2014) Yongsheng Li et al.   Oxidative Medicine and Cellular Longevity

Induction of Cancer Stem Cell Properties in Colon Cancer Cells by Defined Factors

(2014) Nobu Oshima et al.   PLoS One

Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice

(2014) Xavier Tréton et al.   PLoS One

NOX4 Mediates BMP4-Induced Upregulation of TRPC1 and 6 Protein Expressions in Distal Pulmonary Arterial Smooth Muscle Cells

(2014) Qian Jiang et al.   PLoS One

Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death through Nox1-Regenerated Oxidative Stress

(2014) Dong-Hee Choi et al.   PLoS One

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Physiological and pathological functions of NADPH oxidases during myocardial ischemia–reperfusion

(2014) Shouji Matsushima et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Site-specific mapping and quantification of protein S-sulphenylation in cells

(2014) Jing Yang et al.   Nature Communications

Link between PI3K/AKT/PTEN Pathway and NOX Protein in Diseases

(2014) Atsuko Nakanishi   Aging and Disease

Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

(2014) Revati Wani et al.   Frontiers in Pharmacology

Role of NADPH Oxidases in Liver Fibrosis

(2013) Yong-Han Paik et al.   ANTIOXIDANTS & REDOX SIGNALING

Mucosal Reactive Oxygen Species Are Required for Antiviral Response: Role of Duox in Influenza A Virus Infection

(2013) Monika Strengert et al.   ANTIOXIDANTS & REDOX SIGNALING

New Insights on NOX Enzymes in the Central Nervous System

(2013) Zeynab Nayernia et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy

(2013) Jennifer L. Wilkinson-Berka et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents

(2013) Olubukola Babalola et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Deficiency of NOX1/Nicotinamide Adenine Dinucleotide Phosphate, Reduced Form Oxidase Leads to Pulmonary Vascular Remodeling

(2013) Kazumi Iwata et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cancer Stem–like Cell Marker CD44 Promotes Bone Metastases by Enhancing Tumorigenicity, Cell Motility, and Hyaluronan Production

(2013) Toru Hiraga et al.   CANCER RESEARCH

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-inducible Factor-1α and Upregulation of Peroxisome Proliferator–activated Receptor-α

(2013) Shouji Matsushima et al.   CIRCULATION RESEARCH

Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy

(2013) Jennifer L. Wilkinson-Berka et al.   CLINICAL SCIENCE

The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite

(2013) S. Schildknecht et al.   CURRENT MEDICINAL CHEMISTRY

Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe −/− mice

(2013) E. Di Marco et al.   DIABETOLOGIA

The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene

(2013) R. Steven Esworthy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox4 redox regulation of PTP1B contributes to the proliferation and migration of glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C

(2013) Abdus S. Mondol et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

(2013) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

(2013) Claudia Goettsch et al.   JOURNAL OF CLINICAL INVESTIGATION

K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxide

(2013) Richard J. Calvert et al.   LUNG CANCER

TGF-  directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury

(2013) D. M. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From fatty liver to fibrosis: A tale of “second hit”

(2013) Metin Basaranoglu   WORLD JOURNAL OF GASTROENTEROLOGY

Nephrogenic Systemic Fibrosis

(2012) Brent Wagner et al.   AMERICAN JOURNAL OF PATHOLOGY

The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation

(2012) David E. Green et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species

(2012) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

(2012) Marie T. Fischer et al.   BRAIN

Targeting NOX enzymes in pulmonary fibrosis

(2012) Louise Hecker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting NADPH oxidases for the treatment of cancer and inflammation

(2012) Michael Y. Bonner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

(2012) Sebastian Altenhöfer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

(2012) Mona Sedeek et al.   CLINICAL SCIENCE

The ROS-NOX Connection in Cancer and Angiogenesis

(2012) Christophe Blanchetot et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Nox4 in murine models of kidney disease

(2012) Andrea Babelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence

(2012) Ryo Kodama et al.   GENES TO CELLS

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair

(2012) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury

(2012) W. Kallenborn-Gerhardt et al.   JOURNAL OF NEUROSCIENCE

NADPH Oxidase 1 Mediates  -Synucleinopathy in Parkinson's Disease

(2012) A. C. Cristovao et al.   JOURNAL OF NEUROSCIENCE

Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells

(2012) Christine Deffert et al.   JOURNAL OF PATHOLOGY

NADPH-Oxidase 4 Protects against Kidney Fibrosis during Chronic Renal Injury

(2012) S. Nlandu Khodo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NOXious signaling in pain processing

(2012) Wiebke Kallenborn-Gerhardt et al.   PHARMACOLOGY & THERAPEUTICS

Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production

(2012) John P. Fitzgerald et al.   PLoS One

NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

(2012) Patricia Sancho et al.   PLoS One

NADPH Oxidase 4 Mediates Insulin-Stimulated HIF-1α and VEGF Expression, and Angiogenesis In Vitro

(2012) Dan Meng et al.   PLoS One

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

(2012) Weiqin Lu et al.   PLOS BIOLOGY

D469del-COMP Retention in Chondrocytes Stimulates Caspase-Independent Necroptosis

(2011) Françoise Coustry et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Expression Mediates Intrinsic Airway Smooth Muscle Hypercontractility in Asthma

(2011) Amanda Sutcliffe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis

(2011) Stephanie Carnesecchi et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidase 1-Mediated Oxidative Stress Leads to Dopamine Neuron Death in Parkinson's Disease

(2011) Dong-Hee Choi et al.   ANTIOXIDANTS & REDOX SIGNALING

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role for Nox1 NADPH oxidase in atherosclerosis

(2011) Andrea L. Sheehan et al.   ATHEROSCLEROSIS

NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies

(2011) Alexander Sirker et al.   BASIC RESEARCH IN CARDIOLOGY

Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors

(2011) Francesca Gaggini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

(2011) Yong-Han Paik et al.   HEPATOLOGY

Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis

(2011) Bruno Crestani et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation

(2011) Gregory J. Gatto et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Involvement of NOX1/NADPH Oxidase in Morphine-Induced Analgesia and Tolerance

(2011) M. Ibi et al.   JOURNAL OF NEUROSCIENCE

Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR

(2011) Ana M. Briones et al.   Journal of the American Society of Hypertension

Imaging the Impact of Nox4 in Cycling Hypoxia-mediated U87 Glioblastoma Invasion and Infiltration

(2011) Chia-Hung Hsieh et al.   MOLECULAR IMAGING AND BIOLOGY

NOX-4 is expressed in thickened pulmonary arteries in idiopathic pulmonary fibrosis

(2011) Jean-Claude Pache et al.   NATURE MEDICINE

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

NADPH Oxidase Subunit 4-Mediated Reactive Oxygen Species Contribute to Cycling Hypoxia-Promoted Tumor Progression in Glioblastoma Multiforme

(2011) Chia-Hung Hsieh et al.   PLoS One

PPARγ regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-κB

(2010) Xianghuai Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species

(2010) Hamid Reza Rezvani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Nox Activator 1

(2010) Xi-Lin Niu et al.   CIRCULATION

Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein–Induced Macrophage Death

(2010) Chi Fung Lee et al.   CIRCULATION RESEARCH

Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice: Role of NADPH Oxidase 4

(2010) J. Li et al.   DIABETES

NADPH oxidases in cardiovascular disease

(2010) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection

(2010) Nabora Soledad Reyes de Mochel et al.   HEPATOLOGY

NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis

(2010) Aleksandr E. Vendrov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-Molecule Inhibitors of NADPH Oxidase 4

(2010) Gábor Borbély et al.   JOURNAL OF MEDICINAL CHEMISTRY

NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon

(2010) Nicolas Coant et al.   MOLECULAR AND CELLULAR BIOLOGY

Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance

(2010) Tim Doyle et al.   NEUROSCIENCE LETTERS

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts

(2010) N. Amara et al.   THORAX

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Mining the Thiol Proteome for Sulfenic Acid Modifications Reveals New Targets for Oxidation in Cells

(2009) Stephen E. Leonard et al.   ACS Chemical Biology

NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice

(2009) Stéphanie Carnesecchi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Role of NADPH Oxidase 1–Derived Reactive Oxygen Species in Paraquat-Mediated Dopaminergic Cell Death

(2009) Ana Clara Cristóvão et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of Vascular Smooth Muscle NADPH Oxidase 1 (Nox1) Contribution to Injury-Induced Neointimal Formation

(2009) Moo Yeol Lee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH Oxidases: Functions and Pathologies in the Vasculature

(2009) Bernard Lassègue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of Dual Oxidases Duox1 and Duox2

(2009) Sabrina Rigutto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C Virus (HCV) Proteins Induce NADPH Oxidase 4 Expression in a Transforming Growth Factor  -Dependent Manner: a New Contributor to HCV-Induced Oxidative Stress

(2009) H. E. Boudreau et al.   JOURNAL OF VIROLOGY

Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts

(2009) Bruna De Felice et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

(2008) Srikanth Pendyala et al.   ANTIOXIDANTS & REDOX SIGNALING

A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation

(2008) Jin-Gu Lee et al.   CELLULAR SIGNALLING

Reactive Oxygen Species Derived from NOX1/NADPH Oxidase Enhance Inflammatory Pain

(2008) M. Ibi et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

(2008) C. Cheret et al.   JOURNAL OF NEUROSCIENCE

A chemical approach for detecting sulfenic acid-modified proteins in living cells

(2008) Khalilah G. Reddie et al.   Molecular BioSystems

Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6

(2008) Y Adachi et al.   ONCOGENE

Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase

(2008) Michela G. Schäppi et al.   Seminars in Immunopathology