Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pyrimethamine Elicits Antitumor Effects on Prostate Cancer by Inhibiting the p38-NF-κB Pathway

(2020) Xumin Zhou et al.   Frontiers in Pharmacology

The anthelmintic drug flubendazole induces cell apoptosis and inhibits NF-κB signaling in esophageal squamous cell carcinoma

(2019) Jiali Tao et al.   OncoTargets and Therapy

Combined bazedoxifene and paclitaxel treatments inhibit cell viability, cell migration, colony formation, and tumor growth and induce apoptosis in breast cancer

(2019) Shengling Fu et al.   CANCER LETTERS

Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy

(2019) Shichong Lin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Ferroptosis is a lysosomal cell death process

(2018) Huan Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Flubendazole overcomes trastuzumab resistance by targeting cancer stem-like properties and HER2 signaling in HER2-positive breast cancer

(2018) Yoon-Jae Kim et al.   CANCER LETTERS

Flubendazole elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition

(2018) Eunhye Oh et al.   INTERNATIONAL JOURNAL OF CANCER

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

(2018) Haider H. Dar et al.   JOURNAL OF CLINICAL INVESTIGATION

The Effect of Flubendazole on Adhesion and Migration in SW480 and SW620 Colon Cancer Cells

(2017) Veronika Hanušová et al.   Anti-Cancer Agents in Medicinal Chemistry

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Flubendazole induces mitotic catastrophe and senescence in colon cancer cellsin vitro

(2016) Věra Králová et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses

(2015) Le Jiang et al.   CELL CYCLE

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen

(2015) Martin Michaelis et al.   Scientific Reports

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

A pharmacology-based comparison of the activity of albendazole and flubendazole against Echinococcus granulosus metacestode in sheep

(2013) L. Ceballos et al.   ACTA TROPICA

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

To be, or not to be

(2013) Shang-Jui Wang et al.   CURRENT OPINION IN ONCOLOGY

The regulation of cellular metabolism by tumor suppressor p53

(2013) Yingjian Liang et al.   Cell and Bioscience

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

(2012) Sören Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Comparative Performances of Flubendazole and Albendazole in Cystic Echinococcosis:Ex VivoActivity, Plasma/Cyst Disposition, and Efficacy in Infected Mice

(2011) Laura Ceballos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs

(2011) Charles D Mackenzie et al.   Expert Review of Anti-Infective Therapy

Deconstructing p53 transcriptional networks in tumor suppression

(2011) Kathryn T. Bieging et al.   TRENDS IN CELL BIOLOGY

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

(2010) P. A. Spagnuolo et al.   BLOOD

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flubendazole in cystic echinococcosis therapy: Pharmaco-parasitological evaluation in mice

(2009) Laura Ceballos et al.   PARASITOLOGY INTERNATIONAL

Androgen deprivation therapy for prostate cancer

(2008) Eric A Singer et al.   EXPERT OPINION ON PHARMACOTHERAPY