Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats

Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy

(2019) Zhi-Dong Ge et al.   International Heart Journal

Protection against diabetic cardiomyopathy is achieved using a combination of sulforaphane and zinc in type 1 diabetic OVE26 mice

(2019) Jiqun Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis

(2018) Ramoji Kosuru et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Protection by dimethyl fumarate against diabetic cardiomyopathy in type 1 diabetic mice likely via activation of nuclear factor erythroid-2 related factor 2

(2018) Xinyue Hu et al.   TOXICOLOGY LETTERS

Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry

(2018) Jasper Tromp et al.   PLOS MEDICINE

N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy

(2017) Sheng Wang et al.   MEDIATORS OF INFLAMMATION

Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?

(2016) Maximilian Hölscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy

(2015) Zoltán V. Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Redox signaling: Potential arbitrator of autophagy and apoptosis in therapeutic response

(2015) Lu Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1

(2015) Haobo Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

How Effective Are Antioxidant Supplements in Obesity and Diabetes?

(2015) Daniyal Abdali et al.   MEDICAL PRINCIPLES AND PRACTICE

Propofol Ameliorates Hyperglycemia-Induced Cardiac Hypertrophy and Dysfunction via Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Signaling Pathway in Rats*

(2014) Jinjin Xu et al.   CRITICAL CARE MEDICINE

Left atrial dysfunction in type 2 diabetes mellitus: insights from cardiac MRI

(2014) Bruno Graça et al.   EUROPEAN RADIOLOGY

Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways

(2014) Karina Huynh et al.   PHARMACOLOGY & THERAPEUTICS

Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage

(2014) Quan Liu et al.   Journal of Diabetes Investigation

Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status

(2014) Jing Chen et al.   Diabetes & Metabolism Journal

Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats

(2013) Haobo Li et al.   Cardiovascular Diabetology

Hyperglycemia-Induced Protein Kinase C  2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling

(2013) S. Lei et al.   DIABETES

Allopurinol Reduces Left Ventricular Mass in Patients With Type 2 Diabetes and Left Ventricular Hypertrophy

(2013) Benjamin R. Szwejkowski et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats

(2013) Xiaowen Mao et al.   PLoS One

Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes

(2012) Sanda Despa et al.   CIRCULATION RESEARCH

Allopurinol attenuates left ventricular dysfunction in rats with early stages of streptozotocin-induced diabetes

(2012) Xia Gao et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Diabetic cardiomyopathy: pathophysiology and clinical features

(2012) Takayuki Miki et al.   HEART FAILURE REVIEWS

Allopurinol Ameliorates Thioacetamide-Induced Acute Liver Failure by Regulating Cellular Redox-Sensitive Transcription Factors in Rats

(2012) Ulvi Demirel et al.   INFLAMMATION

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

(2011) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfuntion in rats with streptozotocin-induced diabetes

(2011) Yanan Liu et al.   CLINICAL SCIENCE

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy

(2009) Mohanraj Rajesh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH