Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

(2020) Peng Zhao et al.   SCIENCE

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

(2020) Sangwon Byun et al.   Nature Communications

Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis

(2020) Weijian Mai et al.   Frontiers in Pharmacology

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

(2020) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Protective Properties of FOXO1 Inhibition in a Murine Model of Non-alcoholic Fatty Liver Disease Are Associated With Attenuation of ER Stress and Necroptosis

(2020) Hao-ran Ding et al.   Frontiers in Physiology

Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals

(2020) Jia-Fei Poon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Redefining fatty liver disease: an international patient perspective

(2020) Gamal Shiha et al.   Lancet Gastroenterology & Hepatology

The Latin American Association for the Study of the Liver (ALEH) position statement on the redefinition of fatty liver disease

(2020) Nahum Mendez-Sanchez et al.   Lancet Gastroenterology & Hepatology

Nomenclature and definition of metabolic-associated fatty liver disease: a consensus from the Middle East and north Africa

(2020) Gamal Shiha et al.   Lancet Gastroenterology & Hepatology

The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation

(2019) Haixia Xu et al.   Molecular Metabolism

Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function

(2019) Geum-Hwa Lee et al.   Nutrients

PPARδ attenuates hepatic steatosis through autophagy-mediated fatty acid oxidation

(2019) Lei Tong et al.   Cell Death & Disease

NLRC4 inflammasome activation regulated by TNF-α promotes inflammatory responses in nonalcoholic fatty liver disease

(2019) Yihe Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Inhibition of mixed lineage kinase domain like pseudokinase decreases fat de novo synthesis and chemokine ligand expression in non‐alcoholic fatty liver disease

(2019) Waqar Khalid Saeed et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Irbesartan Ameliorates Lipid Deposition by Enhancing Autophagy via PKC/AMPK/ULK1 Axis in Free Fatty Acid Induced Hepatocytes

(2019) Juan He et al.   Frontiers in Physiology

Exogenous Administration of Low-Dose Lipopolysaccharide Potentiates Liver Fibrosis in a Choline-Deficient l-Amino-Acid-Defined Diet-Induced Murine Steatohepatitis Model

(2019) Keisuke Nakanishi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy

(2019) Yan Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Autophagy regulates lipid metabolism through selective turnover of NCoR1

(2019) Tetsuya Saito et al.   Nature Communications

Catalpol induces autophagy and attenuates liver steatosis in ob/ob and high-fat diet-induced obese mice

(2019) Huihui Ren et al.   Aging-US

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease

(2019) Amine Majdi et al.   JOURNAL OF HEPATOLOGY

Autophagosome Biogenesis Machinery

(2019) Simon A. Walker et al.   JOURNAL OF MOLECULAR BIOLOGY

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

At a glance: A history of autophagy and cancer

(2019) Xin Wen et al.   SEMINARS IN CANCER BIOLOGY

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

(2019) Eunhee Park et al.   Cell Death & Disease

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

(2019) Jing Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Osteopontin acts as a negative regulator of autophagy accelerating lipid accumulation during the development of nonalcoholic fatty liver disease

(2019) Min Tang et al.   Artificial Cells Nanomedicine and Biotechnology

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Chlorogenic acid alleviates autophagy and insulin resistance by suppressing JNK pathway in a rat model of nonalcoholic fatty liver disease

(2018) Hua Yan et al.   JOURNAL OF BIOSCIENCES

Deletion of Smad4 reduces hepatic inflammation and fibrogenesis during nonalcoholic steatohepatitis progression

(2018) Geng Qin et al.   Journal of Digestive Diseases

Pyroptosis: An inflammatory link between NAFLD and NASH with potential therapeutic implications

(2018) Juliane I. Beier et al.   JOURNAL OF HEPATOLOGY

Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury

(2018) Yi-Yuan Zheng et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy is involved in acetylshikonin ameliorating non-alcoholic steatohepatitis through AMPK/mTOR pathway

(2018) Jiacheng Zeng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice

(2018) Hong Zhong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Apoptosis and necroptosis in the liver: a matter of life and death

(2018) Robert F. Schwabe et al.   Nature Reviews Gastroenterology & Hepatology

Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway

(2018) Tianming Qiu et al.   Cell Death & Disease

Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase 3/7 activation in subjects with non-alcoholic fatty liver disease

(2018) Mitchell Shiffman et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism

(2018) Dandan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tissue-Specific Profiling of Oxidative Stress-Associated Transcriptome in a Healthy Mouse Model

(2018) Jung Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress

(2018) Jhee Hong Koh et al.   JOURNAL OF CELL SCIENCE

Nonalcoholic Fatty Liver Disease

(2018) Irene Pierantonelli et al.   TRANSPLANTATION

Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease

(2018) Waqar Khalid Saeed et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Herbal Extracts and Natural Products in Alleviating Non-alcoholic Fatty Liver Disease via Activating Autophagy

(2018) Li Zhang et al.   Frontiers in Pharmacology

Deficiency of CKIP-1 aggravates high-fat diet-induced fatty liver in mice

(2017) Yutao Zhan et al.   EXPERIMENTAL CELL RESEARCH

Current and future pharmacological therapies for NAFLD/NASH

(2017) Yoshio Sumida et al.   JOURNAL OF GASTROENTEROLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Cytokeratin-18 and uric acid predicts disease severity in Taiwanese nonalcoholic steatohepatitis patients

(2017) Jee-Fu Huang et al.   PLoS One

Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease

(2017) Cong Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice

(2017) Pedro M Rodrigues et al.   Cell Death & Disease

Randomized Phase II Study of the X-linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)

