The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)

(2012) Qi-An Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress

(2012) Rosa Bretón-Romero et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis

(2011) Stephanie Carnesecchi et al.   ANTIOXIDANTS & REDOX SIGNALING

Hsp90 Regulates NADPH Oxidase Activity and Is Necessary for Superoxide but Not Hydrogen Peroxide Production

(2011) Feng Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells

(2011) Patricia Sancho et al.   BIOCHEMICAL PHARMACOLOGY

NOX1, 2, 4, 5: counting out oxidative stress

(2011) K Wingler et al.   BRITISH JOURNAL OF PHARMACOLOGY

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

(2011) Vincent Jaquet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Control of Hepatic Nuclear Superoxide Production by Glucose 6-Phosphate Dehydrogenase and NADPH Oxidase-4

(2011) Netanya Y. Spencer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   ACS Chemical Biology

The NADPH Oxidase Subunit p22phox Inhibits the Function of the Tumor Suppressor Protein Tuberin

(2010) Karen Block et al.   AMERICAN JOURNAL OF PATHOLOGY

PPARγ regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-κB

(2010) Xianghuai Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NOX2 is the primary source of angiotensin II-induced superoxide in the macula densa

(2010) Yiling Fu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

NOX2 Complex–Derived ROS as Immune Regulators

(2010) Outi Sareila et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species derived from Nox4 mediateBMP2gene transcription and osteoblast differentiation

(2010) Chandi C. Mandal et al.   BIOCHEMICAL JOURNAL

Constitutive NADPH-Dependent Electron Transferase Activity of the Nox4 Dehydrogenase Domain

(2010) Yukio Nisimoto et al.   BIOCHEMISTRY

New insight into the Nox4 subcellular localization in HEK293 cells: First monoclonal antibodies against Nox4

(2010) Leilei Zhang et al.   BIOCHIMIE

Extracellular hydrogen peroxide contributes to oxidative glutamate toxicity

(2010) Jong Seong Ha et al.   BRAIN RESEARCH

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury

(2010) S Ben Mkaddem et al.   CELL DEATH AND DIFFERENTIATION

Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells

(2010) Augusto C. Montezano et al.   CIRCULATION RESEARCH

Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein–Induced Macrophage Death

(2010) Chi Fung Lee et al.   CIRCULATION RESEARCH

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Nox4-dependent H2O2 production contributes to chronic glutamate toxicity in primary cortical neurons

(2010) Jong Seong Ha et al.   EXPERIMENTAL CELL RESEARCH

NADPH oxidase 4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction

(2010) Jie Zhuang et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH oxidase 4 mediates TGF-β-induced smooth muscle α-actin via p38MAPK and serum response factor

(2010) Abel Martin-Garrido et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection

(2010) Nabora Soledad Reyes de Mochel et al.   HEPATOLOGY

Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition

(2010) Sven Wind et al.   HYPERTENSION

Oxidative Modification of Nuclear Mitogen-activated Protein Kinase Phosphatase 1 Is Involved in Transforming Growth Factor β1-induced Expression of Plasminogen Activator Inhibitor 1 in Fibroblasts

(2010) Rui-Ming Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pro-Inflammatory Effects of Interleukin-17A on Vascular Smooth Muscle Cells Involve NAD(P)H- Oxidase Derived Reactive Oxygen Species

(2010) Eweline Pietrowski et al.   JOURNAL OF VASCULAR RESEARCH

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

Residual NADPH Oxidase and Survival in Chronic Granulomatous Disease

(2010) Douglas B. Kuhns et al.   NEW ENGLAND JOURNAL OF MEDICINE

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The many roles of NOX2 NADPH oxidase-derived ROS in immunity

(2010) Grace Y. Lam et al.   Seminars in Immunopathology

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-α in cerebral vascular endothelial cells

(2009) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Translation-Linked mRNA Destabilization Accompanying Serum-Induced Nox4 Expression in Human Endothelial Cells

(2009) Hitesh Peshavariya et al.   ANTIOXIDANTS & REDOX SIGNALING

Long-Term Cyclic Strain Downregulates Endothelial Nox4

(2009) Claudia Goettsch et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hypoxia-Inducible Factor-2α Is Stabilized by Oxidative Stress Involving NOX4

(2009) Isabel Diebold et al.   ANTIOXIDANTS & REDOX SIGNALING

Decision Analysis Supports the Paradigm That Indiscriminate Supplementation of Vitamin E Does More Harm than Good

(2009) Yedidya Dotan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanisms of Vascular Smooth Muscle NADPH Oxidase 1 (Nox1) Contribution to Injury-Induced Neointimal Formation

(2009) Moo Yeol Lee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH Oxidases: Functions and Pathologies in the Vasculature

(2009) Bernard Lassègue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nox4 overexpression activates reactive oxygen species and p38 MAPK in human endothelial cells

(2009) Claudia Goettsch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of human vascular NADPH oxidase by apocynin derived oligophenols

(2009) Mauricio Mora-Pale et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca2+ pump

(2009) T Tazzeo et al.   BRITISH JOURNAL OF PHARMACOLOGY

NADPH Oxidase 4 Contributes to Transformation Phenotype of Melanoma Cells by Regulating G2-M Cell Cycle Progression

(2009) M. Yamaura et al.   CANCER RESEARCH

NADPH Oxidase-derived ROS Contributes to Upregulation of TRPC6 Expression in Puromycin Aminonucleoside-induced Podocyte Injury

(2009) Ziying Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues

(2009) Urbain Weyemi et al.   ENDOCRINE-RELATED CANCER

A role for NADPH oxidase 4 in the activation of vascular endothelial cells by oxidized phospholipids

(2009) Sangderk Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH oxidases are responsible for the failure of nitric oxide to inhibit migration of smooth muscle cells exposed to high glucose

(2009) XiaoYong Tong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

D 1 -Like Receptors Regulate NADPH Oxidase Activity and Subunit Expression in Lipid Raft Microdomains of Renal Proximal Tubule Cells

(2009) Hewang Li et al.   HYPERTENSION

Genetic Silencing of Nox2 and Nox4 Reveals Differential Roles of These NADPH Oxidase Homologues in the Vasopressor and Dipsogenic Effects of Brain Angiotensin II

(2009) Jeffrey R. Peterson et al.   HYPERTENSION

Early lipopolysaccharide-induced reactive oxygen species production evokes necrotic cell death in human umbilical vein endothelial cells

(2009) Felipe Simon et al.   JOURNAL OF HYPERTENSION

NOX4 Expression in Human Microglia Leads to Constitutive Generation of Reactive Oxygen Species and to Constitutive IL-6 Expression

(2009) Bin Li et al.   Journal of Innate Immunity

Stress-induced activation of Nox contributes to cell survival signalling via production of hydrogen peroxide

(2009) Gillian Groeger et al.   JOURNAL OF NEUROCHEMISTRY

NADPH Oxidase Is Required for the Sensory Plasticity of the Carotid Body by Chronic Intermittent Hypoxia

(2009) Y.- J. Peng et al.   JOURNAL OF NEUROSCIENCE

NAD(P)H Oxidase Mediates TGF- 1-Induced Activation of Kidney Myofibroblasts

(2009) C. D. Bondi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway

(2009) R Naughton et al.   LEUKEMIA

Structural Insights into Nox4 and Nox2: Motifs Involved in Function and Cellular Localization

(2009) K. von Lohneysen et al.   MOLECULAR AND CELLULAR BIOLOGY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel p47phox-Related Organizers Regulate Localized NADPH Oxidase 1 (Nox1) Activity

(2009) D. Gianni et al.   Science Signaling

Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

(2009) B. Diaz et al.   Science Signaling

Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells

(2009) Amandine Jaulmes et al.   THROMBOSIS RESEARCH

Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2

(2008) Qingzhong Xiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NOX4 Regulates ROS Levels Under Normoxic and Hypoxic Conditions, Triggers Proliferation, and Inhibits Apoptosis in Pulmonary Artery Adventitial Fibroblasts

(2008) Shu Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of Structural Elements in Nox1 and Nox4 Controlling Localization and Activity

(2008) Ina Helmcke et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

(2008) Srikanth Pendyala et al.   ANTIOXIDANTS & REDOX SIGNALING

Nox4 and Nox2 NADPH Oxidases Mediate Distinct Cellular Redox Signaling Responses to Agonist Stimulation

(2008) Narayana Anilkumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes

(2008) Katrin Schröder et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-β-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms

(2008) Patricia Sancho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells

(2008) D. Meng et al.   CARDIOVASCULAR RESEARCH

Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition

(2008) T. Schluter et al.   CARDIOVASCULAR RESEARCH

Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific

(2008) Elisabetta Aldieri et al.   CURRENT DRUG METABOLISM

The Role of the Methoxyphenol Apocynin, a Vascular NADPH Oxidase Inhibitor, as a Chemopreventative Agent in the Potential Treatment of Cardiovascular Diseases

(2008) Jingjing Yu et al.   Current Vascular Pharmacology

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species

(2008) Hideki Sumimoto   FEBS Journal

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

(2008) S DIKALOV et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential roles of PKCα and PKCɛ in controlling the gene expression of Nox4 in human endothelial cells

(2008) Hui Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Expression of NADPH oxidases and enhanced H2O2-generating activity in human coronary artery endothelial cells upon induction with tumor necrosis factor-α

(2008) Lucia S. Yoshida et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival

(2008) Tadahisa Shono et al.   INTERNATIONAL JOURNAL OF CANCER

Nox4 NAD(P)H Oxidase Mediates Src-dependent Tyrosine Phosphorylation of PDK-1 in Response to Angiotensin II

(2008) Karen Block et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational Analysis Reveals Distinct Features of the Nox4-p22phoxComplex

(2008) Katharina von Löhneysen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Green tea (Camellia sinensis) Attenuates Nephropathy by Downregulating Nox4 NADPH Oxidase in Diabetic Spontaneously Hypertensive Rats

(2008) Pérola D. B. Ribaldo et al.   JOURNAL OF NUTRITION

Dystrophin-deficient cardiomyopathy in mouse: Expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart

(2008) Christopher F. Spurney et al.   NEUROMUSCULAR DISORDERS

Local production of O2− by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation

(2007) Fan Zhang et al.   CELLULAR SIGNALLING

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION