Ferroptosis and Its Modulation by Autophagy in Light of the Pathogenesis of Lysosomal Storage Diseases

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hyperferritinemia and diagnosis of type 1 Gaucher disease

(2020) Giacomo Marchi et al.   AMERICAN JOURNAL OF HEMATOLOGY

Iron chelation by deferiprone does not rescue the Niemann-Pick Disease Type C1 mouse model

(2020) Ya Hui Hung et al.   BIOMETALS

Expression of genes involved in apoptosis is dysregulated in mucopolysaccharidoses as revealed by pilot transcriptomic analyses

(2020) Joanna Brokowska et al.   CELL BIOLOGY INTERNATIONAL

Genetic Base of Behavioral Disorders in Mucopolysaccharidoses: Transcriptomic Studies

(2020) Karolina Pierzynowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Underestimated Aspect of Mucopolysaccharidosis Pathogenesis: Global Changes in Cellular Processes Revealed by Transcriptomic Studies

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Ferroptotic agent‐induced endoplasmic reticulum stress response plays a pivotal role in the autophagic process outcome

(2020) Young‐Sun Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue

(2020) Riccardo Turchi et al.   Cell Death & Disease

Identification of Frataxin as a regulator of ferroptosis

(2020) Jing Du et al.   Redox Biology

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transcriptomic Changes Related to Cellular Processes with Particular Emphasis on Cell Activation in Lysosomal Storage Diseases from the Group of Mucopolysaccharidoses

(2020) Estera Rintz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroptosis and Its Potential Role in Human Diseases

(2020) Chu Han et al.   Frontiers in Pharmacology

Lysosomal storage diseases: current therapies and future alternatives

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Erastin triggers autophagic death of breast cancer cells by increasing intracellular iron levels

(2020) Mengxin Li et al.   Oncology Letters

Treatment for Lysosomal Storage Disorders

(2020) Jayesh Sheth et al.   CURRENT PHARMACEUTICAL DESIGN

Fibrillar α-synuclein toxicity depends on functional lysosomes

(2020) Stephanie J Guiney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in expressions of genes involved in the regulation of cellular processes in mucopolysaccharidoses as assessed by fibroblast culture-based transcriptomic analyses

(2020) Lidia Gaffke et al.   METABOLIC BRAIN DISEASE

Proteasome Composition and Activity Changes in Cultured Fibroblasts Derived From Mucopolysaccharidoses Patients and Their Modulation by Genistein

(2020) Karolina Pierzynowska et al.   Frontiers in Cell and Developmental Biology

Pompe Disease: New Developments in an Old Lysosomal Storage Disorder

(2020) Naresh K. Meena et al.   Biomolecules

Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis

(2020) Jingjing Liu et al.   TOXICOLOGY

The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia

(2020) Piergiorgio La Rosa et al.   Redox Biology

Ferroptosis as a novel therapeutic target for Friedreich's ataxia

(2019) M. Grazia Cotticelli et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

(2019) Rainer Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The release and activity of HMGB1 in ferroptosis

(2019) Qirong Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Maladie de Gaucher de type 1 simulant une thrombopénie immunologique : intérêt de l’hyperferritinémie et de l’hypergammaglobulinémie dans le bilan d’une thrombopénie isolée

(2019) B. Faucher et al.   REVUE DE MEDECINE INTERNE

Standard-flow LC and thermal focusing ESI elucidates altered liver proteins in late stage Niemann–Pick, type C1 disease

(2019) Melissa R Pergande et al.   Bioanalysis

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury

(2019) Lianjiu Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

(2019) Lian-Jiu Su et al.   Oxidative Medicine and Cellular Longevity

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

(2019) Tae-Jun Park et al.   Cell Death & Disease

Changes in cellular processes occurring in mucopolysaccharidoses as underestimated pathomechanisms of these diseases

(2019) Lidia Gaffke et al.   CELL BIOLOGY INTERNATIONAL

Ferritinemia and serum inflammatory cytokines in Swedish adults with Gaucher disease type 1

(2018) Fryderyk Lorenz et al.   BLOOD CELLS MOLECULES AND DISEASES

Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease

(2018) Vincent Puy et al.   GLIA

Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease

(2018) Thibaud Lefebvre et al.   HAEMATOLOGICA

Hepatocellular carcinoma in Gaucher disease: an international case series

(2018) Martine Regenboog et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The p53-p21 pathway inhibits ferroptosis during metabolic stress

(2018) Amy Tarangelo et al.   Oncotarget

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease

(2018) Thibaud Lefebvre et al.   HAEMATOLOGICA

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Oxidative stress and the altered reaction to it in Fabry disease: A possible target for cardiovascular-renal remodeling?

(2018) Verdiana Ravarotto et al.   PLoS One

Lipid storage and lipophagy regulates ferroptosis

(2018) Yuansong Bai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lysosomal storage diseases

(2018) Frances M. Platt et al.   Nature Reviews Disease Primers

Targeted p53 on Small-Molecules-Induced Ferroptosis in Cancers

(2018) Weifen Zhang et al.   Frontiers in Oncology

Dysregulation of autophagy as a common mechanism in lysosomal storage diseases

(2017) Elena Seranova et al.   Essays in Biochemistry

Tetrahydrobiopterin deficiency in the pathogenesis of Fabry disease

(2017) Jin-Song Shen et al.   HUMAN MOLECULAR GENETICS

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

(2017) Delin Chen et al.   MOLECULAR CELL

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Oxidative and nitrative stress and pro-inflammatory cytokines in Mucopolysaccharidosis type II patients: effect of long-term enzyme replacement therapy and relation with glycosaminoglycan accumulation

(2016) Carlos Eduardo Diaz Jacques et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Emerging roles for lipids in non-apoptotic cell death

(2016) L Magtanong et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Biomolecules damage and redox status abnormalities in Fabry patients before and during enzyme replacement therapy

(2016) Giovana Brondani Biancini et al.   CLINICA CHIMICA ACTA

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glutathione peroxidase 4: a new player in neurodegeneration?

(2016) B R Cardoso et al.   MOLECULAR PSYCHIATRY

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Lysosomal Storage Diseases: From Pathophysiology to Therapy

(2015) Giancarlo Parenti et al.   Annual Review of Medicine

Oxidative stress and inflammation in mucopolysaccharidosis type IVA patients treated with enzyme replacement therapy

(2015) Bruna Donida et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Iron homeostasis and infIammatory biomarker analysis in patients with type 1 Gaucher disease

(2014) B. Medrano-Engay et al.   BLOOD CELLS MOLECULES AND DISEASES

Gaucher disease: Plasmalogen levels in relation to primary lipid abnormalities and oxidative stress

(2014) Marina Moraitou et al.   BLOOD CELLS MOLECULES AND DISEASES

Late diagnosis of fucosidosis in a child with progressive fixed dystonia, bilateral pallidal lesions and red spots on the skin

(2014) Matthias Gautschi et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Effect of vitamin D3 intake on the onset of disease in a murine model of human Krabbe disease

(2014) Manjeet K. Paintlia et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hepatic metabolic response to restricted copper intake in a Niemann–Pick C murine model

(2014) Graciela Argüello et al.   Metallomics

Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?

(2013) Jessica Coblentz et al.   BIOCHEMICAL JOURNAL

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

(2013) Laura D. Osellame et al.   Cell Metabolism

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Liver Fibrosis in Type I Gaucher Disease: Magnetic Resonance Imaging, Transient Elastography and Parameters of Iron Storage

(2013) Anneloes E. Bohte et al.   PLoS One

Ferritinemia during type 1 Gaucher disease: Mechanisms and progression under treatment

(2012) Arsène Mekinian et al.   BLOOD CELLS MOLECULES AND DISEASES

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The role of autophagy in the pathogenesis of glycogen storage disease type II (GSDII)

(2012) A C Nascimbeni et al.   CELL DEATH AND DIFFERENTIATION

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

p62/SQSTM1 prominently accumulates in renal proximal tubules in nephropathic cystinosis

(2012) Poonam Sansanwal et al.   PEDIATRIC NEPHROLOGY

Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells

(2011) Martijn J. Wilmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Globotriaosylceramide is correlated with oxidative stress and inflammation in Fabry patients treated with enzyme replacement therapy

(2011) Giovana B. Biancini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TRPML: Transporters of metals in lysosomes essential for cell survival?

(2011) Kirill Kiselyov et al.   CELL CALCIUM

Oxidative stress in patients with mucopolysaccharidosis type II before and during enzyme replacement therapy

(2011) Letícia Filippon et al.   MOLECULAR GENETICS AND METABOLISM

Hyperferritinemia and iron overload in type 1 Gaucher disease

(2010) Philip Stein et al.   AMERICAN JOURNAL OF HEMATOLOGY

Autophagosome maturation is impaired in Fabry disease

(2010) Marc Chévrier et al.   Autophagy

Macroautophagy is defective in mucolipin-1-deficient mouse neurons

(2010) Cyntia Curcio-Morelli et al.   NEUROBIOLOGY OF DISEASE

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucopolysaccharidosis IIIB: Oxidative damage and cytotoxic cell involvement in the neuronal pathogenesis

(2009) Guglielmo R.D. Villani et al.   BRAIN RESEARCH

Alterations in Oxidative Markers in the Cerebellum and Peripheral Organs in MPS I Mice

(2009) Gustavo Kellermann Reolon et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuropathology of the Mcoln1−/− Knockout Mouse Model of Mucolipidosis Type IV

(2009) Matthew C. Micsenyi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Inhibition of autophagosome formation restores mitochondrial function in mucolipidosis II and III skin fibroblasts

(2009) Takanobu Otomo et al.   MOLECULAR GENETICS AND METABOLISM

Critical role of iron in the pathogenesis of the murine gangliosidoses

(2009) Mylvaganam Jeyakumar et al.   NEUROBIOLOGY OF DISEASE

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone

(2008) Stefania Zampieri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Developmental impairments of select neurotransmitter systems in brains ofCln3Δex7/8 knock-in mice, an animal model of juvenile neuronal ceroid lipofuscinosis

(2008) Philipp Herrmann et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational and oxidative stress analysis in patients with mucopolysaccharidosis type I undergoing enzyme replacement therapy

(2007) Vanessa Gonçalves Pereira et al.   CLINICA CHIMICA ACTA