(2016) Francis A.S. Lee et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents

(2016) Spandana Rajendra Kopalli et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Cell death-independent activities of the death receptors CD95, TRAILR1, and TRAILR2

(2016) Daniela Siegmund et al.   FEBS Journal

Regulation of Liver Metabolism by Autophagy

(2016) Julio Madrigal-Matute et al.   GASTROENTEROLOGY

Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury

(2016) Sanjoy Roychowdhury et al.   HEPATOLOGY

Histological severity and clinical outcomes of nonalcoholic fatty liver disease in nonobese patients

(2016) Jonathan Chung-Fai Leung et al.   HEPATOLOGY

Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors

(2016) Yuko Akazawa et al.   HEPATOLOGY RESEARCH

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

(2016) Imanol Zubiete-Franco et al.   JOURNAL OF HEPATOLOGY

CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy

(2016) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB

(2016) Jo Suda et al.   JOURNAL OF IMMUNOLOGY

Plasma Cytokeratin-18 Level As a Novel Biomarker for Liver Fibrosis in Children With Nonalcoholic Fatty Liver Disease

(2016) Chetan Mandelia et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Intracellular and extracellular miRNome deregulation in cellular models of NAFLD or NASH: Clinical implications

(2016) S. Di Mauro et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Iron and non-alcoholic fatty liver disease

(2016) Laurence J Britton et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation

(2016) Ayano Takagi et al.   Scientific Reports

SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy

(2016) Kwang-Youn Kim et al.   Scientific Reports

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

(2016) Bradley A. Carlson et al.   Redox Biology

The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

(2016) Rosa S. Kim et al.   Scientific Reports

Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stress

(2015) J. D. Mosinski et al.   Acta Physiologica

Hypoxia Activation of Mitophagy and Its Role in Disease Pathogenesis

(2015) Hao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease

(2015) Rui Guo et al.   Hepatobiliary & Pancreatic Diseases International

Glucose fluctuation increased hepatocyte apoptosis under lipotoxicity and the involvement of mitochondrial permeability transition opening

(2015) Xueyao Yin et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Evaluation of circulating markers of hepatic apoptosis and inflammation in obese children with and without obstructive sleep apnea

(2015) Naim Alkhouri et al.   SLEEP MEDICINE

Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease

(2015) W Shan et al.   Cell Death & Disease

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

Cyanidin-3-O-β-glucoside protects primary mouse hepatocytes against high glucose-induced apoptosis by modulating mitochondrial dysfunction and the PI3K/Akt pathway

(2014) Xinwei Jiang et al.   BIOCHEMICAL PHARMACOLOGY

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis

(2014) S Orozco et al.   CELL DEATH AND DIFFERENTIATION

The Fatty Acid–Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease

(2014) Rifaat Safadi et al.   Clinical Gastroenterology and Hepatology

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

(2014) M V Machado et al.   GUT

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

(2014) Sayaka Inokuchi-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice

(2014) Daniela C. Kroy et al.   JOURNAL OF HEPATOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Mmu-miR-615-3p Regulates Lipoapoptosis by Inhibiting C/EBP Homologous Protein

(2014) Yasuhiro Miyamoto et al.   PLoS One

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

(2014) Robert A. Egnatchik et al.   Molecular Metabolism

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis

(2013) Yoon Seok Roh et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease

(2013) Kenneth Cusi et al.   JOURNAL OF HEPATOLOGY

TLR-induced PAI-2 expression suppresses IL-1  processing via increasing autophagy and NLRP3 degradation

(2013) S.-Y. Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation

(2013) Mihael Vucur et al.   Cell Reports

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

A hedgehog survival pathway in ‘undead’ lipotoxic hepatocytes

(2012) Keisuke Kakisaka et al.   JOURNAL OF HEPATOLOGY

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

(2012) Rui E. Castro et al.   JOURNAL OF HEPATOLOGY

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transsulfuration pathway: a source of cysteine for glutathione in astrocytes

(2011) Gethin J. McBean   AMINO ACIDS

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

(2011) Junji Ezaki et al.   Autophagy

Hepcidin: A novel peptide hormone regulating iron metabolism

(2011) Bhawna Singh et al.   CLINICA CHIMICA ACTA

Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease

(2011) D. M. S. Ferreira et al.   DIABETOLOGIA

Intestinal DMT1 Cotransporter Is Down-regulated by Hepcidin via Proteasome Internalization and Degradation

(2011) Carole Brasse–Lagnel et al.   GASTROENTEROLOGY

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis

(2011) Vlad Ratziu et al.   HEPATOLOGY

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA

(2011) Sophie C. Cazanave et al.   JOURNAL OF LIPID RESEARCH

Serum Levels of Hepcidin in Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease

(2011) Ebubekir Senates et al.   Metabolic Syndrome and Related Disorders

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications

(2011) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis

(2010) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease

(2010) Anna Alisi et al.   LABORATORY INVESTIGATION

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Apoptosis and Cytokines in Non-Alcoholic Steatohepatitis

(2009) Wing-Kin Syn et al.   Clinics in Liver Disease

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

(2009) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

(2008) N. Raben et al.   HUMAN MOLECULAR GENETICS

Iron in NASH, chronic liver diseases and HCC: How much iron is too much?

(2008) Antonello Pietrangelo   JOURNAL OF HEPATOLOGY

A Novel Diagnostic Biomarker Panel for Obesity-related Nonalcoholic Steatohepatitis (NASH)

(2008) Zobair M. Younossi et al.   OBESITY SURGERY