Ferroptosis and Its Role in Diverse Brain Diseases

The role of Ca 2+ in cell death caused by oxidative glutamate toxicity and ferroptosis

(2018) Pamela Maher et al.   CELL CALCIUM

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

(2018) Meiying Luo et al.   CELL DEATH AND DIFFERENTIATION

Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age-related neurodegenerative diseases

(2018) Pamela Maher   FREE RADICAL BIOLOGY AND MEDICINE

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma

(2018) Yuko Kinowaki et al.   LABORATORY INVESTIGATION

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

(2018) Moataz Abdalkader et al.   Frontiers in Neuroscience

Ultrastructural Characteristics of Neuronal Death and White Matter Injury in Mouse Brain Tissues After Intracerebral Hemorrhage: Coexistence of Ferroptosis, Autophagy, and Necrosis

(2018) Qian Li et al.   Frontiers in Neurology

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage

(2018) Zhuwei Zhang et al.   BRAIN RESEARCH

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis

(2018) Tetsuro Ishii et al.   FREE RADICAL BIOLOGY AND MEDICINE

miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma

(2018) Kexin Zhang et al.   MOLECULAR CARCINOGENESIS

Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells

(2018) Chuanhong Wu et al.   Scientific Reports

Ferroptosis: bug or feature?

(2017) Scott J. Dixon   IMMUNOLOGICAL REVIEWS

Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice

(2017) Qian Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ferrosenescence: The iron age of neurodegeneration?

(2017) Adonis Sfera et al.   MECHANISMS OF AGEING AND DEVELOPMENT

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

(2017) Delin Chen et al.   MOLECULAR CELL

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

(2017) D Chen et al.   ONCOGENE

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

(2017) Shumei Ma et al.   PLoS One

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas

(2017) Daishi Chen et al.   Oncotarget

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

(2016) Rachel P. Abrams et al.   ACS Chemical Biology

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

(2016) Yangchun Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model

(2016) Matthew Jennis et al.   GENES & DEVELOPMENT

Ferrous Iron Induces Nrf2 Expression in Mouse Brain Astrocytes to Prevent Neurotoxicity

(2016) Zhenwen Cui et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The protective effect of human platelet lysate in models of neurodegenerative disease: involvement of the Akt and MEK pathways

(2016) Flore Gouel et al.   Journal of Tissue Engineering and Regenerative Medicine

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes

(2016) Inês G. Mollet et al.   PLoS One

Tightening the connection between transposable element mobilization and aging

(2016) William C. Orr   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

(2016) Tina Sehm et al.   Oncotarget

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

(2016) Tina Sehm et al.   Oncotarget

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis

(2016) Yue-Qi Wang et al.   Frontiers in Aging Neuroscience

N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data

(2016) Daniel A. Monti et al.   PLoS One

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

(2015) Yang Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

(2015) Marie-Helene Larraufie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effects of Iron Ions and Iron Chelation on the Efficiency of Experimental Radiotherapy of Animals with Gliomas

(2015) S. D. Ivanov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

The mechanism of ageing: primary role of transposable elements in genome disintegration

(2015) Ádám Sturm et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ultrastructural Changes of Brain Tissues Surrounding Hematomas after Intracerebral Hemorrhage

(2015) Kai-Yu Wang et al.   EUROPEAN NEUROLOGY

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of  -Amyloid Precursor Protein

(2015) S. Ayton et al.   JOURNAL OF NEUROSCIENCE

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

(2015) Peng Lei et al.   NEUROBIOLOGY OF DISEASE

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function

(2015) LIANGYU CHEN et al.   ONCOLOGY REPORTS

Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

(2015) Edna Ooko et al.   PHYTOMEDICINE

The Neuroprotective Role of Ferrostatin-1 Under Rotenone-Induced Oxidative Stress in Dopaminergic Neuroblastoma Cells

(2015) Parijat Kabiraj et al.   PROTEIN JOURNAL

Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward

(2015) Ruth A. Roberts et al.   TOXICOLOGICAL SCIENCES

Iron entry in neurons and astrocytes: a link with synaptic activity

(2015) Franca Codazzi et al.   Frontiers in Molecular Neuroscience

Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress

(2015) Eric Habib et al.   Redox Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition

(2014) P. Ye et al.   MOLECULAR AND CELLULAR BIOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

PKC in developmental hypothyroid rat brain

(2014) Hong-Mei Zhang et al.   NEUROLOGICAL SCIENCES

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity

(2014) Yunyi Kang et al.   Nature Communications

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

(2014) Che-Feng Chang et al.   Annals of Clinical and Translational Neurology

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Trace Element, Antioxidant Activity, and Lipid Peroxidation Levels in Brain Cortex of Gerbils After Cerebral Ischemic Injury

(2013) Kwang-Ming Fang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke

(2013) Rachel E. Speer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pooled analysis of iron-related genes in Parkinson's disease: Association with transferrin

(2013) Shannon L. Rhodes et al.   NEUROBIOLOGY OF DISEASE

Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

(2013) Jianfang Chen et al.   PLoS One

Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study

(2013) Irene Pichler et al.   PLOS MEDICINE

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Brain iron accumulation in aging and neurodegenerative disorders

(2012) Jesper Hagemeier et al.   Expert Review of Neurotherapeutics

Lipid peroxidation triggers neurodegeneration: A redox proteomics view into the Alzheimer disease brain

(2012) Rukhsana Sultana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired Iron Status in Aging Research

(2012) Jinze Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

(2012) William M. Johnson et al.   Nutrients

Reprint of “The developing oligodendrocyte: key cellular target in brain injury in the premature infant”

(2011) Joseph J. Volpe et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Inflammation in the early stages of neurodegenerative pathology

(2011) Preeti J. Khandelwal et al.   JOURNAL OF NEUROIMMUNOLOGY

Peripheral markers in neurodegenerative patients and their first-degree relatives

(2011) Diana Olga Cristalli et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Efficacy of the lipid-soluble iron chelator 2,2′-dipyridyl against hemorrhagic brain injury

(2011) He Wu et al.   NEUROBIOLOGY OF DISEASE

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

(2011) Hui Ding et al.   PLoS One

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

(2011) A. T. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice

(2010) Junghee Lee et al.   ACTA NEUROPATHOLOGICA

Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat

(2010) Ui Jin Park et al.   ACTA NEUROPATHOLOGICA

Genetic Polymorphisms in Apolipoprotein E and Glutathione Peroxidase 1 Genes in the Ecuadorian Population Affected With Alzheimer’s Disease

(2010) César Paz-y-Miño et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Management of aplastic anemia

(2010) Catherine Nissen et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Does oxidative stress contribute to the pathology of Friedreich’s ataxia? A radical question

(2010) Jeffrey S. Armstrong et al.   FASEB JOURNAL

The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease

(2010) Youngnam N. Jin et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Iron Toxicity in Mice with Collagenase-Induced Intracerebral Hemorrhage

(2010) He Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

(2009) Y. Eberhard et al.   BLOOD

The complexity of neurobiological processes in acute ischemic stroke

(2009) R. Brouns et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-κB

(2009) W. Joon Chung et al.   JOURNAL OF NEUROCHEMISTRY

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

(2009) L. R. Hanson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Deleterious Role of Superoxide Dismutase in the Mitochondrial Intermembrane Space

(2008) Gundars Goldsteins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative and Inflammatory Pathways in Parkinson’s Disease

(2008) Rebecca L. Miller et al.   NEUROCHEMICAL RESEARCH

Oxidant–antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease

(2008) G. Nagesh Babu et al.   NEUROCHEMISTRY INTERNATIONAL